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D0EY27

- D0EY27_MOUSE

UniProt

D0EY27 - D0EY27_MOUSE

Protein
Submitted name:

Insulin-2

Gene

Ins2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SAAS annotation

    GO - Biological processi

    1. activation of MAPK activity Source: MGI
    2. canonical Wnt signaling pathway Source: MGI
    3. ER overload response Source: MGI
    4. glucose metabolic process Source: MGI
    5. glucose transport Source: MGI
    6. insulin receptor signaling pathway Source: MGI
    7. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI
    8. lipid catabolic process Source: MGI
    9. myoblast fusion Source: MGI
    10. myotube differentiation Source: MGI
    11. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    12. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
    13. regulation of gene expression Source: MGI
    14. regulation of phosphorylation Source: MGI
    15. regulation of protein binding Source: MGI

    Keywords - Molecular functioni

    HormoneSAAS annotation

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolismSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Insulin-2Imported
    Gene namesi
    Name:Ins2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:96573. Ins2.

    Subcellular locationi

    Secreted UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular space Source: Ensembl
    3. nucleus Source: MGI
    4. secretory granule Source: MGI
    5. small nucleolar ribonucleoprotein complex Source: MGI

    Keywords - Cellular componenti

    SecretedSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiD0EY27.
    BgeeiD0EY27.

    Interactioni

    Subunit structurei

    Heterodimer of a B chain and an A chain linked by two disulfide bonds.SAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the insulin family.UniRule annotation

    Phylogenomic databases

    OMAiVEQCCHN.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR004825. Insulin.
    IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR00277. INSULIN.
    PR00276. INSULINFAMLY.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    D0EY27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY    50
    TPMSRREVED PQVAQLELGG GPGAGDLQTL ALEVAQQKRG IVDQCCTSIC 100
    SLYQLENYC 109
    Length:109
    Mass (Da):12,250
    Last modified:November 24, 2009 - v1
    Checksum:i34C8803D24FDAD6C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei109 – 1091Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ915612 mRNA. Translation: ACX53313.1.
    UniGeneiMm.4946.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ915612 mRNA. Translation: ACX53313.1 .
    UniGenei Mm.4946.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:96573. Ins2.

    Phylogenomic databases

    OMAi VEQCCHN.

    Miscellaneous databases

    ChiTaRSi Ins2. mouse.
    NextBioi 35548362.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi D0EY27.
    Bgeei D0EY27.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR004825. Insulin.
    IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR00277. INSULIN.
    PR00276. INSULINFAMLY.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Panda A., Seshadri V.
      Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/cImported.

    Entry informationi

    Entry nameiD0EY27_MOUSE
    AccessioniPrimary (citable) accession number: D0EY27
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 24, 2009
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)