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D0IWC0

- D0IWC0_COMT2

UniProt

D0IWC0 - D0IWC0_COMT2

Protein

Alanine racemase

Gene

CtCNB1_0192

Organism
Comamonas testosteroni (strain CNB-2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei130 – 1301SubstrateUniRule annotation
    Active sitei256 – 2561Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei304 – 3041Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCTES543891:GJCV-193-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:CtCNB1_0192Imported
    OrganismiComamonas testosteroni (strain CNB-2)Imported
    Taxonomic identifieri688245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeComamonas
    ProteomesiUP000002360: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi688245.CtCNB1_0192.

    Structurei

    3D structure databases

    ProteinModelPortaliD0IWC0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031446.
    KOiK01775.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D0IWC0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRPITATIH PEAVRHNLER VRQAVPDAKL WSVIKANAYG HGIENVFEGL    50
    RATDGFAMLD LDEAQRVRNL GWRGPILLLE GVFELRDLEI CSRLGIWHAV 100
    HCDEQIDWLA AHKTQVGHRV FLKMNSGMNR LGFTPERFRA AYARLNALPQ 150
    VDEISFMTHF SDADVEHGLD HQLRVFHETT LDLPGERSVS NSAATLLHGD 200
    ENNVRCDWVR PGIVLYGSSP DFPTHDAAHW GLEPTMTLSS KIIGTQELHA 250
    GDTVGYGSRF QCDGPLRLGV VACGYADGYP RVCPTGTPVL VDGVRTRTLG 300
    RVSMDMMAVD LSPVPKARLG SEVTLWGRAS NGAVLPIDEV AAAAGTLGYE 350
    LMCAVAPRVP KQVEGAGK 368
    Length:368
    Mass (Da):40,295
    Last modified:December 15, 2009 - v1
    Checksum:i7DD1D5B92559F268
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001220 Genomic DNA. Translation: ACY30938.1.
    RefSeqiWP_003070517.1. NC_013446.2.
    YP_003276234.1. NC_013446.2.

    Genome annotation databases

    EnsemblBacteriaiACY30938; ACY30938; CtCNB1_0192.
    GeneIDi8565338.
    KEGGictt:CtCNB1_0192.
    PATRICi35261173. VBIComTes153857_0298.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001220 Genomic DNA. Translation: ACY30938.1 .
    RefSeqi WP_003070517.1. NC_013446.2.
    YP_003276234.1. NC_013446.2.

    3D structure databases

    ProteinModelPortali D0IWC0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 688245.CtCNB1_0192.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACY30938 ; ACY30938 ; CtCNB1_0192 .
    GeneIDi 8565338.
    KEGGi ctt:CtCNB1_0192.
    PATRICi 35261173. VBIComTes153857_0298.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031446.
    KOi K01775.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci CTES543891:GJCV-193-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome of Comamonas testosteroni reveals its genetic adaptations to changing environments."
      Ma Y.F., Zhang Y., Zhang J.Y., Chen D.W., Zhu Y., Zheng H., Wang S.Y., Jiang C.Y., Zhao G.P., Liu S.J.
      Appl. Environ. Microbiol. 75:6812-6819(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CNB-2Imported.

    Entry informationi

    Entry nameiD0IWC0_COMT2
    AccessioniPrimary (citable) accession number: D0IWC0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 15, 2009
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3