D0JH44 (D0JH44_YERPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
EC=2.4.1.182 HAMAP-Rule MF_00392

Gene names

Name:	lpxB HAMAP-Rule MF_00392 EMBL ACY57833.1
Ordered Locus Names:	YPD4_0924 EMBL ACY57833.1

Organism

Yersinia pestis (strain D106004) [Complete proteome] [HAMAP] EMBL ACY57833.1

Taxonomic identifier

637382 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia › Yersinia pestis

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392 SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392 SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392 SAAS SAAS003835
Sequence similarities	Belongs to the LpxB family. HAMAP-Rule MF_00392

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP-Rule MF_00392 SAAS SAAS003835 Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase HAMAP-Rule MF_00392 SAAS SAAS003835 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D0JH44 [UniParc]. Last modified December 15, 2009. Version 1. Checksum: F4A481D7C188B25C	FASTA	394	43,261
	10 20 30 40 50 60 MQNSPLTADC SLNAGRPLTI GLVAGETSGD ILGAGLIRAL KVQVPNARFV GVAGPLMQAE 70 80 90 100 110 120 GCEAWYEMEE LAVMGVVEVL ERLPRLLKIR KDLTQRFSEL SPDVFVGIDA PDFNITLEGR 130 140 150 160 170 180 LKQRGIRTIH YVSPSVWAWR QKRVFKIGKA TDMVLAFLPF EKAFYDRFNV PCRFIGHTMA 190 200 210 220 230 240 DAMPLVPDQQ AARAELGIAP NATCLALLPG SRHSEVEMLS ADFLRTAVIL RDKLPNLEVV 250 260 270 280 290 300 VPLVNSKRRE QFERIKAEIA PDLSVHLLDG KARVAMIASD AALLASGTAA LECMLAKCPM 310 320 330 340 350 360 VVGYRMKPFT FWLAERLVKT PYVSLPNLLA GEELVTELLQ QECQPQKLAG ALLPLLQGGS 370 380 390 EIAALKERFL VLHQSIRCGA DEQAAQAVLE LADR

References

[1]

"Spatial variation of Yersinia pestis from Yunnan Province of China." Zhang Z., Hai R., Song Z., Xia L., Liang Y., Cai H., Liang Y., Shen X., Zhang E., Xu J., Yu D., Yu X.J. Am. J. Trop. Med. Hyg. 81:714-717(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D106004 EMBL ACY57833.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001585 Genomic DNA. Translation: ACY57833.1.
RefSeq	YP_005504136.1. NC_017154.1.
3D structure databases
ProteinModelPortal	D0JH44.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACY57833; ACY57833; YPD4_0924.
GeneID	12095442.
KEGG	ypd:YPD4_0924.
PATRIC	36755010. VBIYerPes77623_1200.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000018003.
KO	K00748.
OMA	PTVWAWR.
Enzyme and pathway databases
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB.
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D0JH44_YERPD

Accession

Primary (citable) accession number: D0JH44

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2009
Last sequence update:	December 15, 2009
Last modified:	May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)