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D0JHA9 (D0JHA9_YERPD) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Spermidine synthase HAMAP-Rule MF_00198 RuleBase RU003837

EC=2.5.1.16 HAMAP-Rule MF_00198 RuleBase RU003837
Alternative name(s):
Putrescine aminopropyltransferase HAMAP-Rule MF_00198
SPDSY HAMAP-Rule MF_00198
Gene names
Name:speE HAMAP-Rule MF_00198 EMBL ACY59899.1
Ordered Locus Names:YPD4_2995 EMBL ACY59899.1
OrganismYersinia pestis (strain D106004) [Complete proteome] [HAMAP] EMBL ACY59899.1
Taxonomic identifier637382 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor By similarity. HAMAP-Rule MF_00198

Catalytic activity

S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine. HAMAP-Rule MF_00198 RuleBase RU003837

Pathway

Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. HAMAP-Rule MF_00198

Subunit structure

Homodimer and homotetramer By similarity. HAMAP-Rule MF_00198

Sequence similarities

Belongs to the spermidine/spermine synthase family. HAMAP-Rule MF_00198 RuleBase RU003836

Contains 1 PABS (polyamine biosynthesis) domain. HAMAP-Rule MF_00198

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain5 – 238234PABS By similarity HAMAP-Rule MF_00198
Region140 – 1412S-adenosylmethioninamine binding By similarity HAMAP-Rule MF_00198

Sites

Active site1581Proton acceptor By similarity HAMAP-Rule MF_00198
Binding site331S-adenosylmethioninamine By similarity HAMAP-Rule MF_00198
Binding site631Putrescine By similarity HAMAP-Rule MF_00198
Binding site881S-adenosylmethioninamine By similarity HAMAP-Rule MF_00198
Binding site1081S-adenosylmethioninamine By similarity HAMAP-Rule MF_00198
Binding site1611Putrescine By similarity HAMAP-Rule MF_00198
Binding site2261Putrescine By similarity HAMAP-Rule MF_00198

Sequences

Sequence LengthMass (Da)Tools
D0JHA9 [UniParc].

Last modified December 15, 2009. Version 1.
Checksum: 87108FA1B7F9E018

FASTA29633,166
        10         20         30         40         50         60 
MSQKELWYET LHANFGQYFS VENVLFREKT EHQDLVIFEN PELGRVMALD GVVQTTERDE 

        70         80         90        100        110        120 
FIYHEMMTHV PLLAHGQAKK VLIIGGGDGA MLREVSRHKN IEQITMVEID AGVVEFCRQY 

       130        140        150        160        170        180 
LPNHSAGAYD DPRFKLVIDD GVNFVNQTTE KFDVIISDCT DPIGPGESLF TSVFYEGCAR 

       190        200        210        220        230        240 
SLNEGGIFVA QNGVCFLQQD EAVNSHNKLS HYFSDVSFYQ AAIPTYYGGI MTFAWATQNP 

       250        260        270        280        290 
ALRQLDLATL QNRFAQAGLA CRYYNPAIHV GSFALPQYLL DALTTIPKVI GVDSSE 

« Hide

References

[1]"Spatial variation of Yersinia pestis from Yunnan Province of China."
Zhang Z., Hai R., Song Z., Xia L., Liang Y., Cai H., Liang Y., Shen X., Zhang E., Xu J., Yu D., Yu X.J.
Am. J. Trop. Med. Hyg. 81:714-717(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D106004 EMBL ACY59899.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001585 Genomic DNA. Translation: ACY59899.1.
RefSeqYP_005506202.1. NC_017154.1.

3D structure databases

ProteinModelPortalD0JHA9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACY59899; ACY59899; YPD4_2995.
GeneID12095646.
KEGGypd:YPD4_2995.
PATRIC36760679. VBIYerPes77623_3984.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000256146.
KOK00797.
OMAELWYTEK.

Enzyme and pathway databases

BioCycYPES637382:GLMX-3050-MONOMER.
UniPathwayUPA00248; UER00314.

Family and domain databases

HAMAPMF_00198. Spermidine_synth.
InterProIPR001045. Spermidine/spermine_synthase.
[Graphical view]
PANTHERPTHR11558. PTHR11558. 1 hit.
PfamPF01564. Spermine_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00417. speE. 1 hit.
PROSITEPS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD0JHA9_YERPD
AccessionPrimary (citable) accession number: D0JHA9
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: February 19, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)