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D0EY27 (D0EY27_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 14, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Ins2 EMBL ACX53313.1 MGI 96573
OrganismMus musculus (Mouse) EMBL ACX53313.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length109 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver By similarity. SAAS SAAS004825

Subunit structure

Heterodimer of a B chain and an A chain linked by two disulfide bonds By similarity. SAAS SAAS004825

Subcellular location

Secreted By similarity RuleBase RU000406 SAAS SAAS004825.

Sequence similarities

Belongs to the insulin family. RuleBase RU000406

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism SAAS SAAS004825
   Cellular componentSecreted SAAS SAAS004825
   Molecular functionHormone SAAS SAAS004825
   PTMDisulfide bond SAAS SAAS004825
Gene Ontology (GO)
   Biological_processER overload response

Inferred from mutant phenotype PubMed 11854325. Source: MGI

activation of MAPK activity

Inferred from direct assay PubMed 12059784. Source: MGI

canonical Wnt signaling pathway

Inferred from genetic interaction PubMed 15282335. Source: MGI

glucose metabolic process

Inferred from mutant phenotype PubMed 11854325. Source: MGI

glucose transport

Traceable author statement PubMed 12297296. Source: MGI

insulin receptor signaling pathway

Inferred from direct assay PubMed 12805218. Source: MGI

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Inferred from mutant phenotype PubMed 11854325. Source: MGI

lipid catabolic process

Inferred from direct assay PubMed 12805218. Source: MGI

myoblast fusion

Inferred from genetic interaction PubMed 15282335. Source: MGI

myotube differentiation

Inferred from genetic interaction PubMed 15282335. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 9689059. Source: MGI

positive regulation of phosphatidylinositol 3-kinase activity

Inferred from direct assay PubMed 11375348. Source: MGI

regulation of gene expression

Inferred from direct assay PubMed 19293336. Source: MGI

regulation of phosphorylation

Inferred from direct assay PubMed 12059784. Source: MGI

regulation of protein binding

Inferred from direct assay PubMed 9507006. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15793245. Source: MGI

extracellular space

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 12488434. Source: MGI

secretory granule

Inferred from direct assay PubMed 15788565. Source: MGI

small nucleolar ribonucleoprotein complex

Inferred from direct assay PubMed 12488434. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue1091 EMBL ACX53313.1

Sequences

Sequence LengthMass (Da)Tools
D0EY27 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 34C8803D24FDAD6C

FASTA10912,250
        10         20         30         40         50         60 
MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY TPMSRREVED 

        70         80         90        100 
PQVAQLELGG GPGAGDLQTL ALEVAQQKRG IVDQCCTSIC SLYQLENYC 

« Hide

References

[1]Panda A., Seshadri V.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/c EMBL ACX53313.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GQ915612 mRNA. Translation: ACX53313.1.
UniGeneMm.4946.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:96573. Ins2.

Phylogenomic databases

OMAVEQCCHN.

Gene expression databases

ArrayExpressD0EY27.
BgeeD0EY27.

Family and domain databases

Gene3D1.10.100.10. 1 hit.
InterProIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 1 hit.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIns2. mouse.
NextBio35548362.
SOURCESearch...

Entry information

Entry nameD0EY27_MOUSE
AccessionPrimary (citable) accession number: D0EY27
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)