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Protein
Submitted name:

Serine or cysteine peptidase inhibitor clade E member 1

Gene

Serpine1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. cellular response to lipopolysaccharide Source: Ensembl
  3. chronological cell aging Source: Ensembl
  4. defense response to Gram-negative bacterium Source: Ensembl
  5. negative regulation of cell adhesion mediated by integrin Source: Ensembl
  6. negative regulation of endothelial cell apoptotic process Source: Ensembl
  7. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  8. negative regulation of fibrinolysis Source: Ensembl
  9. negative regulation of plasminogen activation Source: Ensembl
  10. negative regulation of smooth muscle cell-matrix adhesion Source: Ensembl
  11. negative regulation of smooth muscle cell migration Source: Ensembl
  12. negative regulation of vascular wound healing Source: Ensembl
  13. positive regulation of angiogenesis Source: Ensembl
  14. positive regulation of interleukin-8 production Source: Ensembl
  15. positive regulation of leukotriene production involved in inflammatory response Source: Ensembl
  16. positive regulation of monocyte chemotaxis Source: Ensembl
  17. positive regulation of receptor-mediated endocytosis Source: Ensembl
  18. regulation of receptor activity Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_289519. Dissolution of Fibrin Clot.
REACT_307071. Platelet degranulation.
REACT_354321. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine or cysteine peptidase inhibitor clade E member 1Imported
Gene namesi
Name:Serpine1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97608. Serpine1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. extracellular space Source: GO_Central
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD0ESZ5.

Expressioni

Gene expression databases

BgeeiD0ESZ5.
ExpressionAtlasiD0ESZ5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076728.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Fragment.

D0ESZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQMSSALACL ILGLVLVSGK GFTLPLRESH TAHQATDFGV KVFQQVVQAS
60 70 80 90 100
KDRNVVFSPY GVSSVLAMLQ MTTAGKTRRQ IQDAMGFKVN EKGTAHALRQ
110 120 130 140 150
LSKELMGPWN KNEISTADAI FVQRDLELVQ GFMPHFFKLF QTMVKQVDFS
160 170 180 190 200
EVERARFIIN DWVERHTKGM ISDLLAKGAV DELTRLVLVN ALYFSGQWKT
210 220 230 240 250
PFLEASTHQR LFHKSDGSTV SVPMMAQSNK FNYTEFTTPD GLEYDVVELP
260 270 280 290 300
YQGDTLSMFI AAPFEKDVHL SALTNILDAE LIRQWKGNMT RLPRLLILPK
310 320 330 340 350
FSLETEVDLR GPLEKLGMPD MFSATLADFT SLSDQEQLSV AQALQKVRIE
360 370 380 390
VNESGTVASS STAFVISARM APTEMVIDRS FLFVVRHNPT ETI
Length:393
Mass (Da):44,011
Last modified:November 24, 2009 - v1
Checksum:iDC6A1728DA2A745D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei393 – 3931Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ872458 mRNA. Translation: ACX48997.1.
UniGeneiMm.250422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ872458 mRNA. Translation: ACX48997.1.
UniGeneiMm.250422.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076728.

Proteomic databases

PRIDEiD0ESZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97608. Serpine1.

Enzyme and pathway databases

ReactomeiREACT_289519. Dissolution of Fibrin Clot.
REACT_307071. Platelet degranulation.
REACT_354321. ECM proteoglycans.

Miscellaneous databases

NextBioi35548359.
SOURCEiSearch...

Gene expression databases

BgeeiD0ESZ5.
ExpressionAtlasiD0ESZ5. baseline and differential.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Polymorphisms in PAI-1 in A/J and C57BL/6J mice."
    Sa Q., Hoover-Plow J.
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD0ESZ5_MOUSE
AccessioniPrimary (citable) accession number: D0ESZ5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: April 1, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.