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D0KX99 (D0KX99_HALNC) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase HAMAP-Rule MF_00811
EC=2.3.1.117 HAMAP-Rule MF_00811
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferase HAMAP-Rule MF_00811
Gene names
Name:dapD HAMAP-Rule MF_00811
Ordered Locus Names:Hneap_0250
OrganismHalothiobacillus neapolitanus (strain ATCC 23641 / c2) (Thiobacillus neapolitanus) [Complete proteome] [HAMAP]
Taxonomic identifier555778 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Halothiobacillaceae › Halothiobacillus ›

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate. HAMAP-Rule MF_00811 SAAS SAAS023180

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3. HAMAP-Rule MF_00811 SAAS SAAS023180

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_00811

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00811 SAAS SAAS023180.

Sequence similarities

Belongs to the transferase hexapeptide repeat family. HAMAP-Rule MF_00811

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site1081Substrate By similarity HAMAP-Rule MF_00811
Binding site1451Substrate By similarity HAMAP-Rule MF_00811

Sequences

Sequence LengthMass (Da)Tools
D0KX99 [UniParc].

Last modified December 15, 2009. Version 1.
Checksum: 0F71737660302A80

FASTA27729,623
        10         20         30         40         50         60 
MTDLNALKNT IETAFEDRAS ITPAEAPQAV RDAVNTVLGM LDAGQLRVAE RRGVGDWVVN 

        70         80         90        100        110        120 
EWLKKAVLLS FRLNPNEVVQ GGDLRYFDKV PTKFANWNQA QFEEAGIRVV PNAVARRGSF 

       130        140        150        160        170        180 
IAKGAVLMPS YVNIGAYVDE GTMVDTWATV GSCAQIGKNV HLSGGVGIGG VLEPLQASPT 

       190        200        210        220        230        240 
IIEDNCFIGA RSEVVEGVIV EEGSVISMGV YIGQSTKIYD RETGEVSYGR IPAGSVVVSG 

       250        260        270 
NLPSKCGKYS LYCAVIVKKV DAKTLSKVGI NALLRDI

« Hide

References

[1]"Complete sequence of Halothiobacillus neapolitanus c2."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Davenport K., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Kerfeld C., Cannon G., Heinhort S.
Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23641 / c2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001801 Genomic DNA. Translation: ACX95113.1.
RefSeqYP_003262160.1. NC_013422.1.

3D structure databases

ProteinModelPortalD0KX99.
ModBaseSearch...

Protein-protein interaction databases

STRING555778.Hneap_0250.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACX95113; ACX95113; Hneap_0250.
GeneID8533365.
KEGGhna:Hneap_0250.
PATRIC32204284. VBIHalNea120669_0248.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2171.
HOGENOMHOG000003295.
KOK00674.
OMANQWAKKA.

Enzyme and pathway databases

BioCycHNEA555778:GIVV-252-MONOMER.
UniPathwayUPA00034; UER00019.

Family and domain databases

Gene3D1.10.166.10. 1 hit.
HAMAPMF_00811. DapD.
InterProIPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PANTHERPTHR19136:SF52. PTHR19136:SF52. 1 hit.
PfamPF00132. Hexapep. 2 hits.
[Graphical view]
SUPFAMSSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMsTIGR00965. dapD. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD0KX99_HALNC
AccessionPrimary (citable) accession number: D0KX99
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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