D0K383 (D0K383_STAAD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase HAMAP MF_00214
Short name=3-dehydroquinase HAMAP MF_00214
EC=4.2.1.10 HAMAP MF_00214

Alternative name(s):
Type I DHQase HAMAP MF_00214

Gene names

Name:	aroD HAMAP MF_00214 EMBL ACY10693.1
Ordered Locus Names:	SAAV_0775

Organism

Staphylococcus aureus (strain ED98) [Complete proteome] [HAMAP]

Taxonomic identifier

681288 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family. HAMAP MF_00214

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00214
Ligand	Schiff base HAMAP MF_00214
Molecular function	Lyase HAMAP MF_00214
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	133	1	Proton acceptor By similarity HAMAP MF_00214
	Active site	160	1	Schiff-base intermediate with substrate By similarity HAMAP MF_00214

Sequences

	Sequence		Length	Mass (Da)
	D0K383 [UniParc]. Last modified December 15, 2009. Version 1. Checksum: 2426E26085315671	FASTA	238	26,964
	10 20 30 40 50 60 MTHVEVVATI APQLSIEETL IQKINHRIDA IDVLELRIDQ IENVTVDQVA EMITKLKVMQ 70 80 90 100 110 120 DSFKLLVTYR TKLQGGYGQF INDLYLNLIS DLANINGIDM IDIEWQADID IEKHQRIIKH 130 140 150 160 170 180 LQQYNKEVVI SHHNFESTPP LDELQFIFFK MQKFNPEYVK LAVMPHNKND VLNLLQAMST 190 200 210 220 230 FSDTMDCKVV GISMSKLGLI SRTAQGVFGG ALTYGCIGEP QAPGQIDVTD LKAQVTLY

References

[1]

"Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus." Lowder B.V., Guinane C.M., Ben Zakour N.L., Weinert L.A., Conway-Morris A., Cartwright R.A., Simpson A.J., Rambaut A., Nubel U., Fitzgerald J.R. Proc. Natl. Acad. Sci. U.S.A. 106:19545-19550(2009) [PubMed: 19884497] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001781 Genomic DNA. Translation: ACY10693.1.
RefSeq	YP_003281699.1. NC_013450.1.
3D structure databases
ProteinModelPortal	D0K383.
SMR	D0K383. Positions 3-238.
ModBase	Search...
Protein-protein interaction databases
STRING	D0K383.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000057113; EBSTAP00000054210; EBSTAG00000057336.
GeneID	8613534.
GenomeReviews	Gene locus SAAV_0775 in contig CP001781_GR.
KEGG	sad:SAAV_0775.
PATRIC	32445588. VBIStaAur139507_0771.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000025297.
OMA	IAKIAVM.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D0K383_STAAD

Accession

Primary (citable) accession number: D0K383

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2009
Last sequence update:	December 15, 2009
Last modified:	December 14, 2011
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)