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D0KT28

- D0KT28_SULS9

UniProt

D0KT28 - D0KT28_SULS9

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Sulfolobus solfataricus (strain 98/2)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111SubstrateUniRule annotation
    Binding sitei30 – 301SubstrateUniRule annotation
    Active sitei61 – 611Proton donorUniRule annotation
    Binding sitei99 – 991Sulfate 2Imported
    Binding sitei115 – 1151SubstrateUniRule annotation
    Binding sitei121 – 1211Sulfate 3
    Binding sitei148 – 1481Sulfate 3
    Binding sitei169 – 1691Sulfate 4
    Binding sitei187 – 1871Substrate; via amide nitrogenUniRule annotation
    Binding sitei188 – 1881SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesisUniRule annotation

    Enzyme and pathway databases

    BioCyciSSOL555311:GLLY-1711-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:Ssol_1680Imported
    OrganismiSulfolobus solfataricus (strain 98/2)Imported
    Taxonomic identifieri555311 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001493: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DBDX-ray1.70A1-222[»]
    4DBEX-ray1.79A/B1-222[»]
    ProteinModelPortaliD0KT28.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni59 – 6810Substrate bindingUniRule annotation
    Regioni164 – 17411Substrate bindingUniRule annotationAdd
    BLAST
    Regioni187 – 1882Sulfate 4 binding

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000226069.
    KOiK01591.
    OMAiTEMSHPG.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_A. OMPdecase_type1_A.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D0KT28-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKSRVILAM DKPLSYQVLK EMENELYGIK VGLPLVLDLG VDKTRELLIG    50
    LDVEEIIVDF KLADIGYIMK SIVERLSFAN SFIAHSFIGV KGSLDELKRY 100
    LDANSKNLYL VAVMSHEGWS TLFADYIKNV IREISPKGIV VGGTKLDHIT 150
    QYRRDFEKMT IVSPGMGSQG GSYGDAVCAG ADYEIIGRSI YNAGNPLTAL 200
    RTINKIIEDK VMKCKGAIFR KK 222
    Length:222
    Mass (Da):24,701
    Last modified:December 15, 2009 - v1
    Checksum:i48F3E83DB0F043FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001800 Genomic DNA. Translation: ACX91897.1.
    RefSeqiWP_009991148.1. NZ_ACUK01000205.1.
    YP_005643498.1. NC_017274.1.

    Genome annotation databases

    EnsemblBacteriaiACX91897; ACX91897; Ssol_1680.
    GeneIDi12257711.
    KEGGisol:Ssol_1680.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001800 Genomic DNA. Translation: ACX91897.1 .
    RefSeqi WP_009991148.1. NZ_ACUK01000205.1.
    YP_005643498.1. NC_017274.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DBD X-ray 1.70 A 1-222 [» ]
    4DBE X-ray 1.79 A/B 1-222 [» ]
    ProteinModelPortali D0KT28.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACX91897 ; ACX91897 ; Ssol_1680 .
    GeneIDi 12257711.
    KEGGi sol:Ssol_1680.

    Phylogenomic databases

    HOGENOMi HOG000226069.
    KOi K01591.
    OMAi TEMSHPG.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci SSOL555311:GLLY-1711-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_A. OMPdecase_type1_A.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Sulfolobus solfataricus 98/2."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Mead D.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 98/2Imported.
    2. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus complexed with inhibitor BMP."
      Fedorov A.A., Fedorov E.V., Desai B., Gerlt J.A., Almo S.C.
      Submitted (JAN-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS).
    3. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus."
      Fedorov A.A., Fedorov E.V., Desai B., Gerlt J.A., Almo S.C.
      Submitted (JAN-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).

    Entry informationi

    Entry nameiD0KT28_SULS9
    AccessioniPrimary (citable) accession number: D0KT28
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 15, 2009
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3