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D0JHA9

- D0JHA9_YERPD

UniProt

D0JHA9 - D0JHA9_YERPD

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Protein
Polyamine aminopropyl transferase
Gene
speE, YPD4_2995
Organism
Yersinia pestis (strain D106004)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine By similarity.UniRule annotation

Catalytic activityi

S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331S-adenosylmethioninamine By similarityUniRule annotation
Binding sitei64 – 641Polyamine By similarityUniRule annotation
Binding sitei88 – 881Polyamine By similarityUniRule annotation
Binding sitei108 – 1081S-adenosylmethioninamine By similarityUniRule annotation
Active sitei158 – 1581Proton acceptor By similarityUniRule annotation
Binding sitei165 – 1651S-adenosylmethioninamine; via carbonyl oxygen By similarityUniRule annotation

GO - Molecular functioni

  1. spermidine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Polyamine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciYPES637382:GLMX-3050-MONOMER.
UniPathwayiUPA00248; UER00314.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyamine aminopropyl transferaseUniRule annotation
Alternative name(s):
Putrescine aminopropyltransferase
Spermidine synthase
Gene namesi
Name:speEUniRule annotationImported
Ordered Locus Names:YPD4_2995Imported
OrganismiYersinia pestis (strain D106004)Imported
Taxonomic identifieri637382 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000285: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei263 – 28018Helical; By similarityUniRule annotation
Add
BLAST

Keywords - Cellular componenti

CytoplasmUniRule annotation, Membrane

Interactioni

Subunit structurei

Homodimer or homotetramer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD0JHA9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 238234PABS By similarityUniRule annotation
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Polyamine binding By similarityUniRule annotation
Regioni140 – 1412S-adenosylmethioninamine binding By similarityUniRule annotation
Regioni159 – 1613Polyamine binding By similarityUniRule annotation

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOGENOMiHOG000256146.
KOiK00797.
OMAiVEVIDIC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00198. Spermidine_synth.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR001045. Spermidine/spermine_synthase.
[Graphical view]
PANTHERiPTHR11558. PTHR11558. 1 hit.
PfamiPF01564. Spermine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00417. speE. 1 hit.
PROSITEiPS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0JHA9-1 [UniParc]FASTAAdd to Basket

« Hide

MSQKELWYET LHANFGQYFS VENVLFREKT EHQDLVIFEN PELGRVMALD    50
GVVQTTERDE FIYHEMMTHV PLLAHGQAKK VLIIGGGDGA MLREVSRHKN 100
IEQITMVEID AGVVEFCRQY LPNHSAGAYD DPRFKLVIDD GVNFVNQTTE 150
KFDVIISDCT DPIGPGESLF TSVFYEGCAR SLNEGGIFVA QNGVCFLQQD 200
EAVNSHNKLS HYFSDVSFYQ AAIPTYYGGI MTFAWATQNP ALRQLDLATL 250
QNRFAQAGLA CRYYNPAIHV GSFALPQYLL DALTTIPKVI GVDSSE 296
Length:296
Mass (Da):33,166
Last modified:December 15, 2009 - v1
Checksum:i87108FA1B7F9E018
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001585 Genomic DNA. Translation: ACY59899.1.
RefSeqiYP_005506202.1. NC_017154.1.

Genome annotation databases

EnsemblBacteriaiACY59899; ACY59899; YPD4_2995.
GeneIDi12095646.
KEGGiypd:YPD4_2995.
PATRICi36760679. VBIYerPes77623_3984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001585 Genomic DNA. Translation: ACY59899.1 .
RefSeqi YP_005506202.1. NC_017154.1.

3D structure databases

ProteinModelPortali D0JHA9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACY59899 ; ACY59899 ; YPD4_2995 .
GeneIDi 12095646.
KEGGi ypd:YPD4_2995.
PATRICi 36760679. VBIYerPes77623_3984.

Phylogenomic databases

HOGENOMi HOG000256146.
KOi K00797.
OMAi VEVIDIC.

Enzyme and pathway databases

UniPathwayi UPA00248 ; UER00314 .
BioCyci YPES637382:GLMX-3050-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_00198. Spermidine_synth.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR001045. Spermidine/spermine_synthase.
[Graphical view ]
PANTHERi PTHR11558. PTHR11558. 1 hit.
Pfami PF01564. Spermine_synth. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00417. speE. 1 hit.
PROSITEi PS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Spatial variation of Yersinia pestis from Yunnan Province of China."
    Zhang Z., Hai R., Song Z., Xia L., Liang Y., Cai H., Liang Y., Shen X., Zhang E., Xu J., Yu D., Yu X.J.
    Am. J. Trop. Med. Hyg. 81:714-717(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D106004Imported.

Entry informationi

Entry nameiD0JHA9_YERPD
AccessioniPrimary (citable) accession number: D0JHA9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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