D0KSY9 (D0KSY9_SULS9) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ketol-acid reductoisomerase HAMAP MF_00435
EC=1.1.1.86 HAMAP MF_00435

Alternative name(s):
Acetohydroxy-acid isomeroreductase HAMAP MF_00435
Alpha-keto-beta-hydroxylacil reductoisomerase HAMAP MF_00435

Gene names

Name:	ilvC HAMAP MF_00435
Ordered Locus Names:	Ssol_1641

Organism

Sulfolobus solfataricus (strain 98/2) [Complete proteome] [HAMAP]

Taxonomic identifier

555311 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435
Sequence similarities	Belongs to the ketol-acid reductoisomerase family. HAMAP MF_00435

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis HAMAP MF_00435
Ligand	NADP HAMAP MF_00435
Molecular function	Isomerase EMBL ACX91858.1 Oxidoreductase HAMAP MF_00435 EMBL ACX91858.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	111	1	By similarity HAMAP MF_00435

Sequences

	Sequence		Length	Mass (Da)
	D0KSY9 [UniParc]. Last modified December 15, 2009. Version 1. Checksum: 3246B80649CA0516	FASTA	335	36,811
	10 20 30 40 50 60 MKCTSKIYTD NDANLDLIKG KRIAVLGYGS QGRAWAQNLR DSGLNVVVGL EREGKSWELA 70 80 90 100 110 120 KSDGITPLHT KDAVKDADII IFLVPDMVQR TLWLESVQPY MKKGADLVFA HGFNIHYKLI 130 140 150 160 170 180 DPPKDSDVYM IAPKGPGPTV REYYKAGGGV PALVAVHQDV SGTALHKALA IAKGIGATRA 190 200 210 220 230 240 GVIPTTFKEE TETDLFGEQV ILVGGIMELM RAAFETLVEE GYQPEVAYFE TINELKMLVD 250 260 270 280 290 300 LVYEKGISGM LKAVSDTAKY GGMTVGKFVI DESVRKRMKE ALQRIKSGKF AEEWVEEYGR 310 320 330 GMPTVVNGLS NVQNSLEEKI GNQLRDLVQK GKPKS

References

[1]

"Complete sequence of Sulfolobus solfataricus 98/2." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Mead D. Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 98/2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001800 Genomic DNA. Translation: ACX91858.1.
3D structure databases
ProteinModelPortal	D0KSY9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GenomeReviews	Gene locus Ssol_1641 in contig CP001800_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAYAKGI.
Family and domain databases
HAMAP	MF_00435. IlvC. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013328. DH_multihelical. IPR013116. IlvN. [Graphical view]
Gene3D	G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00465. IlvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D0KSY9_SULS9

Accession

Primary (citable) accession number: D0KSY9

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2009
Last sequence update:	December 15, 2009
Last modified:	October 19, 2011
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)