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D0ESZ5 (D0ESZ5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Serpine1 EMBL ACX48997.1 MGI 97608
OrganismMus musculus (Mouse) EMBL ACX48997.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length393 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the serpin family. RuleBase RU000411

Ontologies

Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

chronological cell aging

Inferred from electronic annotation. Source: Ensembl

defense response to Gram-negative bacterium

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell adhesion mediated by integrin

Inferred from electronic annotation. Source: Ensembl

negative regulation of endothelial cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Inferred from electronic annotation. Source: Ensembl

negative regulation of fibrinolysis

Inferred from electronic annotation. Source: Ensembl

negative regulation of plasminogen activation

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

negative regulation of vascular wound healing

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-8 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of leukotriene production involved in inflammatory response

Inferred from electronic annotation. Source: Ensembl

positive regulation of monocyte chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of receptor-mediated endocytosis

Inferred from electronic annotation. Source: Ensembl

regulation of angiogenesis

Inferred from direct assay PubMed 11818362. Source: MGI

regulation of cell proliferation

Inferred from genetic interaction PubMed 18258607. Source: MGI

regulation of receptor activity

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular matrix

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 15328353PubMed 8939962. Source: MGI

serine-type endopeptidase inhibitor activity

Inferred from direct assay PubMed 15328353. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue3931 EMBL ACX48997.1

Sequences

Sequence LengthMass (Da)Tools
D0ESZ5 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: DC6A1728DA2A745D

FASTA39344,011
        10         20         30         40         50         60 
MQMSSALACL ILGLVLVSGK GFTLPLRESH TAHQATDFGV KVFQQVVQAS KDRNVVFSPY 

        70         80         90        100        110        120 
GVSSVLAMLQ MTTAGKTRRQ IQDAMGFKVN EKGTAHALRQ LSKELMGPWN KNEISTADAI 

       130        140        150        160        170        180 
FVQRDLELVQ GFMPHFFKLF QTMVKQVDFS EVERARFIIN DWVERHTKGM ISDLLAKGAV 

       190        200        210        220        230        240 
DELTRLVLVN ALYFSGQWKT PFLEASTHQR LFHKSDGSTV SVPMMAQSNK FNYTEFTTPD 

       250        260        270        280        290        300 
GLEYDVVELP YQGDTLSMFI AAPFEKDVHL SALTNILDAE LIRQWKGNMT RLPRLLILPK 

       310        320        330        340        350        360 
FSLETEVDLR GPLEKLGMPD MFSATLADFT SLSDQEQLSV AQALQKVRIE VNESGTVASS 

       370        380        390 
STAFVISARM APTEMVIDRS FLFVVRHNPT ETI 

« Hide

References

[1]"Polymorphisms in PAI-1 in A/J and C57BL/6J mice."
Sa Q., Hoover-Plow J.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL ACX48997.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GQ872458 mRNA. Translation: ACX48997.1.
UniGeneMm.250422.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000076728.

Proteomic databases

PRIDED0ESZ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97608. Serpine1.

Gene expression databases

ArrayExpressD0ESZ5.
BgeeD0ESZ5.

Family and domain databases

InterProIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
ProtoNetSearch...

Other

NextBio35548359.
SOURCESearch...

Entry information

Entry nameD0ESZ5_MOUSE
AccessionPrimary (citable) accession number: D0ESZ5
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)