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D0ESZ5

- D0ESZ5_MOUSE

UniProt

D0ESZ5 - D0ESZ5_MOUSE

Protein
Submitted name:

Serine or cysteine peptidase inhibitor clade E member 1

Gene

Serpine1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. serine-type endopeptidase inhibitor activity Source: MGI

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. cellular response to lipopolysaccharide Source: Ensembl
    3. chronological cell aging Source: Ensembl
    4. defense response to Gram-negative bacterium Source: Ensembl
    5. negative regulation of cell adhesion mediated by integrin Source: Ensembl
    6. negative regulation of endothelial cell apoptotic process Source: Ensembl
    7. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    8. negative regulation of fibrinolysis Source: Ensembl
    9. negative regulation of plasminogen activation Source: Ensembl
    10. negative regulation of smooth muscle cell-matrix adhesion Source: Ensembl
    11. negative regulation of smooth muscle cell migration Source: Ensembl
    12. negative regulation of vascular wound healing Source: Ensembl
    13. positive regulation of angiogenesis Source: Ensembl
    14. positive regulation of interleukin-8 production Source: Ensembl
    15. positive regulation of leukotriene production involved in inflammatory response Source: Ensembl
    16. positive regulation of monocyte chemotaxis Source: Ensembl
    17. positive regulation of receptor-mediated endocytosis Source: Ensembl
    18. regulation of angiogenesis Source: MGI
    19. regulation of cell proliferation Source: MGI
    20. regulation of receptor activity Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196606. ECM proteoglycans.
    REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Serine or cysteine peptidase inhibitor clade E member 1Imported
    Gene namesi
    Name:Serpine1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97608. Serpine1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular space Source: RefGenome

    PTM / Processingi

    Proteomic databases

    PRIDEiD0ESZ5.

    Expressioni

    Gene expression databases

    ArrayExpressiD0ESZ5.
    BgeeiD0ESZ5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000076728.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.UniRule annotation

    Family and domain databases

    InterProiIPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    D0ESZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQMSSALACL ILGLVLVSGK GFTLPLRESH TAHQATDFGV KVFQQVVQAS    50
    KDRNVVFSPY GVSSVLAMLQ MTTAGKTRRQ IQDAMGFKVN EKGTAHALRQ 100
    LSKELMGPWN KNEISTADAI FVQRDLELVQ GFMPHFFKLF QTMVKQVDFS 150
    EVERARFIIN DWVERHTKGM ISDLLAKGAV DELTRLVLVN ALYFSGQWKT 200
    PFLEASTHQR LFHKSDGSTV SVPMMAQSNK FNYTEFTTPD GLEYDVVELP 250
    YQGDTLSMFI AAPFEKDVHL SALTNILDAE LIRQWKGNMT RLPRLLILPK 300
    FSLETEVDLR GPLEKLGMPD MFSATLADFT SLSDQEQLSV AQALQKVRIE 350
    VNESGTVASS STAFVISARM APTEMVIDRS FLFVVRHNPT ETI 393
    Length:393
    Mass (Da):44,011
    Last modified:November 24, 2009 - v1
    Checksum:iDC6A1728DA2A745D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei393 – 3931Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ872458 mRNA. Translation: ACX48997.1.
    UniGeneiMm.250422.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ872458 mRNA. Translation: ACX48997.1 .
    UniGenei Mm.250422.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000076728.

    Proteomic databases

    PRIDEi D0ESZ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97608. Serpine1.

    Enzyme and pathway databases

    Reactomei REACT_196606. ECM proteoglycans.
    REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

    Miscellaneous databases

    NextBioi 35548359.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi D0ESZ5.
    Bgeei D0ESZ5.

    Family and domain databases

    InterProi IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Polymorphisms in PAI-1 in A/J and C57BL/6J mice."
      Sa Q., Hoover-Plow J.
      Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiD0ESZ5_MOUSE
    AccessioniPrimary (citable) accession number: D0ESZ5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 24, 2009
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)