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Protein

Toll-like receptor 4

Gene

TLR-4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Immunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 4UniRule annotation
Gene namesi
Name:TLR-4Imported
Synonyms:TLR4UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cell membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiD0EWT7.

Interactioni

Subunit structurei

Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000363089.

Family & Domainsi

Sequence similaritiesi

Belongs to the Toll-like receptor family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000037951.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR027168. TLR4.
[Graphical view]
PANTHERiPTHR24365:SF230. PTHR24365:SF230. 2 hits.
SUPFAMiSSF52058. SSF52058. 1 hit.

Sequencei

Sequence statusi: Fragment.

D0EWT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RNEGNLEKFD KSALEGLCNL TIEEFRLAYL DYYLDDIIDL FNCLTNVSSF
60 70 80 90 100
SLVSVTIERV KDFSYNFGWQ HLELVNCKFG QFPTLKLKSL KRLTFTSNKG
110 120 130 140 150
GNAFSEVDLP SLEFLDLSRN GLSFKGCCSQ SDFGTTSLKY LDLSFNGVIT
160
MSSNFLGLEQ LEHLDFQHS
Length:169
Mass (Da):19,220
Last modified:November 24, 2009 - v1
Checksum:iDA600711F8AB479A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei169 – 1691Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ903698 Genomic DNA. Translation: ACX46980.1.
GQ903701 Genomic DNA. Translation: ACX46983.1.
GQ903702 Genomic DNA. Translation: ACX46984.1.
UniGeneiHs.174312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ903698 Genomic DNA. Translation: ACX46980.1.
GQ903701 Genomic DNA. Translation: ACX46983.1.
GQ903702 Genomic DNA. Translation: ACX46984.1.
UniGeneiHs.174312.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363089.

Proteomic databases

PeptideAtlasiD0EWT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000037951.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR027168. TLR4.
[Graphical view]
PANTHERiPTHR24365:SF230. PTHR24365:SF230. 2 hits.
SUPFAMiSSF52058. SSF52058. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Quantitative and functional evaluation of innate immune responses in patients with common variable immunodeficiency."
    Trujillo-Vargas C.M., Muskus C.E., Arango J.C., Patino P.J., Montoya C.J.
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AMC-CVIDImported, DAI-HIESImported and MDR-HCImported.

Entry informationi

Entry nameiD0EWT7_HUMAN
AccessioniPrimary (citable) accession number: D0EWT7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: July 6, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.