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D0IWC0

- D0IWC0_COMT2

UniProt

D0IWC0 - D0IWC0_COMT2

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Protein

Alanine racemase

Gene

CtCNB1_0192

Organism
Comamonas testosteroni (strain CNB-2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei130 – 1301SubstrateUniRule annotation
Active sitei256 – 2561Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei304 – 3041Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCTES543891:GJCV-193-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:CtCNB1_0192Imported
OrganismiComamonas testosteroni (strain CNB-2)Imported
Taxonomic identifieri688245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeComamonas
ProteomesiUP000002360: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi688245.CtCNB1_0192.

Structurei

3D structure databases

ProteinModelPortaliD0IWC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031446.
KOiK01775.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0IWC0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRPITATIH PEAVRHNLER VRQAVPDAKL WSVIKANAYG HGIENVFEGL
60 70 80 90 100
RATDGFAMLD LDEAQRVRNL GWRGPILLLE GVFELRDLEI CSRLGIWHAV
110 120 130 140 150
HCDEQIDWLA AHKTQVGHRV FLKMNSGMNR LGFTPERFRA AYARLNALPQ
160 170 180 190 200
VDEISFMTHF SDADVEHGLD HQLRVFHETT LDLPGERSVS NSAATLLHGD
210 220 230 240 250
ENNVRCDWVR PGIVLYGSSP DFPTHDAAHW GLEPTMTLSS KIIGTQELHA
260 270 280 290 300
GDTVGYGSRF QCDGPLRLGV VACGYADGYP RVCPTGTPVL VDGVRTRTLG
310 320 330 340 350
RVSMDMMAVD LSPVPKARLG SEVTLWGRAS NGAVLPIDEV AAAAGTLGYE
360
LMCAVAPRVP KQVEGAGK
Length:368
Mass (Da):40,295
Last modified:December 15, 2009 - v1
Checksum:i7DD1D5B92559F268
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001220 Genomic DNA. Translation: ACY30938.1.
RefSeqiWP_003070517.1. NC_013446.2.
YP_003276234.1. NC_013446.2.

Genome annotation databases

EnsemblBacteriaiACY30938; ACY30938; CtCNB1_0192.
GeneIDi8565338.
KEGGictt:CtCNB1_0192.
PATRICi35261173. VBIComTes153857_0298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001220 Genomic DNA. Translation: ACY30938.1 .
RefSeqi WP_003070517.1. NC_013446.2.
YP_003276234.1. NC_013446.2.

3D structure databases

ProteinModelPortali D0IWC0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 688245.CtCNB1_0192.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACY30938 ; ACY30938 ; CtCNB1_0192 .
GeneIDi 8565338.
KEGGi ctt:CtCNB1_0192.
PATRICi 35261173. VBIComTes153857_0298.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031446.
KOi K01775.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CTES543891:GJCV-193-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome of Comamonas testosteroni reveals its genetic adaptations to changing environments."
    Ma Y.F., Zhang Y., Zhang J.Y., Chen D.W., Zhu Y., Zheng H., Wang S.Y., Jiang C.Y., Zhao G.P., Liu S.J.
    Appl. Environ. Microbiol. 75:6812-6819(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNB-2Imported.

Entry informationi

Entry nameiD0IWC0_COMT2
AccessioniPrimary (citable) accession number: D0IWC0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3