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D0IWC0 (D0IWC0_COMT2) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 SAAS SAAS020622

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS020622

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site351Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2561Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1301Substrate By similarity HAMAP-Rule MF_01201
Binding site3041Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue351N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
D0IWC0 [UniParc].

Last modified December 15, 2009. Version 1.
Checksum: 7DD1D5B92559F268

FASTA36840,295
        10         20         30         40         50         60 
MPRPITATIH PEAVRHNLER VRQAVPDAKL WSVIKANAYG HGIENVFEGL RATDGFAMLD 

        70         80         90        100        110        120 
LDEAQRVRNL GWRGPILLLE GVFELRDLEI CSRLGIWHAV HCDEQIDWLA AHKTQVGHRV 

       130        140        150        160        170        180 
FLKMNSGMNR LGFTPERFRA AYARLNALPQ VDEISFMTHF SDADVEHGLD HQLRVFHETT 

       190        200        210        220        230        240 
LDLPGERSVS NSAATLLHGD ENNVRCDWVR PGIVLYGSSP DFPTHDAAHW GLEPTMTLSS 

       250        260        270        280        290        300 
KIIGTQELHA GDTVGYGSRF QCDGPLRLGV VACGYADGYP RVCPTGTPVL VDGVRTRTLG 

       310        320        330        340        350        360 
RVSMDMMAVD LSPVPKARLG SEVTLWGRAS NGAVLPIDEV AAAAGTLGYE LMCAVAPRVP 


KQVEGAGK 

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References

[1]"The complete genome of Comamonas testosteroni reveals its genetic adaptations to changing environments."
Ma Y.F., Zhang Y., Zhang J.Y., Chen D.W., Zhu Y., Zheng H., Wang S.Y., Jiang C.Y., Zhao G.P., Liu S.J.
Appl. Environ. Microbiol. 75:6812-6819(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CNB-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001220 Genomic DNA. Translation: ACY30938.1.
RefSeqYP_003276234.1. NC_013446.2.

3D structure databases

ProteinModelPortalD0IWC0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING688245.CtCNB1_0192.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACY30938; ACY30938; CtCNB1_0192.
GeneID8565338.
KEGGctt:CtCNB1_0192.
PATRIC35261173. VBIComTes153857_0298.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031446.
KOK01775.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

BioCycCTES543891:GJCV-193-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD0IWC0_COMT2
AccessionPrimary (citable) accession number: D0IWC0
Entry history
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: July 9, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)