ID   D0EYG7_HUMAN            Unreviewed;       152 AA.
AC   D0EYG7;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Interleukin-7 {ECO:0000256|ARBA:ARBA00019460};
DE   Flags: Fragment;
GN   Name=IL7 {ECO:0000313|EMBL:ACX53627.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACX53627.1};
RN   [1] {ECO:0000313|EMBL:ACX53627.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Geng M., Zhang Y.-T., Chen Q., Wang F.-P., Xu L.-H., Ouyang D.-Y.,
RA   He X.-H.;
RT   "Purification and characterization of human interleukin-7 expressed in
RT   Escherichia coli.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ANQ68335.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=27342246;
RA   Devi N., Adivitiya, Khasa Y.P.;
RT   "A combinatorial approach of N-terminus blocking and codon optimization
RT   strategies to enhance the soluble expression of recombinant hIL-7 in E.
RT   coli fed-batch culture.";
RL   Appl. Microbiol. Biotechnol. 0:0-0(2016).
CC   -!- SUBUNIT: Interacts with IL7R and CSF2RG.
CC       {ECO:0000256|ARBA:ARBA00034136}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the IL-7/IL-9 family.
CC       {ECO:0000256|ARBA:ARBA00007621}.
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DR   EMBL; GQ919059; ACX53627.1; -; mRNA.
DR   EMBL; KX160446; ANQ68335.1; -; mRNA.
DR   AlphaFoldDB; D0EYG7; -.
DR   SMR; D0EYG7; -.
DR   PeptideAtlas; D0EYG7; -.
DR   ChiTaRS; IL7; human.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   GO; GO:0005139; F:interleukin-7 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 1.20.1250.50; -; 1.
DR   InterPro; IPR001181; IL-7.
DR   InterPro; IPR018049; IL-7/IL-9_CS.
DR   InterPro; IPR038325; IL7_sf.
DR   PANTHER; PTHR48404; INTERLEUKIN-7; 1.
DR   PANTHER; PTHR48404:SF1; INTERLEUKIN-7; 1.
DR   Pfam; PF01415; IL7; 1.
DR   PIRSF; PIRSF001942; IL-7; 1.
DR   PRINTS; PR00435; INTERLEUKIN7.
DR   SMART; SM00127; IL7; 1.
DR   PROSITE; PS00255; INTERLEUKIN_7_9; 1.
PE   2: Evidence at transcript level;
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR001942-1};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DISULFID        2..141
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001942-1"
FT   DISULFID        34..129
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001942-1"
FT   DISULFID        47..92
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001942-1"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACX53627.1"
SQ   SEQUENCE   152 AA;  17387 MW;  DCA15D4A22628F01 CRC64;
     DCDIEGKDGK QYESVLMVSI DQLLDSMKEI GSNCLNNEFN FFKRHICDAN KEGMFLFRAA
     RKLRQFLKMN STGDFDLHLL KVSEGTTILL NCTGQVKGRK PAALGEAQPT KSLEENKSLK
     EQKKLNDLCF LKRLLQEIKT CWNKILMGTK EH
//