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D0KQM8

- AGLU_SULS9

UniProt

D0KQM8 - AGLU_SULS9

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Protein

Alpha-glucosidase

Gene

malA

Organism
Sulfolobus solfataricus (strain 98/2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Major soluble alpha-glucosidase.1 Publication

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

pH dependencei

Optimum pH is 4.5 for maltose hydrolysis, and 5.5 for glucogen hydrolysis.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei320 – 3201By similarity
Active sitei323 – 3231By similarity
Active sitei416 – 4161Proton donorBy similarity

GO - Molecular functioni

  1. alpha-1,4-glucosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSSOL555311:GLLY-794-MONOMER.

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-glucosidase (EC:3.2.1.20)
Alternative name(s):
Maltase
Gene namesi
Name:malA
Ordered Locus Names:Ssol_0793
OrganismiSulfolobus solfataricus (strain 98/2)
Taxonomic identifieri555311 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001493: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 700700Alpha-glucosidasePRO_0000391339Add
BLAST

Expressioni

Inductioni

Expressed during growth on maltose.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Phylogenomic databases

HOGENOMiHOG000033867.
KOiK01187.
OMAiIIMKQAG.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0KQM8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTIKIYENK GVYKVVIGEP FPPIEFPLEQ KISSNKSLSE LGLTIVQQGN
60 70 80 90 100
KVIVEKSLDL KEHIIGLGEK AFELDRKRKR YVMYNVDAGA YKKYQDPLYV
110 120 130 140 150
SIPLFISVKD GVATGYFFNS ASKVIFDVGL EEYDKVIVTI PEDSVEFYVI
160 170 180 190 200
EGPRIEDVLE KYTELTGKPF LPPMWAFGYM ISRYSYYPQD KVVELVDIMQ
210 220 230 240 250
KEGFRVAGVF LDIHYMDSYK LFTWHPYRFP EPKKLIDELH KRNVKLITIV
260 270 280 290 300
DHGIRVDQNY SPFLSGMGKF CEIESGELFV GKMWPGTTVY PDFFREDTRE
310 320 330 340 350
WWAGLISEWL SQGVDGIWLD MNEPTDFSRA IEIRDVLSSL PVQFRDDRLV
360 370 380 390 400
TTFPDNVVHY LRGKRVKHEK VRNAYPLYEA MATFKGFRTS HRNEIFILSR
410 420 430 440 450
AGYAGIQRYA FIWTGDNTPS WDDLKLQLQL VLGLSISGVP FVGCDIGGFQ
460 470 480 490 500
GRNFAEIDNS MDLLVKYYAL ALFFPFYRSH KATDGIDTEP VFLPDYYKEK
510 520 530 540 550
VKEIVELRYK FLPYIYSLAL EASEKGHPVI RPLFYEFQDD DDMYRIEDEY
560 570 580 590 600
MVGKYLLYAP IVSKEESRLV TLPRGKWYNY WNGEIINGKS VVKSTHELPI
610 620 630 640 650
YLREGSIIPL EGDELIVYGE TSFKRYDNAE ITSSSNEIKF SREIYVSKLT
660 670 680 690 700
ITSEKPVSKI IVDDSKEIQV EKTMQNTYVA KINQKIRGKI NLEGSVLKQS
Length:700
Mass (Da):81,141
Last modified:December 15, 2009 - v1
Checksum:i8F329E799CA542B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti694 – 7007Missing in AAC38215. (PubMed:9495770)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042494 Genomic DNA. Translation: AAC38215.1.
CP001800 Genomic DNA. Translation: ACX91047.1.
RefSeqiYP_005642648.1. NC_017274.1.

Genome annotation databases

EnsemblBacteriaiACX91047; ACX91047; Ssol_0793.
GeneIDi12258172.
KEGGisol:Ssol_0793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042494 Genomic DNA. Translation: AAC38215.1 .
CP001800 Genomic DNA. Translation: ACX91047.1 .
RefSeqi YP_005642648.1. NC_017274.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH31. Glycoside Hydrolase Family 31.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACX91047 ; ACX91047 ; Ssol_0793 .
GeneIDi 12258172.
KEGGi sol:Ssol_0793.

Phylogenomic databases

HOGENOMi HOG000033867.
KOi K01187.
OMAi IIMKQAG.

Enzyme and pathway databases

BioCyci SSOL555311:GLLY-794-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
InterProi IPR013785. Aldolase_TIM.
IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the alpha-glucosidase gene (malA) from the hyperthermophilic archaeon Sulfolobus solfataricus."
    Rolfsmeier M., Haseltine C., Bini E., Clark A., Blum P.
    J. Bacteriol. 180:1287-1295(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-20 AND 552-561, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION.
  2. "Complete sequence of Sulfolobus solfataricus 98/2."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Mead D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 98/2.

Entry informationi

Entry nameiAGLU_SULS9
AccessioniPrimary (citable) accession number: D0KQM8
Secondary accession number(s): O59645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: December 15, 2009
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

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