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Protein

NAD kinase

Gene

nadK

Organism
Pectobacterium parmentieri (strain WPP163) (Pectobacterium wasabiae (strain WPP163))
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79Proton acceptorUniRule annotation1
Binding sitei164NADUniRule annotation1
Binding sitei181NADUniRule annotation1
Binding sitei183NADUniRule annotation1
Binding sitei253NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 80NADUniRule annotation2
Nucleotide bindingi153 – 154NADUniRule annotation2
Nucleotide bindingi194 – 199NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotationSAAS annotation (EC:2.7.1.23UniRule annotationSAAS annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Pecwa_0964Imported
OrganismiPectobacterium parmentieri (strain WPP163) (Pectobacterium wasabiae (strain WPP163))Imported
Taxonomic identifieri561231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaePectobacterium
Proteomesi
  • UP000000315 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi561231.Pecwa_0964.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000227221.
KOiK00858.
OMAiVNLGHVG.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiView protein in InterPro
IPR017438. ATP-NAD_kinase_N.
IPR017437. ATP-NAD_kinase_PpnK-typ_C.
IPR016064. NAD/diacylglycerol_kinase_sf.
IPR002504. NADK.
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiView protein in Pfam
PF01513. NAD_kinase. 1 hit.
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

D0KIF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTPLTMNRP FNCIGIVGHP RHPTALATHE MLYHWLTEKG YSVLIEQQIA
60 70 80 90 100
RELNLKNAPT GSLADIGQQA DLAVVVGGDG NMLGAARVLS RYDIKVIGVN
110 120 130 140 150
RGNLGFLTDL DPDHAQQQLS DVLDGHYLSE QRFMLEAHVC RANQPDSIST
160 170 180 190 200
AINEVVLHPG KVAHMIEFEV YIDDKFAFSQ RSDGLIIATP TGSTAYSLSA
210 220 230 240 250
GGPILTPSLE AIALVPMFPH TLSARPLVIN SSSTIRLKFS CITNDLEISC
260 270 280 290
DSQIALPVQE GEEVLIRRSE HHLNLIHPKN YSYFNTLSSK LGWSKKLF
Length:298
Mass (Da):32,793
Last modified:December 15, 2009 - v1
Checksum:i717EC4F6DB0488B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001790 Genomic DNA. Translation: ACX86781.1.

Genome annotation databases

EnsemblBacteriaiACX86781; ACX86781; Pecwa_0964.
KEGGipwa:Pecwa_0964.

Similar proteinsi

Entry informationi

Entry nameiD0KIF9_PECPW
AccessioniPrimary (citable) accession number: D0KIF9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported