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Protein

Angiotensin-converting enzyme-like protein Ace3

Gene

Ace3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Protein family/group databases

MEROPSiM02.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzyme-like protein Ace3Curated
Gene namesi
Name:Ace3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3644400. Ace3.

Subcellular locationi

  • Cytoplasmic vesiclesecretory vesicleacrosome membrane 1 Publication; Multi-pass membrane protein Sequence analysis

  • Note: Disappears from acrosome reacted sperm. Co-localizes with IZUMO1 at acrosomal cap area.1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 639ExtracellularCuratedAdd BLAST616
Transmembranei640 – 660HelicalSequence analysisAdd BLAST21
Topological domaini661 – 700CytoplasmicCuratedAdd BLAST40
Transmembranei701 – 721HelicalSequence analysisAdd BLAST21
Topological domaini722 – 737ExtracellularCuratedAdd BLAST16

GO - Cellular componenti

  • acrosomal vesicle Source: MGI
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Sperm have normal fertilizing ability.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500895218224 – 737Angiotensin-converting enzyme-like protein Ace3Add BLAST714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiD0G895.

Expressioni

Tissue specificityi

Expressed in sperm and testis (at protein level) (PubMed:20421979). Expressed in heart and testis (PubMed:17597519). Not detected in kidney, lung, liver, brain, ovary, spleen and thymus (PubMed:17597519, PubMed:20421979).2 Publications

Interactioni

Subunit structurei

Interacts with IZUMO1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137762.

Structurei

3D structure databases

SMRiD0G895.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3690. Eukaryota.
ENOG410XPJ3. LUCA.
GeneTreeiENSGT00520000055576.
KOiK01283.
OMAiGPCLPLE.
OrthoDBiEOG091G033S.

Family and domain databases

CDDicd06461. M2_ACE. 1 hit.
InterProiView protein in InterPro
IPR001548. Peptidase_M2.
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiView protein in Pfam
PF01401. Peptidase_M2. 1 hit.
PRINTSiPR00791. PEPDIPTASEA.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D0G895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLPWALLLV LLSHRQLLPW LRTVGETSLN DFYSEAQAKL FLQFYEQTAQ
60 70 80 90 100
VVLNEFMEAT WNYVTNITKQ NQKNMLQKEA DRSQFMLYFS TRARMFRTDH
110 120 130 140 150
FLNQDVKRML RKLQNIDKSA LPTEDLLEYN RLLTYMETAY NRAEVCLDEG
160 170 180 190 200
PCLTLEPDLQ EIMATSRDQK ELLWAWQGWR DAVGRQLRPV FEDYVRLSNK
210 220 230 240 250
AAQYNGYKDM GALWRSKYES DTLEEDLEQL YKELQPLYLN LHAYVRRSLY
260 270 280 290 300
RYYGPELIDL RGPIPAHLLG NMWAQSWNNI LDLVLPYPTK APEDITAIMK
310 320 330 340 350
IQHWRPEKMF EEANLFFTSM GMLPAPPAFW IKSMMEKPAD GREVECHTSS
360 370 380 390 400
WNFYKFNDFR VKKCTEVTLE DLLSVFHQMG HIQYFLQYQN LSVIYQEGAS
410 420 430 440 450
PAFEEAVGSV IALSVSSHKY LLARGLLSQP HQDSEEEVNF LLGIALEKIA
460 470 480 490 500
FIPFSYLVDK FRWKIFDGTI SKITYNQEWW NFRLKYQGLC PPVPRSDDDF
510 520 530 540 550
DPGAKFHIPA NVPYIRYFLG LILQFQLHEA LCEASGHVGP LHQCDNYNSK
560 570 580 590 600
VAGKILGDLL KLGSSRPWRE VLQEVTGESN ISTKAFLTYF KPLMDWLVTE
610 620 630 640 650
NVKQGDTLGW PDFSCSFEEK ITSKVSFLGT DTEPEQAYLG QWVLLSMSFF
660 670 680 690 700
MLVLILALGF RLHYLEKQLL DEDTMILKTL PYSYFLGIAM EPHQAARKQW
710 720 730
LLLGLCCILM LCCIGLLIRI VTQNTENTPW MKNEGQS
Length:737
Mass (Da):85,874
Last modified:December 15, 2009 - v1
Checksum:i149363A9C6372A61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB531024 mRNA. Translation: BAI48788.1.
AL596331 Genomic DNA. No translation available.
RefSeqiNP_001094923.2. NM_001101453.2.
UniGeneiMm.296699.

Genome annotation databases

EnsembliENSMUST00000190995; ENSMUSP00000140827; ENSMUSG00000101605.
GeneIDi217246.
KEGGimmu:217246.
UCSCiuc011ygg.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACE3_MOUSE
AccessioniPrimary (citable) accession number: D0G895
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2017
Last sequence update: December 15, 2009
Last modified: June 7, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks the conserved Glu residue in position 378 necessary for the catalytic activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families