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D0K6V8

- D0K6V8_STAAD

UniProt

D0K6V8 - D0K6V8_STAAD

Protein

Alanine racemase

Gene

alr

Organism
Staphylococcus aureus (strain ED98)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei39 – 391Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei138 – 1381SubstrateUniRule annotation
    Active sitei265 – 2651Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei312 – 3121Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSAUR681288:GJ8Z-2096-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:SAAV_2123Imported
    OrganismiStaphylococcus aureus (strain ED98)Imported
    Taxonomic identifieri681288 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002570: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei39 – 391N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi681288.SAAV_2123.

    Structurei

    3D structure databases

    ProteinModelPortaliD0K6V8.
    SMRiD0K6V8. Positions 2-382.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiIYSHLAL.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D0K6V8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDKYYRSAY MNVDLNAVAS NFKVFSTLHP NKTVMAVVKA NAYGLGSVKV    50
    ARHLMENGAT FFAVATLDEA IELRMHGITA KILVLGVLPA KDIDKAIQHR 100
    VALTVPSKQW LKEAIKNISG EQEKKLWLHI KLDTGMGRLG IKDTNTYQEV 150
    IEIIQQYEQL VFEGVFTHFA CADEPGDMTT EQYQRFKDMV NEAIKPEYIH 200
    CQNSAGSLLM DCQFCNAIRP GISLYGYYPS EYVQQKVKVH LKPSVQLIAN 250
    VVQTKTLQAG ESVSYGATYT ATDPTTIALL PIGYADGYLR IMQGSFVNVN 300
    GHQCEVIGRV CMDQTIVKVP DQVKAGDSVI LIDNHRESPQ SVEVVAEKQH 350
    TINYEVLCNL SRRLPRIYHD GDQRFVTNEL LK 382
    Length:382
    Mass (Da):42,809
    Last modified:December 15, 2009 - v1
    Checksum:iA46B7E55F5A65E41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001781 Genomic DNA. Translation: ACY11968.1.
    RefSeqiYP_003282974.1. NC_013450.1.

    Genome annotation databases

    EnsemblBacteriaiACY11968; ACY11968; SAAV_2123.
    GeneIDi8614862.
    KEGGisad:SAAV_2123.
    PATRICi32448318. VBIStaAur139507_2090.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001781 Genomic DNA. Translation: ACY11968.1 .
    RefSeqi YP_003282974.1. NC_013450.1.

    3D structure databases

    ProteinModelPortali D0K6V8.
    SMRi D0K6V8. Positions 2-382.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 681288.SAAV_2123.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACY11968 ; ACY11968 ; SAAV_2123 .
    GeneIDi 8614862.
    KEGGi sad:SAAV_2123.
    PATRICi 32448318. VBIStaAur139507_2090.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi IYSHLAL.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci SAUR681288:GJ8Z-2096-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ED98Imported.

    Entry informationi

    Entry nameiD0K6V8_STAAD
    AccessioniPrimary (citable) accession number: D0K6V8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 15, 2009
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3