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D0KT28

- D0KT28_SULS9

UniProt

D0KT28 - D0KT28_SULS9

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, Ssol_1680
Organism
Sulfolobus solfataricus (strain 98/2)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarityUniRule annotation
Binding sitei30 – 301Substrate By similarityUniRule annotation
Active sitei61 – 611Proton donor By similarityUniRule annotation
Binding sitei99 – 991Sulfate 2Imported
Binding sitei115 – 1151Substrate By similarityUniRule annotation
Binding sitei121 – 1211Sulfate 3
Binding sitei148 – 1481Sulfate 3
Binding sitei169 – 1691Sulfate 4
Binding sitei187 – 1871Substrate; via amide nitrogen By similarityUniRule annotation
Binding sitei188 – 1881Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciSSOL555311:GLLY-1711-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylase
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:Ssol_1680Imported
OrganismiSulfolobus solfataricus (strain 98/2)Imported
Taxonomic identifieri555311 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001493: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DBDX-ray1.70A1-222[»]
4DBEX-ray1.79A/B1-222[»]
ProteinModelPortaliD0KT28.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 6810Substrate binding By similarityUniRule annotation
Regioni164 – 17411Substrate binding By similarityUniRule annotationAdd
BLAST
Regioni187 – 1882Sulfate 4 binding

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000226069.
KOiK01591.
OMAiTEMSHPG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_A. OMPdecase_type1_A.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

D0KT28-1 [UniParc]FASTAAdd to Basket

« Hide

MLKSRVILAM DKPLSYQVLK EMENELYGIK VGLPLVLDLG VDKTRELLIG    50
LDVEEIIVDF KLADIGYIMK SIVERLSFAN SFIAHSFIGV KGSLDELKRY 100
LDANSKNLYL VAVMSHEGWS TLFADYIKNV IREISPKGIV VGGTKLDHIT 150
QYRRDFEKMT IVSPGMGSQG GSYGDAVCAG ADYEIIGRSI YNAGNPLTAL 200
RTINKIIEDK VMKCKGAIFR KK 222
Length:222
Mass (Da):24,701
Last modified:December 15, 2009 - v1
Checksum:i48F3E83DB0F043FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001800 Genomic DNA. Translation: ACX91897.1.
RefSeqiWP_009991148.1. NZ_ACUK01000205.1.
YP_005643498.1. NC_017274.1.

Genome annotation databases

EnsemblBacteriaiACX91897; ACX91897; Ssol_1680.
GeneIDi12257711.
KEGGisol:Ssol_1680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001800 Genomic DNA. Translation: ACX91897.1 .
RefSeqi WP_009991148.1. NZ_ACUK01000205.1.
YP_005643498.1. NC_017274.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DBD X-ray 1.70 A 1-222 [» ]
4DBE X-ray 1.79 A/B 1-222 [» ]
ProteinModelPortali D0KT28.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACX91897 ; ACX91897 ; Ssol_1680 .
GeneIDi 12257711.
KEGGi sol:Ssol_1680.

Phylogenomic databases

HOGENOMi HOG000226069.
KOi K01591.
OMAi TEMSHPG.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci SSOL555311:GLLY-1711-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_A. OMPdecase_type1_A.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of Sulfolobus solfataricus 98/2."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Mead D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 98/2Imported.
  2. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus complexed with inhibitor BMP."
    Fedorov A.A., Fedorov E.V., Desai B., Gerlt J.A., Almo S.C.
    Submitted (JAN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS).
  3. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus."
    Fedorov A.A., Fedorov E.V., Desai B., Gerlt J.A., Almo S.C.
    Submitted (JAN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).

Entry informationi

Entry nameiD0KT28_SULS9
AccessioniPrimary (citable) accession number: D0KT28
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: September 3, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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