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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Blattabacterium sp. subsp. Blattella germanica (strain Bge) (Blattella germanica symbiotic bacterium)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotation

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSP331104:GH6K-484-MONOMER.
UniPathwayiUPA00074; UER00131.
UPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotationSAAS annotation (EC:6.3.2.6UniRule annotationSAAS annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotationImported
Ordered Locus Names:BLBBGE_484Imported
OrganismiBlattabacterium sp. subsp. Blattella germanica (strain Bge) (Blattella germanica symbiotic bacterium)Imported
Taxonomic identifieri331104 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesBlattabacteriaceaeBlattabacterium
ProteomesiUP000002625: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi331104.BLBBGE_484.

Structurei

3D structure databases

ProteinModelPortaliD0JBF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0152.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.
OrthoDBiEOG62C9HN.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0JBF3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFVIKKNLL SEGKTKKIYT TNNSLEVLIH YKDSITALDG SKNQFLQDKG
60 70 80 90 100
ILNNEISTLI FKFINSCGIK THFIRKINNR EQLCYKVDII PLEFVVRNIV
110 120 130 140 150
AGSMSKRLNI QEGIRLLNPI FEIFYKNDKL KDPLINDHHA VFLGIISYEE
160 170 180 190 200
INAIYRIVSN VNNILKKYFL DKNIILVDFK IEFGKNDQND ILLSDEISPD
210 220 230 240
TCRFWDKKTM KKLDKDPFRI GLKEKEEVLD IYMEILKRLN VR
Length:242
Mass (Da):28,366
Last modified:December 15, 2009 - v1
Checksum:i127ECE303EECB463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001487 Genomic DNA. Translation: ACY40491.1.
RefSeqiYP_003284101.1. NC_013454.1.

Genome annotation databases

EnsemblBacteriaiACY40491; ACY40491; BLBBGE_484.
GeneIDi8555043.
KEGGibbl:BLBBGE_484.
PATRICi31959608. VBIBlaSp132937_0464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001487 Genomic DNA. Translation: ACY40491.1.
RefSeqiYP_003284101.1. NC_013454.1.

3D structure databases

ProteinModelPortaliD0JBF3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi331104.BLBBGE_484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACY40491; ACY40491; BLBBGE_484.
GeneIDi8555043.
KEGGibbl:BLBBGE_484.
PATRICi31959608. VBIBlaSp132937_0464.

Phylogenomic databases

eggNOGiCOG0152.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.
OrthoDBiEOG62C9HN.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.
UPA00074; UER00131.
BioCyciBSP331104:GH6K-484-MONOMER.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolutionary convergence and nitrogen metabolism in Blattabacterium strain Bge, primary endosymbiont of the cockroach Blattella germanica."
    Lopez-Sanchez M.J., Neef A., Pereto J., Patino-Navarrete R., Pignatelli M., Latorre A., Moya A.
    PLoS Genet. 5:E1000721-E1000721(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BgeImported.

Entry informationi

Entry nameiD0JBF3_BLASB
AccessioniPrimary (citable) accession number: D0JBF3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: February 4, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.