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D0K3K0 (D0K3K0_STAAD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--poly(phosphoribitol) ligase subunit 1 HAMAP-Rule MF_00593
EC=6.1.1.13 HAMAP-Rule MF_00593
Alternative name(s):
D-alanine-D-alanyl carrier protein ligase HAMAP-Rule MF_00593
D-alanine-activating enzyme HAMAP-Rule MF_00593
Gene names
Name:dltA HAMAP-Rule MF_00593 EMBL ACY10810.1
Ordered Locus Names:SAAV_0893 EMBL ACY10810.1
OrganismStaphylococcus aureus (strain ED98) [Complete proteome] [HAMAP] EMBL ACY10810.1
Taxonomic identifier681288 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp By similarity. HAMAP-Rule MF_00593 SAAS SAAS010071

Catalytic activity

ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate). HAMAP-Rule MF_00593 SAAS SAAS010071

Pathway

Cell wall biogenesis; lipoteichoic acid biosynthesis. HAMAP-Rule MF_00593 SAAS SAAS010071

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00593 SAAS SAAS010071.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily. HAMAP-Rule MF_00593

Sequences

Sequence LengthMass (Da)Tools
D0K3K0 [UniParc].

Last modified December 15, 2009. Version 1.
Checksum: 3E2DB528D8211794

FASTA48554,644
        10         20         30         40         50         60 
MTDIINKLQA FADANPQSIA VRHTTDELTY QQLMDESSKL AHRLQGSKKP MILFGHMSPY 

        70         80         90        100        110        120 
MIVGMIGAIK AGCGYVPVDT SIPEDRIKMI INKVQPEFVF NTTDESFESL EGEVFTIEDI 

       130        140        150        160        170        180 
KTSQDPVIFD SQIKDNDTVY TIFTSGSTGE PKGVQIEYAS LVQFTEWMLE LNKSGNKQQW 

       190        200        210        220        230        240 
LNQAPFSFDL SVMAIYPCLA SGGTLNLVDK NMINKPKLLN EMLTATPINI WVSTPSFMEM 

       250        260        270        280        290        300 
CLLLPTLNEE QYGSLNEFFF CGEILPHRAA KALVSRFPSA TIYNTYGPTE ATVAVTSIQI 

       310        320        330        340        350        360 
TQEILDQYPT LPVGVERLGA RLSTTDDGEL VIEGQSVSLG YLKNDQKTAE VFNFDDGIRT 

       370        380        390        400        410        420 
YHTGDKAKFE NGQWFIQGRI DFQIKLNGYR MELEEIETQL RQSEFVKEAI VVPVYKNDKV 

       430        440        450        460        470        480 
IHLIGAIVPT TEVTDNAEMT KNIKNDLKSR LPEYMIPRKF EWMEQLPLTS NGKIDRKKIA 


EVING

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References

[1]"Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus."
Lowder B.V., Guinane C.M., Ben Zakour N.L., Weinert L.A., Conway-Morris A., Cartwright R.A., Simpson A.J., Rambaut A., Nuebel U., Fitzgerald J.R.
Proc. Natl. Acad. Sci. U.S.A. 106:19545-19550(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ED98 EMBL ACY10810.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001781 Genomic DNA. Translation: ACY10810.1.
RefSeqYP_003281816.1. NC_013450.1.

3D structure databases

ProteinModelPortalD0K3K0.
SMRD0K3K0. Positions 4-483.
ModBaseSearch...

Protein-protein interaction databases

STRING681288.SAAV_0893.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACY10810; ACY10810; SAAV_0893.
GeneID8613651.
KEGGsad:SAAV_0893.
PATRIC32445834. VBIStaAur139507_0895.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1020.
HOGENOMHOG000229995.
KOK03367.
OMADALACYL.

Enzyme and pathway databases

BioCycSAUR681288:GJ8Z-884-MONOMER.
UniPathwayUPA00556.

Family and domain databases

HAMAPMF_00593. DltA.
InterProIPR010071. AA_adenyl_domain.
IPR000873. AMP-dep_Synth/Lig.
IPR010072. D_ala_DACP_lig.
IPR025110. DUF4009.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
PF13193. DUF4009. 1 hit.
[Graphical view]
TIGRFAMsTIGR01733. AA-adenyl-dom. 1 hit.
TIGR01734. D-ala-DACP-lig. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD0K3K0_STAAD
AccessionPrimary (citable) accession number: D0K3K0
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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