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D0IZV8

- D0IZV8_COMT2

UniProt

D0IZV8 - D0IZV8_COMT2

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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene
CtCNB1_2815
Organism
Comamonas testosteroni (strain CNB-2)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate By similarity
Sitei257 – 2571Critical for catalysis By similarityUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese By similarityUniRule annotation
Sitei422 – 4221Critical for catalysis By similarityUniRule annotation
Binding sitei550 – 5501Substrate By similarityUniRule annotation
Metal bindingi551 – 5511Magnesium or manganese By similarityUniRule annotation
Metal bindingi555 – 5551Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCTES543891:GJCV-2874-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported
Gene namesi
Ordered Locus Names:CtCNB1_2815Imported
OrganismiComamonas testosteroni (strain CNB-2)Imported
Taxonomic identifieri688245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeComamonas
ProteomesiUP000002360: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi688245.CtCNB1_2815.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarity

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

D0IZV8-1 [UniParc]FASTAAdd to Basket

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MSTQQPTIIY TLTDEAPRLA TSAFLPVIRA FAAPAGINVE TSDISLAGRI    50
LGEFPDFLTE AQRAPNNLAE LGKLTLTPEA NIIKLPNISA SVGQLQEAIK 100
ELQGKGYAIP DYPETATTDA EKDIKARYNK CIGSAVNPVL REGNSDRRAP 150
AAVKNYAKKH PHSMGEWKQW SQTHVSHMEE GDFYHGEKSM TLDKAREVKM 200
VLETKSGNSI VLKDKVKLQA AEVIDSMFMS KKALCAFYEK EIEDCRESGI 250
LFSLHVKATM MKVSHPIVFG HCVKIFYKEA FEKHGKLFDQ LGVNVNNGMA 300
NLYEKIETLP ASQREEIIRD LHKCQEHRPR LAMVDSAKGI TNFHSPNDVI 350
VDASMPAMIR VGGKMWAADG KPYDCKAVMP ESTFARIYQE VINFCKWHGN 400
FDPKTMGTVP NVGLMAQKAE EYGSHDKTFE IAEDGVANIV DIATGEVLLS 450
QNVEAGDIWR MCQVKDAPIR DWVKLAVTRA RNSGMPAVFW LDPYRPHEAE 500
LIKKVQTYLK EYDTNGLEIH ILSQVRAMRY TLERVARGLD TISVTGNILR 550
DYLTDLFPIL ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVQQLVEEN 600
HLRWDSLGEF LALAVSFEDL GIKENNARAK LLAKTLDEAT GKLLDEDKSP 650
SRRTGELDNR GSQFYIALYW AQALAAQTED AALAAKFAPL AKSLTENEAK 700
IVAEMKEVQG KAADIGGYYM PDVAKLDAVM RPSATFNAAI ASV 743
Length:743
Mass (Da):82,151
Last modified:December 15, 2009 - v1
Checksum:i02ECB30F7886D652
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001220 Genomic DNA. Translation: ACY33561.1.
RefSeqiYP_003278857.1. NC_013446.2.

Genome annotation databases

EnsemblBacteriaiACY33561; ACY33561; CtCNB1_2815.
GeneIDi8562614.
KEGGictt:CtCNB1_2815.
PATRICi35266682. VBIComTes153857_2994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001220 Genomic DNA. Translation: ACY33561.1 .
RefSeqi YP_003278857.1. NC_013446.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 688245.CtCNB1_2815.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACY33561 ; ACY33561 ; CtCNB1_2815 .
GeneIDi 8562614.
KEGGi ctt:CtCNB1_2815.
PATRICi 35266682. VBIComTes153857_2994.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci CTES543891:GJCV-2874-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome of Comamonas testosteroni reveals its genetic adaptations to changing environments."
    Ma Y.F., Zhang Y., Zhang J.Y., Chen D.W., Zhu Y., Zheng H., Wang S.Y., Jiang C.Y., Zhao G.P., Liu S.J.
    Appl. Environ. Microbiol. 75:6812-6819(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNB-2.

Entry informationi

Entry nameiD0IZV8_COMT2
AccessioniPrimary (citable) accession number: D0IZV8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: July 9, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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