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D0JWL0

- D0JWL0_YERP1

UniProt

D0JWL0 - D0JWL0_YERP1

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Protein

Alanine racemase

Gene

alr

Organism
Yersinia pestis (strain D182038)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei175 – 1751SubstrateUniRule annotation
Active sitei301 – 3011Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei349 – 3491Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciYPES637385:GLMY-2084-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:YPD8_2052Imported
OrganismiYersinia pestis (strain D182038)Imported
Taxonomic identifieri637385 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000002567: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD0JWL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiHVANSYI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0JWL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHVRFRHLFL LPLITLVACS QPVSKNHLSL TSLSANAQQP VVNNAWLEIS
60 70 80 90 100
QGALDFNTKK MLTLLDNKST LCAILKGDAY GHDLTLVTPV MLKNNVQCIG
110 120 130 140 150
VASNQELKTV RDLGFTGQLI RVRSATLKEM QQAMAYDVEE LIGDKTVAEQ
160 170 180 190 200
LNNIAKLNGK VLRIHLALNS AGMSRNGLEV SKARGLNDAK TIAGLKNLTI
210 220 230 240 250
VGIMSHYPVE DASEIKADLA RFQQQAKDVI AVTGLKREKI KLHVANTFAT
260 270 280 290 300
LAVPDSWLDM VRVGGVFYGD TIASTEYKRV MTFKSNIASL NNYPKGGTVG
310 320 330 340 350
YDRTYTLKRD SLLANIPVGY ADGYRRVFSN AGHVIIQGQR LPVLGKTSMN
360 370 380 390 400
TVIVDVTDLK KVSLGDEVVL FGKQGNAEIQ AEEIEDLSGA LFTEMSILWG

ATNKRILVD
Length:409
Mass (Da):44,770
Last modified:December 15, 2009 - v1
Checksum:iBBFCC8C5A2E4241C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001589 Genomic DNA. Translation: ACY62731.1.
RefSeqiYP_005509124.1. NC_017160.1.

Genome annotation databases

EnsemblBacteriaiACY62731; ACY62731; YPD8_2052.
GeneIDi12098400.
KEGGiypx:YPD8_2052.
PATRICi36768414. VBIYerPes93679_2727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001589 Genomic DNA. Translation: ACY62731.1 .
RefSeqi YP_005509124.1. NC_017160.1.

3D structure databases

ProteinModelPortali D0JWL0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACY62731 ; ACY62731 ; YPD8_2052 .
GeneIDi 12098400.
KEGGi ypx:YPD8_2052.
PATRICi 36768414. VBIYerPes93679_2727.

Phylogenomic databases

KOi K01775.
OMAi HVANSYI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci YPES637385:GLMY-2084-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Spatial variation of Yersinia pestis from Yunnan Province of China."
    Zhang Z., Hai R., Song Z., Xia L., Liang Y., Cai H., Liang Y., Shen X., Zhang E., Xu J., Yu D., Yu X.J.
    Am. J. Trop. Med. Hyg. 81:714-717(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D182038Imported.

Entry informationi

Entry nameiD0JWL0_YERP1
AccessioniPrimary (citable) accession number: D0JWL0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: November 26, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3