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D0K810 (D0K810_STAAD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2 HAMAP MF_00108
EC=2.7.7.60 HAMAP MF_00108
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase 2 HAMAP MF_00108
MEP cytidylyltransferase 2 HAMAP MF_00108
Gene names
Name:ispD_1 EMBL ACY10166.1
Synonyms:ispD2 HAMAP MF_00108
Ordered Locus Names:SAAV_0223
OrganismStaphylococcus aureus (strain ED98) [Complete proteome] [HAMAP]
Taxonomic identifier681288 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108 SAAS SAAS018294 RuleBase RU003490

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108 SAAS SAAS018294 RuleBase RU003490

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108 SAAS SAAS018294

Sequence similarities

Belongs to the IspD family. HAMAP MF_00108 RuleBase RU004393

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Site141Transition state stabilizer By similarity HAMAP MF_00108
Site221Transition state stabilizer By similarity HAMAP MF_00108
Site1601Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108
Site2171Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108

Sequences

Sequence LengthMass (Da)Tools
D0K810 [UniParc].

Last modified December 15, 2009. Version 1.
Checksum: B19F7EA82D847A0F

FASTA23826,657
        10         20         30         40         50         60 
MKYAGILAGG IGSRMGNVPL PKQFLDLDNK PILIHTLEKF ILINDFEKII IATPQQWMTH 

        70         80         90        100        110        120 
TKDTLRKFKI SDERIEVIQG GSDRNDTIMN IVKHIESTNG INDDDVIVTH DAVRPFLTHR 

       130        140        150        160        170        180 
IIKENIQAAL EYGAVDTVID AIDTIVTSKD NQTIDAIPVR NEMYQGQTPQ SFNINLLKES 

       190        200        210        220        230 
YAQLSDEQKS ILSDACKIIV ETNKPVRLVK GELYNIKVTT PYDLKVANAI IRGGIADD

« Hide

References

[1]"Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus."
Lowder B.V., Guinane C.M., Ben Zakour N.L., Weinert L.A., Conway-Morris A., Cartwright R.A., Simpson A.J., Rambaut A., Nubel U., Fitzgerald J.R.
Proc. Natl. Acad. Sci. U.S.A. 106:19545-19550(2009) [PubMed: 19884497] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001781 Genomic DNA. Translation: ACY10166.1.
RefSeqYP_003281172.1. NC_013450.1.

3D structure databases

ProteinModelPortalD0K810.
ModBaseSearch...

Protein-protein interaction databases

STRINGD0K810.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000057730; EBSTAP00000055013; EBSTAG00000057321.
GeneID8612987.
GenomeReviewsGene locus SAAV_0223 in contig CP001781_GR.
KEGGsad:SAAV_0223.
PATRIC32444470. VBIStaAur139507_0228.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000024510.
OMAREQQDFW.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD0K810_STAAD
AccessionPrimary (citable) accession number: D0K810
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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