ID   D0ESZ5_MOUSE            Unreviewed;       393 AA.
AC   D0ESZ5;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   24-JAN-2024, entry version 69.
DE   RecName: Full=Plasminogen activator inhibitor 1 {ECO:0000256|ARBA:ARBA00040523};
DE   AltName: Full=Endothelial plasminogen activator inhibitor {ECO:0000256|ARBA:ARBA00041825};
DE   AltName: Full=Serpin E1 {ECO:0000256|ARBA:ARBA00043166};
DE   Flags: Fragment;
GN   Name=Serpine1 {ECO:0000313|EMBL:ACX48997.1,
GN   ECO:0000313|MGI:MGI:97608};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:ACX48997.1};
RN   [1] {ECO:0000313|EMBL:ACX48997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:ACX48997.1};
RA   Sa Q., Hoover-Plow J.;
RT   "Polymorphisms in PAI-1 in A/J and C57BL/6J mice.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|ARBA:ARBA00009500, ECO:0000256|RuleBase:RU000411}.
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DR   EMBL; GQ872458; ACX48997.1; -; mRNA.
DR   AlphaFoldDB; D0ESZ5; -.
DR   MEROPS; I04.020; -.
DR   PeptideAtlas; D0ESZ5; -.
DR   AGR; MGI:97608; -.
DR   MGI; MGI:97608; Serpine1.
DR   ChiTaRS; Serpine1; mouse.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR   Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461:SF49; PLASMINOGEN ACTIVATOR INHIBITOR 1; 1.
DR   PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; Serpins; 1.
PE   2: Evidence at transcript level;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..393
FT                   /note="Plasminogen activator inhibitor 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003007717"
FT   DOMAIN          40..393
FT                   /note="Serpin"
FT                   /evidence="ECO:0000259|SMART:SM00093"
FT   NON_TER         393
FT                   /evidence="ECO:0000313|EMBL:ACX48997.1"
SQ   SEQUENCE   393 AA;  44011 MW;  DC6A1728DA2A745D CRC64;
     MQMSSALACL ILGLVLVSGK GFTLPLRESH TAHQATDFGV KVFQQVVQAS KDRNVVFSPY
     GVSSVLAMLQ MTTAGKTRRQ IQDAMGFKVN EKGTAHALRQ LSKELMGPWN KNEISTADAI
     FVQRDLELVQ GFMPHFFKLF QTMVKQVDFS EVERARFIIN DWVERHTKGM ISDLLAKGAV
     DELTRLVLVN ALYFSGQWKT PFLEASTHQR LFHKSDGSTV SVPMMAQSNK FNYTEFTTPD
     GLEYDVVELP YQGDTLSMFI AAPFEKDVHL SALTNILDAE LIRQWKGNMT RLPRLLILPK
     FSLETEVDLR GPLEKLGMPD MFSATLADFT SLSDQEQLSV AQALQKVRIE VNESGTVASS
     STAFVISARM APTEMVIDRS FLFVVRHNPT ETI
//