Skip Header

Contribute Send feedback
Read comments (?) or add your own

D0K9E4 (D0K9E4_STAAD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Short name=CMK HAMAP-Rule MF_00061
EC=2.7.1.148 HAMAP-Rule MF_00061
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Gene names
Name:ipk EMBL ACY10378.1
Synonyms:ispE HAMAP-Rule MF_00061
Ordered Locus Names:SAAV_0442 EMBL ACY10378.1
OrganismStaphylococcus aureus (strain ED98) [Complete proteome] [HAMAP] EMBL ACY10378.1
Taxonomic identifier681288 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP-Rule MF_00061 SAAS SAAS004424

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP-Rule MF_00061 SAAS SAAS004424

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP-Rule MF_00061 SAAS SAAS004424

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily. HAMAP-Rule MF_00061

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding93 – 10311ATP By similarity HAMAP-Rule MF_00061

Sites

Active site91 By similarity HAMAP-Rule MF_00061
Active site1351 By similarity HAMAP-Rule MF_00061

Sequences

Sequence LengthMass (Da)Tools
D0K9E4 [UniParc].

Last modified December 15, 2009. Version 1.
Checksum: C8A851AFCC4385AE

FASTA28231,442
        10         20         30         40         50         60 
MIYETAPAKI NFTLDTLFKR NDGYHEIEMI MTTVDLNDRL TFHKRKDRKI VVEIEHNYVP 

        70         80         90        100        110        120 
SNHKNLAYRA AQLFIEQYQL KQGVTISIDK EIPVSAGLAG GSADAAATLR GLNRLFDIGA 

       130        140        150        160        170        180 
SLEELALLGS KIGTDIPFCI YNKTALCTGR GEKIEFLNKP PSAWVILAKP NLGISSPDIF 

       190        200        210        220        230        240 
KLINLDKRYD VHTKMCYEAL ENRDYQQLCQ SLSNRLEPIS VSKHPQIDKL KNNMLKSGAD 

       250        260        270        280 
GALMSGSGPT VYGLARKESQ AKNIYNAVNG CCNEVYLVRL LG

« Hide

References

[1]"Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus."
Lowder B.V., Guinane C.M., Ben Zakour N.L., Weinert L.A., Conway-Morris A., Cartwright R.A., Simpson A.J., Rambaut A., Nuebel U., Fitzgerald J.R.
Proc. Natl. Acad. Sci. U.S.A. 106:19545-19550(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ED98 EMBL ACY10378.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001781 Genomic DNA. Translation: ACY10378.1.
RefSeqYP_003281384.1. NC_013450.1.

3D structure databases

ProteinModelPortalD0K9E4.
SMRD0K9E4. Positions 6-250.
ModBaseSearch...

Protein-protein interaction databases

STRING681288.SAAV_0442.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACY10378; ACY10378; SAAV_0442.
GeneID8613205.
KEGGsad:SAAV_0442.
PATRIC32444914. VBIStaAur139507_0446.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1947.
HOGENOMHOG000019600.
KOK00919.
OMALMGVNEL.

Enzyme and pathway databases

BioCycSAUR681288:GJ8Z-436-MONOMER.
UniPathwayUPA00056; UER00094.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00061. IspE.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00154. ispE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD0K9E4_STAAD
AccessionPrimary (citable) accession number: D0K9E4
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info