D0JKI2 (D0JKI2_YERPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Glyoxylate/hydroxypyruvate reductase B HAMAP MF_01667
EC=1.1.1.79 HAMAP MF_01667
EC=1.1.1.81 HAMAP MF_01667

Gene names

Name:	ghrB HAMAP MF_01667
Ordered Locus Names:	YPD4_3590

Organism

Yersinia pestis (strain D106004) [Complete proteome] [HAMAP]

Taxonomic identifier

637382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively By similarity. HAMAP MF_01667
Catalytic activity	D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H. HAMAP MF_01667 SAAS SAAS023756 Glycolate + NADP+ = glyoxylate + NADPH. SAAS SAAS023756 HAMAP MF_01667
Subunit structure	Homodimer By similarity. SAAS SAAS023756 HAMAP MF_01667
Subcellular location	Cytoplasm By similarity HAMAP MF_01667 SAAS SAAS023756.
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. HAMAP MF_01667

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS023756 HAMAP MF_01667
Ligand	NAD SAAS SAAS023756 HAMAP MF_01667 NADP SAAS SAAS023756 HAMAP MF_01667
Molecular function	Oxidoreductase SAAS SAAS023756 HAMAP MF_01667
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro glyoxylate reductase (NADP) activity Inferred from electronic annotation. Source: HAMAP hydroxypyruvate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	237	1	By similarity HAMAP MF_01667
	Active site	266	1	By similarity HAMAP MF_01667
	Active site	285	1	Proton donor By similarity HAMAP MF_01667

Sequences

	Sequence		Length	Mass (Da)
	D0JKI2 [UniParc]. Last modified December 15, 2009. Version 1. Checksum: 935B405A48250AE2	FASTA	326	35,465
	10 20 30 40 50 60 MKPSIVLYKS IPTDLHQRLA QHFTVNSFDG LTPDNQPELL AALQQAEGLI GSGGKIDQDF 70 80 90 100 110 120 LQLAPNLRAA STISVGYDNF DVEALSQRGI ALMHTPTVLT ETVADTMMAL MLSTARRVVE 130 140 150 160 170 180 LAERVKAGEW QESIGDDWFG VDVHHKTIGI LGMGRIGMAL AQRAHFGFSM PVLYTSRRPH 190 200 210 220 230 240 EAAEQRFGAR HCSLDTLLAE ADFLCITLPM TEQTYHMIGR EQLAKMKSSA ILINAGRGPV 250 260 270 280 290 300 VDEQALIAAL QDGTIHAAGL DVFEQEPLPV DSPLLTLRNV VAVPHIGSAT HETRYNMAAC 310 320 AVDNLINALT GTVKENCVNP QVLITH

References

[1]

"Spatial variation of Yersinia pestis from Yunnan Province of China." Zhang Z., Hai R., Song Z., Xia L., Liang Y., Cai H., Liang Y., Shen X., Zhang E., Xu J., Yu D., Yu X.J. Am. J. Trop. Med. Hyg. 81:714-717(2009) [PubMed: 19815893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001585 Genomic DNA. Translation: ACY60492.1.
3D structure databases
ProteinModelPortal	D0JKI2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GenomeReviews	Gene locus YPD4_3590 in contig CP001585_GR.
PATRIC	36762292. VBIYerPes77623_4758.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HALTEKK.
Family and domain databases
HAMAP	MF_01667. 2_Hacid_dh_C_GhrB. [Tree]
InterPro	IPR006139. D-isomer_2_OHA_DH_cat_dom. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR023756. Glyo/OHPyrv_Rdtase_B. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view]
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D0JKI2_YERPD

Accession

Primary (citable) accession number: D0JKI2

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2009
Last sequence update:	December 15, 2009
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)