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D0K4X0 (D0K4X0_STAAD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Dihydrodipicolinate synthase EMBL ACY11280.1
Gene names
Name:dapA EMBL ACY11280.1
Ordered Locus Names:SAAV_1378
OrganismStaphylococcus aureus (strain ED98) [Complete proteome] [HAMAP]
Taxonomic identifier681288 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. SAAS SAAS005263

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. SAAS SAAS005263

Subunit structure

Homotetramer By similarity. SAAS SAAS005263

Subcellular location

Cytoplasm By similarity SAAS SAAS005263.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis SAAS SAAS005263
Lysine biosynthesis SAAS SAAS005263
   Cellular componentCytoplasm SAAS SAAS005263
   LigandSchiff base SAAS SAAS005263
   Molecular functionLyase SAAS SAAS005263
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
D0K4X0 [UniParc].

Last modified December 15, 2009. Version 1.
Checksum: EAD1E6DD4CE05A17

FASTA29532,660
        10         20         30         40         50         60 
MTHLFEGVGV ALTTPFTNNK VNLEALKAHV NFLLENNAQA IIVNGTTAES PTLTTDEKER 

        70         80         90        100        110        120 
ILKTVIDLVD KRVPVIAGTG TNDTEKSIQA SFQAKALGAD AIMLITPYYN KTNQRGLVKH 

       130        140        150        160        170        180 
FEAITDAVKL PVVLYNVPSR TNMTIEPETV EILSQHPYIV ALKDATNDFE YLEEVKKRID 

       190        200        210        220        230        240 
TNSFALYSGN DDNVVEYYQR GGQGVISVIA NVIPKEFQAL YDAQQSGLDI QDQFKPIGTL 

       250        260        270        280        290 
LSALSVDINP IPIKALTSYL EFGNYELRLP LVSLEDTDTK VLREAYDTFK AGENE

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References

[1]"Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus."
Lowder B.V., Guinane C.M., Ben Zakour N.L., Weinert L.A., Conway-Morris A., Cartwright R.A., Simpson A.J., Rambaut A., Nubel U., Fitzgerald J.R.
Proc. Natl. Acad. Sci. U.S.A. 106:19545-19550(2009) [PubMed: 19884497] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001781 Genomic DNA. Translation: ACY11280.1.
RefSeqYP_003282286.1. NC_013450.1.

3D structure databases

ProteinModelPortalD0K4X0.
SMRD0K4X0. Positions 2-293.
ModBaseSearch...

Protein-protein interaction databases

STRINGD0K4X0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000056947; EBSTAP00000053965; EBSTAG00000057017.
GeneID8614125.
GenomeReviewsGene locus SAAV_1378 in contig CP001781_GR.
KEGGsad:SAAV_1378.
PATRIC32446803. VBIStaAur139507_1376.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000024245.
OMATIHFTHI.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD0K4X0_STAAD
AccessionPrimary (citable) accession number: D0K4X0
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: December 14, 2011
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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