Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

D0JHA9

- D0JHA9_YERPD

UniProt

D0JHA9 - D0JHA9_YERPD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Polyamine aminopropyl transferase

Gene

speE

Organism
Yersinia pestis (strain D106004)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.UniRule annotation

Catalytic activityi

S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331S-adenosylmethioninamineUniRule annotation
Binding sitei64 – 641PolyamineUniRule annotation
Binding sitei88 – 881PolyamineUniRule annotation
Binding sitei108 – 1081S-adenosylmethioninamineUniRule annotation
Active sitei158 – 1581Proton acceptorUniRule annotation
Binding sitei165 – 1651S-adenosylmethioninamine; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

  1. spermidine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Polyamine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciYPES637382:GLMX-3050-MONOMER.
UniPathwayiUPA00248; UER00314.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyamine aminopropyl transferaseUniRule annotation
Alternative name(s):
Putrescine aminopropyltransferaseUniRule annotation
Spermidine synthaseUniRule annotation
Gene namesi
Name:speEUniRule annotationImported
Ordered Locus Names:YPD4_2995Imported
OrganismiYersinia pestis (strain D106004)Imported
Taxonomic identifieri637382 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000285: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, Membrane

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD0JHA9.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei263 – 28018HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 238234PABSUniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Polyamine bindingUniRule annotation
Regioni140 – 1412S-adenosylmethioninamine bindingUniRule annotation
Regioni159 – 1613Polyamine bindingUniRule annotation

Sequence similaritiesi

Belongs to the spermidine/spermine synthase family.UniRule annotation
Contains 1 PABS (polyamine biosynthesis) domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOGENOMiHOG000256146.
KOiK00797.
OMAiVEVIDIC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00198. Spermidine_synth.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR001045. Spermidine/spermine_synthase.
[Graphical view]
PANTHERiPTHR11558. PTHR11558. 1 hit.
PfamiPF01564. Spermine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00417. speE. 1 hit.
PROSITEiPS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0JHA9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQKELWYET LHANFGQYFS VENVLFREKT EHQDLVIFEN PELGRVMALD
60 70 80 90 100
GVVQTTERDE FIYHEMMTHV PLLAHGQAKK VLIIGGGDGA MLREVSRHKN
110 120 130 140 150
IEQITMVEID AGVVEFCRQY LPNHSAGAYD DPRFKLVIDD GVNFVNQTTE
160 170 180 190 200
KFDVIISDCT DPIGPGESLF TSVFYEGCAR SLNEGGIFVA QNGVCFLQQD
210 220 230 240 250
EAVNSHNKLS HYFSDVSFYQ AAIPTYYGGI MTFAWATQNP ALRQLDLATL
260 270 280 290
QNRFAQAGLA CRYYNPAIHV GSFALPQYLL DALTTIPKVI GVDSSE
Length:296
Mass (Da):33,166
Last modified:December 15, 2009 - v1
Checksum:i87108FA1B7F9E018
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001585 Genomic DNA. Translation: ACY59899.1.
RefSeqiYP_005506202.1. NC_017154.1.

Genome annotation databases

EnsemblBacteriaiACY59899; ACY59899; YPD4_2995.
GeneIDi12095646.
KEGGiypd:YPD4_2995.
PATRICi36760679. VBIYerPes77623_3984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001585 Genomic DNA. Translation: ACY59899.1 .
RefSeqi YP_005506202.1. NC_017154.1.

3D structure databases

ProteinModelPortali D0JHA9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACY59899 ; ACY59899 ; YPD4_2995 .
GeneIDi 12095646.
KEGGi ypd:YPD4_2995.
PATRICi 36760679. VBIYerPes77623_3984.

Phylogenomic databases

HOGENOMi HOG000256146.
KOi K00797.
OMAi VEVIDIC.

Enzyme and pathway databases

UniPathwayi UPA00248 ; UER00314 .
BioCyci YPES637382:GLMX-3050-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_00198. Spermidine_synth.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR001045. Spermidine/spermine_synthase.
[Graphical view ]
PANTHERi PTHR11558. PTHR11558. 1 hit.
Pfami PF01564. Spermine_synth. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00417. speE. 1 hit.
PROSITEi PS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Spatial variation of Yersinia pestis from Yunnan Province of China."
    Zhang Z., Hai R., Song Z., Xia L., Liang Y., Cai H., Liang Y., Shen X., Zhang E., Xu J., Yu D., Yu X.J.
    Am. J. Trop. Med. Hyg. 81:714-717(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D106004Imported.

Entry informationi

Entry nameiD0JHA9_YERPD
AccessioniPrimary (citable) accession number: D0JHA9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3