D0IZV8 (D0IZV8_COMT2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase, NADP-dependent EMBL ACY33561.1

Gene names

Ordered Locus Names:

CtCNB1_2815

Organism

Comamonas testosteroni (strain CNB-2) [Complete proteome] [HAMAP]

Taxonomic identifier

688245 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Comamonas › Comamonas testosteroni › Comamonas testosteroni CNB-1

Protein attributes

Sequence length	743 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	134 – 141	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	352	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	551	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	555	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	147	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	550	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	257	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	422	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	D0IZV8 [UniParc]. Last modified December 15, 2009. Version 1. Checksum: 02ECB30F7886D652	FASTA	743	82,151
	10 20 30 40 50 60 MSTQQPTIIY TLTDEAPRLA TSAFLPVIRA FAAPAGINVE TSDISLAGRI LGEFPDFLTE 70 80 90 100 110 120 AQRAPNNLAE LGKLTLTPEA NIIKLPNISA SVGQLQEAIK ELQGKGYAIP DYPETATTDA 130 140 150 160 170 180 EKDIKARYNK CIGSAVNPVL REGNSDRRAP AAVKNYAKKH PHSMGEWKQW SQTHVSHMEE 190 200 210 220 230 240 GDFYHGEKSM TLDKAREVKM VLETKSGNSI VLKDKVKLQA AEVIDSMFMS KKALCAFYEK 250 260 270 280 290 300 EIEDCRESGI LFSLHVKATM MKVSHPIVFG HCVKIFYKEA FEKHGKLFDQ LGVNVNNGMA 310 320 330 340 350 360 NLYEKIETLP ASQREEIIRD LHKCQEHRPR LAMVDSAKGI TNFHSPNDVI VDASMPAMIR 370 380 390 400 410 420 VGGKMWAADG KPYDCKAVMP ESTFARIYQE VINFCKWHGN FDPKTMGTVP NVGLMAQKAE 430 440 450 460 470 480 EYGSHDKTFE IAEDGVANIV DIATGEVLLS QNVEAGDIWR MCQVKDAPIR DWVKLAVTRA 490 500 510 520 530 540 RNSGMPAVFW LDPYRPHEAE LIKKVQTYLK EYDTNGLEIH ILSQVRAMRY TLERVARGLD 550 560 570 580 590 600 TISVTGNILR DYLTDLFPIL ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVQQLVEEN 610 620 630 640 650 660 HLRWDSLGEF LALAVSFEDL GIKENNARAK LLAKTLDEAT GKLLDEDKSP SRRTGELDNR 670 680 690 700 710 720 GSQFYIALYW AQALAAQTED AALAAKFAPL AKSLTENEAK IVAEMKEVQG KAADIGGYYM 730 740 PDVAKLDAVM RPSATFNAAI ASV

References

[1]

"The complete genome of Comamonas testosteroni reveals its genetic adaptations to changing environments." Ma Y.F., Zhang Y., Zhang J.Y., Chen D.W., Zhu Y., Zheng H., Wang S.Y., Jiang C.Y., Zhao G.P., Liu S.J. Appl. Environ. Microbiol. 75:6812-6819(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CNB-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001220 Genomic DNA. Translation: ACY33561.1.
RefSeq	YP_003278857.1. NC_013446.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	688245.CtCNB1_2815.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACY33561; ACY33561; CtCNB1_2815.
GeneID	8562614.
KEGG	ctt:CtCNB1_2815.
PATRIC	35266682. VBIComTes153857_2994.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2838.
HOGENOM	HOG000240860.
KO	K00031.
Enzyme and pathway databases
BioCyc	CTES543891:GJCV-2874-MONOMER.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D0IZV8_COMT2

Accession

Primary (citable) accession number: D0IZV8

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2009
Last sequence update:	December 15, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)