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D0EY27

- D0EY27_MOUSE

UniProt

D0EY27 - D0EY27_MOUSE

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Protein
Submitted name:

Insulin-2

Gene

Ins2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SAAS annotation

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. canonical Wnt signaling pathway Source: MGI
  3. ER overload response Source: MGI
  4. glucose metabolic process Source: MGI
  5. glucose transport Source: MGI
  6. insulin receptor signaling pathway Source: MGI
  7. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI
  8. lipid catabolic process Source: MGI
  9. myoblast fusion Source: MGI
  10. myotube differentiation Source: MGI
  11. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  12. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  13. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
  14. regulation of gene expression Source: MGI
  15. regulation of phosphorylation Source: MGI
  16. regulation of protein binding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HormoneSAAS annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-2Imported
Gene namesi
Name:Ins2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96573. Ins2.

Subcellular locationi

Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular space Source: Ensembl
  3. nucleus Source: MGI
  4. secretory granule Source: MGI
  5. small nucleolar ribonucleoprotein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiD0EY27.
ExpressionAtlasiD0EY27. baseline and differential.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.SAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.UniRule annotation

Phylogenomic databases

OMAiVEQCCHN.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D0EY27-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPMSRREVED PQVAQLELGG GPGAGDLQTL ALEVAQQKRG IVDQCCTSIC

SLYQLENYC
Length:109
Mass (Da):12,250
Last modified:November 24, 2009 - v1
Checksum:i34C8803D24FDAD6C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei109 – 1091Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ915612 mRNA. Translation: ACX53313.1.
UniGeneiMm.4946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ915612 mRNA. Translation: ACX53313.1 .
UniGenei Mm.4946.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:96573. Ins2.

Phylogenomic databases

OMAi VEQCCHN.

Miscellaneous databases

ChiTaRSi Ins2. mouse.
NextBioi 35548362.
SOURCEi Search...

Gene expression databases

Bgeei D0EY27.
ExpressionAtlasi D0EY27. baseline and differential.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF00049. Insulin. 1 hit.
[Graphical view ]
PRINTSi PR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Panda A., Seshadri V.
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cImported.

Entry informationi

Entry nameiD0EY27_MOUSE
AccessioniPrimary (citable) accession number: D0EY27
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: November 26, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)