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Protein

Thymidine kinase

Gene

tdk

Organism
Leptotrichia goodfellowii F0264
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93Proton acceptorUniRule annotation1
Metal bindingi149ZincUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Metal bindingi187ZincUniRule annotation1
Metal bindingi190ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 24ATPUniRule annotation8
Nucleotide bindingi92 – 95ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:HMPREF0554_2049Imported
OrganismiLeptotrichia goodfellowii F0264Imported
Taxonomic identifieri596323 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesLeptotrichiaceaeLeptotrichia
Proteomesi
  • UP000004226 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi596323.HMPREF0554_2049

Structurei

3D structure databases

ProteinModelPortaliD0GKH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili237 – 264Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4107UGU Bacteria
COG1435 LUCA
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

D0GKH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFHLKSNMG TLEVVTGSMF SGKSEELIRR LRRAKYAKQK VIVFKHAIDN
60 70 80 90 100
RYGEKGIFSH GNDSLEAYPA SSTEQMEEIM VKNNDAEVIG IDEVQFFGQS
110 120 130 140 150
VVDFCKKYVE YGKRVIVAGL DMSFRAEPYH PMPELMGIAD QVDKLHAICT
160 170 180 190 200
VCGKPAYASQ RLIDGEPAYY DDPLVMVGAS ENYEARCRRH HIVKYRENKM
210 220 230 240 250
GKIYFMVGTD IGVGKKSVEK LYSKNILKDK KTKTVVITSG IEKYENNENK
260 270 280 290 300
LSELREEIEK ELMRNDFVFV RIVRGLLLPI EGNYNVLDFM CEYRKNSEII
310 320 330 340 350
LVSQNKKGVL NQVLLTVDLL RKSDLNFREI VYTNKNVIDK ENIEIIEKIK
360
EITKLDYRII D
Length:361
Mass (Da):41,630
Last modified:December 15, 2009 - v1
Checksum:i18AAF01FE980C2FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADAD01000082 Genomic DNA Translation: EEY35375.1
RefSeqiWP_006806978.1, NZ_ADAD01000082.1

Genome annotation databases

EnsemblBacteriaiEEY35375; EEY35375; HMPREF0554_2049

Similar proteinsi

Entry informationi

Entry nameiD0GKH7_9FUSO
AccessioniPrimary (citable) accession number: D0GKH7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: March 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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