Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

D0K6Y1 (D0K6Y1_STAAD) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase HAMAP-Rule MF_00228

EC=2.7.1.50 HAMAP-Rule MF_00228
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase HAMAP-Rule MF_00228
Gene names
Name:thiM HAMAP-Rule MF_00228 EMBL ACY11991.1
Ordered Locus Names:SAAV_2146 EMBL ACY11991.1
OrganismStaphylococcus aureus (strain ED98) [Complete proteome] [HAMAP] EMBL ACY11991.1
Taxonomic identifier681288 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228 SAAS SAAS000417

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228 SAAS SAAS000417

Sequence similarities

Belongs to the Thz kinase family. HAMAP-Rule MF_00228

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site391Substrate; via amide nitrogen By similarity HAMAP-Rule MF_00228
Binding site1151ATP By similarity HAMAP-Rule MF_00228
Binding site1601ATP By similarity HAMAP-Rule MF_00228
Binding site1871Substrate; via amide nitrogen By similarity HAMAP-Rule MF_00228

Sequences

Sequence LengthMass (Da)Tools
D0K6Y1 [UniParc].

Last modified December 15, 2009. Version 1.
Checksum: B7D8DD02F2D8E98E

FASTA26328,067
        10         20         30         40         50         60 
MNYLNKIRIE NPLTICYTND VVKNFTANGL LSIGASPAMS EAPEEAEEFY KVAQALLINI 

        70         80         90        100        110        120 
GTLTAQNEQD IIAIAQTANE AGLPIVFDPV AVGASTYRKQ FCKLLLKSAK VSVIKGNASE 

       130        140        150        160        170        180 
ILALIDDTAT MKGTDSDANL DAVAIAKKAY AIYKTAIVIT GKEDVIVQDN KAIVLANGSP 

       190        200        210        220        230        240 
LLARVTGAGC LLGGVIAGFL FRETEPDIEA LIEAVSVFNI AAEVAAENEN CGGPGTFSPL 

       250        260 
LLDTLYHLNE TTYQQRIRIQ EVE 

« Hide

References

[1]"Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus."
Lowder B.V., Guinane C.M., Ben Zakour N.L., Weinert L.A., Conway-Morris A., Cartwright R.A., Simpson A.J., Rambaut A., Nubel U., Fitzgerald J.R.
Proc. Natl. Acad. Sci. U.S.A. 106:19545-19550(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ED98 EMBL ACY11991.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001781 Genomic DNA. Translation: ACY11991.1.
RefSeqYP_003282997.1. NC_013450.1.

3D structure databases

ProteinModelPortalD0K6Y1.
SMRD0K6Y1. Positions 4-262.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING681288.SAAV_2146.

Proteomic databases

PRIDED0K6Y1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACY11991; ACY11991; SAAV_2146.
GeneID8614885.
KEGGsad:SAAV_2146.
PATRIC32448360. VBIStaAur139507_2111.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycSAUR681288:GJ8Z-2119-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameD0K6Y1_STAAD
AccessionPrimary (citable) accession number: D0K6Y1
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: February 19, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)