ID   D0EY27_MOUSE            Unreviewed;       109 AA.
AC   D0EY27;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   RecName: Full=Insulin {ECO:0000256|RuleBase:RU000406};
DE   Flags: Fragment;
GN   Name=Ins2 {ECO:0000313|EMBL:ACX53313.1, ECO:0000313|MGI:MGI:96573};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:ACX53313.1};
RN   [1] {ECO:0000313|EMBL:ACX53313.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/c {ECO:0000313|EMBL:ACX53313.1};
RA   Panda A., Seshadri V.;
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver. {ECO:0000256|ARBA:ARBA00002985,
CC       ECO:0000256|RuleBase:RU000406}.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds. {ECO:0000256|RuleBase:RU000406}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU000406}.
CC   -!- SIMILARITY: Belongs to the insulin family.
CC       {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR   EMBL; GQ915612; ACX53313.1; -; mRNA.
DR   AlphaFoldDB; D0EY27; -.
DR   SMR; D0EY27; -.
DR   AGR; MGI:96573; -.
DR   MGI; MGI:96573; Ins2.
DR   OMA; CENTCSL; -.
DR   ChiTaRS; Ins2; mouse.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   Gene3D; 1.10.100.10; Insulin-like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454:SF33; INSULIN-2; 1.
DR   PANTHER; PTHR11454; INSULIN/INSULIN GROWTH FACTOR; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; Insulin-like; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277,
KW   ECO:0000256|RuleBase:RU000406};
KW   Glucose metabolism {ECO:0000256|ARBA:ARBA00022526,
KW   ECO:0000256|RuleBase:RU000406};
KW   Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU000406};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..109
FT                   /note="Insulin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003008224"
FT   DOMAIN          28..109
FT                   /note="Insulin-like"
FT                   /evidence="ECO:0000259|SMART:SM00078"
FT   NON_TER         109
FT                   /evidence="ECO:0000313|EMBL:ACX53313.1"
SQ   SEQUENCE   109 AA;  12250 MW;  34C8803D24FDAD6C CRC64;
     MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY TPMSRREVED
     PQVAQLELGG GPGAGDLQTL ALEVAQQKRG IVDQCCTSIC SLYQLENYC
//