D0K7G2 (D0K7G2_STAAD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
EC=1.1.1.17 HAMAP MF_00196

Gene names

Name:	mtlD HAMAP MF_00196 EMBL ACY12056.1
Ordered Locus Names:	SAAV_2213

Organism

Staphylococcus aureus (strain ED98) [Complete proteome] [HAMAP]

Taxonomic identifier

681288 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196 SAAS SAAS000669
Sequence similarities	Belongs to the mannitol dehydrogenase family. HAMAP MF_00196

Ontologies

Keywords
Ligand	NAD HAMAP MF_00196 SAAS SAAS000669
Molecular function	Oxidoreductase HAMAP MF_00196 SAAS SAAS023028
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity HAMAP MF_00196

Sequences

	Sequence		Length	Mass (Da)
	D0K7G2 [UniParc]. Last modified December 15, 2009. Version 1. Checksum: ADB3AC9DA1E076A1	FASTA	368	40,966
	10 20 30 40 50 60 MKAVHFGAGN IGRGFIGYIL TDNNVKVTFA DVNEEIINAL AHDHQYDVIL ADESKTTTRV 70 80 90 100 110 120 NNVDAINSMQ PSEALKQAIL EADIITTAVG VNILPIIAKS FAPFLKEKTN HVNIVACENA 130 140 150 160 170 180 IMATDTLKKA VLDITGPLGN NIHFANSAVD RIVPLQKNEN ILDVMVEPFY EWVVEKDAWY 190 200 210 220 230 240 GPELNHIKYV DDLTPYIERK LLTVNTGHAY LAYAGKFAGK ATVLDAVKDS SIEAGLRRVL 250 260 270 280 290 300 AETSQYITNE FDFTEAEQAG YVEKIIDRFN NSYLSDEVTR VGRGTLRKIG PKDRIIKPLT 310 320 330 340 350 360 YLYNKDLERT GLLNTAALLL KYDDTADQET VEKNNYIKEH GLKAFLSEYA KVDDGLADEI IEAYNSLS

References

[1]

"Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus." Lowder B.V., Guinane C.M., Ben Zakour N.L., Weinert L.A., Conway-Morris A., Cartwright R.A., Simpson A.J., Rambaut A., Nubel U., Fitzgerald J.R. Proc. Natl. Acad. Sci. U.S.A. 106:19545-19550(2009) [PubMed: 19884497] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001781 Genomic DNA. Translation: ACY12056.1.
RefSeq	YP_003283062.1. NC_013450.1.
3D structure databases
ProteinModelPortal	D0K7G2.
ModBase	Search...
Protein-protein interaction databases
STRING	D0K7G2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000056614; EBSTAP00000053417; EBSTAG00000055703.
GeneID	8614950.
GenomeReviews	Gene locus SAAV_2213 in contig CP001781_GR.
KEGG	sad:SAAV_2213.
PATRIC	32448492. VBIStaAur139507_2177.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000024485.
OMA	FANTAVD.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR023027. Mannitol_DH_CS. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00009.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D0K7G2_STAAD

Accession

Primary (citable) accession number: D0K7G2

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2009
Last sequence update:	December 15, 2009
Last modified:	December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)