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D0K9E9 (D0K9E9_STAAD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase HAMAP-Rule MF_00583
Short name=RPPK HAMAP-Rule MF_00583
EC=2.7.6.1 HAMAP-Rule MF_00583
Alternative name(s):
Phosphoribosyl pyrophosphate synthase HAMAP-Rule MF_00583
Gene names
Name:prsA EMBL ACY10383.1
Synonyms:prs HAMAP-Rule MF_00583
Ordered Locus Names:SAAV_0447 EMBL ACY10383.1
OrganismStaphylococcus aureus (strain ED98) [Complete proteome] [HAMAP] EMBL ACY10383.1
Taxonomic identifier681288 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583 RuleBase RU004325

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00583

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00583.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family. HAMAP-Rule MF_00583 RuleBase RU004324

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region221 – 234145-phosphoribose 1-diphosphate binding By similarity HAMAP-Rule MF_00583

Sites

Metal binding1351Magnesium By similarity HAMAP-Rule MF_00583
Metal binding1371Magnesium By similarity HAMAP-Rule MF_00583
Metal binding1461Magnesium By similarity HAMAP-Rule MF_00583
Metal binding1501Magnesium By similarity HAMAP-Rule MF_00583

Sequences

Sequence LengthMass (Da)Tools
D0K9E9 [UniParc].

Last modified December 15, 2009. Version 1.
Checksum: 70A955AA62C9415E

FASTA32135,284
        10         20         30         40         50         60 
MLNNEYKNSS LKIFSLKGNE ALAQEVADQV GIELGKCSVK RFSDGEIQIN IEESIRGCDV 

        70         80         90        100        110        120 
FIIQPTSYPV NLHLMELLIM IDACKRASAA TINIVVPYYG YARQDRKARS REPITAKLVA 

       130        140        150        160        170        180 
NLIETAGATR MIALDLHAPQ IQGFFDIPID HLMGVPILAK HFKDDPNINP EECVVVSPDH 

       190        200        210        220        230        240 
GGVTRARKLA DILKTPIAII DKRRPRPNVA EVMNIVGEIE GRTAIIIDDI IDTAGTITLA 

       250        260        270        280        290        300 
AQALKDKGAK EVYACCTHPV LSGPAKERIE NSAIKELIVT NSIHLDEDRK PSNTKELSVA 

       310        320 
GLIAQAIIRV YERESVSVLF D

« Hide

References

[1]"Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus."
Lowder B.V., Guinane C.M., Ben Zakour N.L., Weinert L.A., Conway-Morris A., Cartwright R.A., Simpson A.J., Rambaut A., Nuebel U., Fitzgerald J.R.
Proc. Natl. Acad. Sci. U.S.A. 106:19545-19550(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ED98 EMBL ACY10383.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001781 Genomic DNA. Translation: ACY10383.1.
RefSeqYP_003281389.1. NC_013450.1.

3D structure databases

ProteinModelPortalD0K9E9.
SMRD0K9E9. Positions 10-320.
ModBaseSearch...

Protein-protein interaction databases

STRING681288.SAAV_0447.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACY10383; ACY10383; SAAV_0447.
GeneID8613210.
KEGGsad:SAAV_0447.
PATRIC32444926. VBIStaAur139507_0452.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0462.
HOGENOMHOG000210449.
KOK00948.
OMAYVQIQES.

Enzyme and pathway databases

BioCycSAUR681288:GJ8Z-441-MONOMER.
UniPathwayUPA00087; UER00172.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase_dom.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD0K9E9_STAAD
AccessionPrimary (citable) accession number: D0K9E9
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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