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D0IZV8

- D0IZV8_COMT2

UniProt

D0IZV8 - D0IZV8_COMT2

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

CtCNB1_2815

Organism
Comamonas testosteroni (strain CNB-2)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysisUniRule annotation
    Metal bindingi352 – 3521Magnesium or manganese
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei550 – 5501SubstrateUniRule annotation
    Metal bindingi551 – 5511Magnesium or manganese
    Metal bindingi555 – 5551Magnesium or manganese

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciCTES543891:GJCV-2874-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported
    Gene namesi
    Ordered Locus Names:CtCNB1_2815Imported
    OrganismiComamonas testosteroni (strain CNB-2)Imported
    Taxonomic identifieri688245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeComamonas
    ProteomesiUP000002360: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi688245.CtCNB1_2815.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D0IZV8-1 [UniParc]FASTAAdd to Basket

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    MSTQQPTIIY TLTDEAPRLA TSAFLPVIRA FAAPAGINVE TSDISLAGRI    50
    LGEFPDFLTE AQRAPNNLAE LGKLTLTPEA NIIKLPNISA SVGQLQEAIK 100
    ELQGKGYAIP DYPETATTDA EKDIKARYNK CIGSAVNPVL REGNSDRRAP 150
    AAVKNYAKKH PHSMGEWKQW SQTHVSHMEE GDFYHGEKSM TLDKAREVKM 200
    VLETKSGNSI VLKDKVKLQA AEVIDSMFMS KKALCAFYEK EIEDCRESGI 250
    LFSLHVKATM MKVSHPIVFG HCVKIFYKEA FEKHGKLFDQ LGVNVNNGMA 300
    NLYEKIETLP ASQREEIIRD LHKCQEHRPR LAMVDSAKGI TNFHSPNDVI 350
    VDASMPAMIR VGGKMWAADG KPYDCKAVMP ESTFARIYQE VINFCKWHGN 400
    FDPKTMGTVP NVGLMAQKAE EYGSHDKTFE IAEDGVANIV DIATGEVLLS 450
    QNVEAGDIWR MCQVKDAPIR DWVKLAVTRA RNSGMPAVFW LDPYRPHEAE 500
    LIKKVQTYLK EYDTNGLEIH ILSQVRAMRY TLERVARGLD TISVTGNILR 550
    DYLTDLFPIL ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVQQLVEEN 600
    HLRWDSLGEF LALAVSFEDL GIKENNARAK LLAKTLDEAT GKLLDEDKSP 650
    SRRTGELDNR GSQFYIALYW AQALAAQTED AALAAKFAPL AKSLTENEAK 700
    IVAEMKEVQG KAADIGGYYM PDVAKLDAVM RPSATFNAAI ASV 743
    Length:743
    Mass (Da):82,151
    Last modified:December 15, 2009 - v1
    Checksum:i02ECB30F7886D652
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001220 Genomic DNA. Translation: ACY33561.1.
    RefSeqiYP_003278857.1. NC_013446.2.

    Genome annotation databases

    EnsemblBacteriaiACY33561; ACY33561; CtCNB1_2815.
    GeneIDi8562614.
    KEGGictt:CtCNB1_2815.
    PATRICi35266682. VBIComTes153857_2994.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001220 Genomic DNA. Translation: ACY33561.1 .
    RefSeqi YP_003278857.1. NC_013446.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 688245.CtCNB1_2815.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACY33561 ; ACY33561 ; CtCNB1_2815 .
    GeneIDi 8562614.
    KEGGi ctt:CtCNB1_2815.
    PATRICi 35266682. VBIComTes153857_2994.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci CTES543891:GJCV-2874-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome of Comamonas testosteroni reveals its genetic adaptations to changing environments."
      Ma Y.F., Zhang Y., Zhang J.Y., Chen D.W., Zhu Y., Zheng H., Wang S.Y., Jiang C.Y., Zhao G.P., Liu S.J.
      Appl. Environ. Microbiol. 75:6812-6819(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CNB-2Imported.

    Entry informationi

    Entry nameiD0IZV8_COMT2
    AccessioniPrimary (citable) accession number: D0IZV8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 15, 2009
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3