D0ESZ5 (D0ESZ5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Serine or cysteine peptidase inhibitor clade E member 1 EMBL ACX48997.1

Gene names

Name:

Serpine1 EMBL ACX48997.1 MGI 97608

Organism

Mus musculus (Mouse) EMBL ACX48997.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	393 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the serpin family. RuleBase RU000411

Ontologies

Gene Ontology (GO)
Biological_process	angiogenesis Inferred from electronic annotation. Source: Compara cellular response to lipopolysaccharide Inferred from electronic annotation. Source: Compara chronological cell aging Inferred from electronic annotation. Source: Compara defense response to Gram-negative bacterium Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of cell adhesion mediated by integrin Inferred from electronic annotation. Source: Compara negative regulation of fibrinolysis Inferred from electronic annotation. Source: Compara negative regulation of plasminogen activation Inferred from electronic annotation. Source: Compara negative regulation of smooth muscle cell migration Inferred from electronic annotation. Source: Compara negative regulation of smooth muscle cell-matrix adhesion Inferred from electronic annotation. Source: Compara negative regulation of vascular wound healing Inferred from electronic annotation. Source: Compara positive regulation of angiogenesis Inferred from electronic annotation. Source: Compara positive regulation of interleukin-8 production Inferred from electronic annotation. Source: Compara positive regulation of leukotriene production involved in inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of monocyte chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of receptor-mediated endocytosis Inferred from electronic annotation. Source: Compara regulation of angiogenesis Inferred from direct assay PubMed 11818362. Source: MGI regulation of cell proliferation Inferred from genetic interaction PubMed 18258607. Source: MGI regulation of receptor activity Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular matrix Inferred from electronic annotation. Source: Compara extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from direct assay PubMed 15328353. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	393	1	EMBL ACX48997.1

Sequences

	Sequence		Length	Mass (Da)
	D0ESZ5 [UniParc]. Last modified November 24, 2009. Version 1. Checksum: DC6A1728DA2A745D	FASTA	393	44,011
	10 20 30 40 50 60 MQMSSALACL ILGLVLVSGK GFTLPLRESH TAHQATDFGV KVFQQVVQAS KDRNVVFSPY 70 80 90 100 110 120 GVSSVLAMLQ MTTAGKTRRQ IQDAMGFKVN EKGTAHALRQ LSKELMGPWN KNEISTADAI 130 140 150 160 170 180 FVQRDLELVQ GFMPHFFKLF QTMVKQVDFS EVERARFIIN DWVERHTKGM ISDLLAKGAV 190 200 210 220 230 240 DELTRLVLVN ALYFSGQWKT PFLEASTHQR LFHKSDGSTV SVPMMAQSNK FNYTEFTTPD 250 260 270 280 290 300 GLEYDVVELP YQGDTLSMFI AAPFEKDVHL SALTNILDAE LIRQWKGNMT RLPRLLILPK 310 320 330 340 350 360 FSLETEVDLR GPLEKLGMPD MFSATLADFT SLSDQEQLSV AQALQKVRIE VNESGTVASS 370 380 390 STAFVISARM APTEMVIDRS FLFVVRHNPT ETI

References

[1]	"Polymorphisms in PAI-1 in A/J and C57BL/6J mice." Sa Q., Hoover-Plow J. Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL ACX48997.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GQ872458 mRNA. Translation: ACX48997.1.
IPI	IPI00131547.
UniGene	Mm.250422.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000076728. D0ESZ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc009abn.2. mouse.
Organism-specific databases
MGI	MGI:97608. Serpine1.
Gene expression databases
ArrayExpress	D0ESZ5.
Bgee	D0ESZ5.
Family and domain databases
InterPro	IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
ProtoNet	Search...
Other
NextBio	35548359.
SOURCE	Search...

Entry information

Entry name

D0ESZ5_MOUSE

Accession

Primary (citable) accession number: D0ESZ5

Entry history

Integrated into UniProtKB/TrEMBL:	November 24, 2009
Last sequence update:	November 24, 2009
Last modified:	April 3, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)