Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

D0JHA9

- D0JHA9_YERPD

UniProt

D0JHA9 - D0JHA9_YERPD

Protein

Polyamine aminopropyl transferase

Gene

speE

Organism
Yersinia pestis (strain D106004)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (15 Dec 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.UniRule annotation

    Catalytic activityi

    S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331S-adenosylmethioninamineUniRule annotation
    Binding sitei64 – 641PolyamineUniRule annotation
    Binding sitei88 – 881PolyamineUniRule annotation
    Binding sitei108 – 1081S-adenosylmethioninamineUniRule annotation
    Active sitei158 – 1581Proton acceptorUniRule annotation
    Binding sitei165 – 1651S-adenosylmethioninamine; via carbonyl oxygenUniRule annotation

    GO - Molecular functioni

    1. spermidine synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Keywords - Biological processi

    Polyamine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotation

    Enzyme and pathway databases

    BioCyciYPES637382:GLMX-3050-MONOMER.
    UniPathwayiUPA00248; UER00314.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyamine aminopropyl transferaseUniRule annotation
    Alternative name(s):
    Putrescine aminopropyltransferaseUniRule annotation
    Spermidine synthaseUniRule annotation
    Gene namesi
    Name:speEUniRule annotationImported
    Ordered Locus Names:YPD4_2995Imported
    OrganismiYersinia pestis (strain D106004)Imported
    Taxonomic identifieri637382 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000285: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    Keywords - Cellular componenti

    CytoplasmUniRule annotation, Membrane

    Interactioni

    Subunit structurei

    Homodimer or homotetramer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD0JHA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei263 – 28018Helical;UniRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 238234PABSUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni53 – 542Polyamine bindingUniRule annotation
    Regioni140 – 1412S-adenosylmethioninamine bindingUniRule annotation
    Regioni159 – 1613Polyamine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the spermidine/spermine synthase family.UniRule annotation
    Contains 1 PABS (polyamine biosynthesis) domain.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000256146.
    KOiK00797.
    OMAiVEVIDIC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_00198. Spermidine_synth.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR001045. Spermidine/spermine_synthase.
    [Graphical view]
    PANTHERiPTHR11558. PTHR11558. 1 hit.
    PfamiPF01564. Spermine_synth. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00417. speE. 1 hit.
    PROSITEiPS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
    PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D0JHA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQKELWYET LHANFGQYFS VENVLFREKT EHQDLVIFEN PELGRVMALD    50
    GVVQTTERDE FIYHEMMTHV PLLAHGQAKK VLIIGGGDGA MLREVSRHKN 100
    IEQITMVEID AGVVEFCRQY LPNHSAGAYD DPRFKLVIDD GVNFVNQTTE 150
    KFDVIISDCT DPIGPGESLF TSVFYEGCAR SLNEGGIFVA QNGVCFLQQD 200
    EAVNSHNKLS HYFSDVSFYQ AAIPTYYGGI MTFAWATQNP ALRQLDLATL 250
    QNRFAQAGLA CRYYNPAIHV GSFALPQYLL DALTTIPKVI GVDSSE 296
    Length:296
    Mass (Da):33,166
    Last modified:December 15, 2009 - v1
    Checksum:i87108FA1B7F9E018
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001585 Genomic DNA. Translation: ACY59899.1.
    RefSeqiYP_005506202.1. NC_017154.1.

    Genome annotation databases

    EnsemblBacteriaiACY59899; ACY59899; YPD4_2995.
    GeneIDi12095646.
    KEGGiypd:YPD4_2995.
    PATRICi36760679. VBIYerPes77623_3984.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001585 Genomic DNA. Translation: ACY59899.1 .
    RefSeqi YP_005506202.1. NC_017154.1.

    3D structure databases

    ProteinModelPortali D0JHA9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACY59899 ; ACY59899 ; YPD4_2995 .
    GeneIDi 12095646.
    KEGGi ypd:YPD4_2995.
    PATRICi 36760679. VBIYerPes77623_3984.

    Phylogenomic databases

    HOGENOMi HOG000256146.
    KOi K00797.
    OMAi VEVIDIC.

    Enzyme and pathway databases

    UniPathwayi UPA00248 ; UER00314 .
    BioCyci YPES637382:GLMX-3050-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_00198. Spermidine_synth.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR001045. Spermidine/spermine_synthase.
    [Graphical view ]
    PANTHERi PTHR11558. PTHR11558. 1 hit.
    Pfami PF01564. Spermine_synth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00417. speE. 1 hit.
    PROSITEi PS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
    PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Spatial variation of Yersinia pestis from Yunnan Province of China."
      Zhang Z., Hai R., Song Z., Xia L., Liang Y., Cai H., Liang Y., Shen X., Zhang E., Xu J., Yu D., Yu X.J.
      Am. J. Trop. Med. Hyg. 81:714-717(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D106004Imported.

    Entry informationi

    Entry nameiD0JHA9_YERPD
    AccessioniPrimary (citable) accession number: D0JHA9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 15, 2009
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3