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D0J9G5

- D0J9G5_BLASP

UniProt

D0J9G5 - D0J9G5_BLASP

Protein

Enolase

Gene

eno

Organism
Blattabacterium sp. subsp. Periplaneta americana (strain BPLAN) (Periplaneta americana symbiotic bacterium)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.UniRule annotation

    Catalytic activityi

    2-phospho-D-glycerate = phosphoenolpyruvate + H2O.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Enzyme regulationi

    The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei154 – 1541SubstrateUniRule annotation
    Binding sitei163 – 1631SubstrateUniRule annotation
    Active sitei204 – 2041Proton donorUniRule annotation
    Metal bindingi241 – 2411MagnesiumUniRule annotation
    Metal bindingi290 – 2901MagnesiumUniRule annotation
    Binding sitei290 – 2901SubstrateUniRule annotation
    Metal bindingi317 – 3171MagnesiumUniRule annotation
    Binding sitei317 – 3171SubstrateUniRule annotation
    Active sitei342 – 3421Proton acceptorUniRule annotation
    Binding sitei342 – 3421Substrate (covalent); in inhibited formUniRule annotation
    Binding sitei393 – 3931SubstrateUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphopyruvate hydratase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Biological processi

    GlycolysisUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciBSP600809:GHSF-374-MONOMER.
    UniPathwayiUPA00109; UER00187.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EnolaseUniRule annotation (EC:4.2.1.11UniRule annotation)
    Alternative name(s):
    2-phospho-D-glycerate hydro-lyaseUniRule annotation
    2-phosphoglycerate dehydrataseUniRule annotation
    Gene namesi
    Name:enoUniRule annotationImported
    Ordered Locus Names:BPLAN_372Imported
    OrganismiBlattabacterium sp. subsp. Periplaneta americana (strain BPLAN) (Periplaneta americana symbiotic bacterium)Imported
    Taxonomic identifieri600809 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesBlattabacteriaceaeBlattabacterium
    ProteomesiUP000002225: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation. Secreted UniRule annotation. Cell surface UniRule annotation
    Note: Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.UniRule annotation

    GO - Cellular componenti

    1. cell surface Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell
    3. phosphopyruvate hydratase complex Source: InterPro

    Keywords - Cellular componenti

    CytoplasmUniRule annotation, SecretedUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi600809.BPLAN_372.

    Structurei

    3D structure databases

    ProteinModelPortaliD0J9G5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni369 – 3724Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the enolase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0148.
    HOGENOMiHOG000072174.
    KOiK01689.
    OMAiQVEVYTE.
    OrthoDBiEOG65J589.

    Family and domain databases

    Gene3Di3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    HAMAPiMF_00318. Enolase.
    InterProiIPR000941. Enolase.
    IPR020810. Enolase_C.
    IPR029065. Enolase_C-like.
    IPR020809. Enolase_CS.
    IPR020811. Enolase_N.
    IPR029017. Enolase_N_like.
    [Graphical view]
    PANTHERiPTHR11902. PTHR11902. 1 hit.
    PfamiPF00113. Enolase_C. 1 hit.
    PF03952. Enolase_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001400. Enolase. 1 hit.
    PRINTSiPR00148. ENOLASE.
    SUPFAMiSSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    TIGRFAMsiTIGR01060. eno. 1 hit.
    PROSITEiPS00164. ENOLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D0J9G5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKIKTIKAR QILDSRGNPT VEVDVVTEKN VLGRASVPSG ASKGENEAFE    50
    LRDGGEKFLG NGVMKAVHNV NNIIAPELIG FSVMDQISID KLILDLDGTK 100
    NKKRLGANAI LGVSLAVVKA ASKELNLPLY KYIGGVHAHI LPIPLMNIVN 150
    GGRHSDAPIA FQEFMIVPMR ANTFLDAIQM GYKVFYKLKN ILSKKGLSTN 200
    VGDEGGFSSN FNGIEDVLDN ILEAIHQANY EPYEQIGLAL DCAASEFYQD 250
    EKYNYSKFEK ENKEKVERSK EEHVNYLSYL TRRYPIISIE DGMDQNDWEG 300
    WKMLTRELGK EVLLVGDDLF VTKVEKLNEG IKEGIANSIL IKVNQVGTLT 350
    ETIATINTGK ENGYCNIISH RSGDTEDSFI ADLSVALNIG RIKTGSICRS 400
    ERTSKYNQLL RIEDMLGKNS HYPEWTG 427
    Length:427
    Mass (Da):47,443
    Last modified:December 15, 2009 - v1
    Checksum:i18E2F2EED017663E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001429 Genomic DNA. Translation: ACX83986.1.
    RefSeqiYP_003257129.1. NC_013418.2.

    Genome annotation databases

    EnsemblBacteriaiACX83986; ACX83986; BPLAN_372.
    GeneIDi8528103.
    KEGGibpi:BPLAN_372.
    PATRICi31960689. VBIBlaSp127104_0376.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001429 Genomic DNA. Translation: ACX83986.1 .
    RefSeqi YP_003257129.1. NC_013418.2.

    3D structure databases

    ProteinModelPortali D0J9G5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 600809.BPLAN_372.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACX83986 ; ACX83986 ; BPLAN_372 .
    GeneIDi 8528103.
    KEGGi bpi:BPLAN_372.
    PATRICi 31960689. VBIBlaSp127104_0376.

    Phylogenomic databases

    eggNOGi COG0148.
    HOGENOMi HOG000072174.
    KOi K01689.
    OMAi QVEVYTE.
    OrthoDBi EOG65J589.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00187 .
    BioCyci BSP600809:GHSF-374-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    HAMAPi MF_00318. Enolase.
    InterProi IPR000941. Enolase.
    IPR020810. Enolase_C.
    IPR029065. Enolase_C-like.
    IPR020809. Enolase_CS.
    IPR020811. Enolase_N.
    IPR029017. Enolase_N_like.
    [Graphical view ]
    PANTHERi PTHR11902. PTHR11902. 1 hit.
    Pfami PF00113. Enolase_C. 1 hit.
    PF03952. Enolase_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001400. Enolase. 1 hit.
    PRINTSi PR00148. ENOLASE.
    SUPFAMi SSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    TIGRFAMsi TIGR01060. eno. 1 hit.
    PROSITEi PS00164. ENOLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nitrogen recycling and nutritional provisioning by Blattabacterium, the cockroach endosymbiont."
      Sabree Z.L., Kambhampati S., Moran N.A.
      Proc. Natl. Acad. Sci. U.S.A. 106:19521-19526(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BPLANImported.

    Entry informationi

    Entry nameiD0J9G5_BLASP
    AccessioniPrimary (citable) accession number: D0J9G5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 15, 2009
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3