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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

CtCNB1_2815

Organism
Comamonas testosteroni (strain CNB-2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei550 – 5501SubstrateUniRule annotation
Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCTES543891:GJCV-2874-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported
Gene namesi
Ordered Locus Names:CtCNB1_2815Imported
OrganismiComamonas testosteroni (strain CNB-2)Imported
Taxonomic identifieri688245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeComamonas
ProteomesiUP000002360 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi688245.CtCNB1_2815.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiNSGQMWG.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

D0IZV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQQPTIIY TLTDEAPRLA TSAFLPVIRA FAAPAGINVE TSDISLAGRI
60 70 80 90 100
LGEFPDFLTE AQRAPNNLAE LGKLTLTPEA NIIKLPNISA SVGQLQEAIK
110 120 130 140 150
ELQGKGYAIP DYPETATTDA EKDIKARYNK CIGSAVNPVL REGNSDRRAP
160 170 180 190 200
AAVKNYAKKH PHSMGEWKQW SQTHVSHMEE GDFYHGEKSM TLDKAREVKM
210 220 230 240 250
VLETKSGNSI VLKDKVKLQA AEVIDSMFMS KKALCAFYEK EIEDCRESGI
260 270 280 290 300
LFSLHVKATM MKVSHPIVFG HCVKIFYKEA FEKHGKLFDQ LGVNVNNGMA
310 320 330 340 350
NLYEKIETLP ASQREEIIRD LHKCQEHRPR LAMVDSAKGI TNFHSPNDVI
360 370 380 390 400
VDASMPAMIR VGGKMWAADG KPYDCKAVMP ESTFARIYQE VINFCKWHGN
410 420 430 440 450
FDPKTMGTVP NVGLMAQKAE EYGSHDKTFE IAEDGVANIV DIATGEVLLS
460 470 480 490 500
QNVEAGDIWR MCQVKDAPIR DWVKLAVTRA RNSGMPAVFW LDPYRPHEAE
510 520 530 540 550
LIKKVQTYLK EYDTNGLEIH ILSQVRAMRY TLERVARGLD TISVTGNILR
560 570 580 590 600
DYLTDLFPIL ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVQQLVEEN
610 620 630 640 650
HLRWDSLGEF LALAVSFEDL GIKENNARAK LLAKTLDEAT GKLLDEDKSP
660 670 680 690 700
SRRTGELDNR GSQFYIALYW AQALAAQTED AALAAKFAPL AKSLTENEAK
710 720 730 740
IVAEMKEVQG KAADIGGYYM PDVAKLDAVM RPSATFNAAI ASV
Length:743
Mass (Da):82,151
Last modified:December 15, 2009 - v1
Checksum:i02ECB30F7886D652
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001220 Genomic DNA. Translation: ACY33561.1.
RefSeqiWP_003067431.1. NC_013446.2.

Genome annotation databases

EnsemblBacteriaiACY33561; ACY33561; CtCNB1_2815.
GeneIDi8562614.
KEGGictt:CtCNB1_2815.
PATRICi35266682. VBIComTes153857_2994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001220 Genomic DNA. Translation: ACY33561.1.
RefSeqiWP_003067431.1. NC_013446.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi688245.CtCNB1_2815.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACY33561; ACY33561; CtCNB1_2815.
GeneIDi8562614.
KEGGictt:CtCNB1_2815.
PATRICi35266682. VBIComTes153857_2994.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiNSGQMWG.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciCTES543891:GJCV-2874-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome of Comamonas testosteroni reveals its genetic adaptations to changing environments."
    Ma Y.F., Zhang Y., Zhang J.Y., Chen D.W., Zhu Y., Zheng H., Wang S.Y., Jiang C.Y., Zhao G.P., Liu S.J.
    Appl. Environ. Microbiol. 75:6812-6819(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNB-2Imported.

Entry informationi

Entry nameiD0IZV8_COMT2
AccessioniPrimary (citable) accession number: D0IZV8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: July 22, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.