ID   D0EPX6_MOUSE            Unreviewed;       249 AA.
AC   D0EPX6;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   24-JAN-2024, entry version 89.
DE   RecName: Full=Peroxisome proliferator-activated receptor gamma {ECO:0000256|RuleBase:RU364110};
DE            Short=PPAR-gamma {ECO:0000256|RuleBase:RU364110};
DE   AltName: Full=Nuclear receptor subfamily 1 group C member 3 {ECO:0000256|RuleBase:RU364110};
DE   Flags: Fragment;
GN   Name=Pparg {ECO:0000313|MGI:MGI:97747};
GN   Synonyms=PPARG {ECO:0000256|RuleBase:RU364110};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:ACX47078.1};
RN   [1] {ECO:0000313|EMBL:ACX47078.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AKR/J {ECO:0000313|EMBL:ACX47080.1}, and SAMP1/YitFcs
RC   {ECO:0000313|EMBL:ACX47078.1};
RA   Spencer H.E., Kovach T.K., Hamilton J.B., Kazuhiko S., McDuffie M.;
RT   "Susceptibility to Crohn's disease associated with alternative transcripts
RT   of Pparg.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nuclear receptor that binds peroxisome proliferators such as
CC       hypolipidemic drugs and fatty acids. Once activated by a ligand, the
CC       nuclear receptor binds to DNA specific PPAR response elements (PPRE)
CC       and modulates the transcription of its target genes, such as acyl-CoA
CC       oxidase. It therefore controls the peroxisomal beta-oxidation pathway
CC       of fatty acids. Key regulator of adipocyte differentiation and glucose
CC       homeostasis. May play a role in the regulation of circadian rhythm.
CC       {ECO:0000256|RuleBase:RU364110}.
CC   -!- SUBUNIT: Heterodimer with other nuclear receptors.
CC       {ECO:0000256|RuleBase:RU364110}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU364110}.
CC       Nucleus {ECO:0000256|RuleBase:RU364110}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000256|ARBA:ARBA00008092,
CC       ECO:0000256|RuleBase:RU364110}.
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DR   EMBL; GQ868647; ACX47078.1; -; mRNA.
DR   EMBL; GQ868649; ACX47080.1; -; mRNA.
DR   AlphaFoldDB; D0EPX6; -.
DR   AGR; MGI:97747; -.
DR   MGI; MGI:97747; Pparg.
DR   ChiTaRS; Pparg; mouse.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   CDD; cd06965; NR_DBD_Ppar; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR003074; 1Cnucl_rcpt.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR003077; PPAR-gamma.
DR   InterPro; IPR022590; PPARgamma_N.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR   PANTHER; PTHR24082:SF488; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA; 1.
DR   Pfam; PF12577; PPARgamma_N; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR01288; PROXISOMEPAR.
DR   PRINTS; PR01291; PROXISOMPAGR.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Activator {ECO:0000256|RuleBase:RU364110};
KW   Biological rhythms {ECO:0000256|RuleBase:RU364110};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU364110};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU364110};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU364110};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364110};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU364110};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU364110};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU364110};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU364110};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU364110}.
FT   DOMAIN          70..144
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACX47078.1"
FT   NON_TER         249
FT                   /evidence="ECO:0000313|EMBL:ACX47078.1"
SQ   SEQUENCE   249 AA;  28616 MW;  42B592B8858B4930 CRC64;
     TVDFSSISAP HYEDIPFTRA DPMVADYKYD LKLQEYQSAI KVEPASPPYY SEKTQLYNRP
     HEEPSNSLMA IECRVCGDKA SGFHYGVHAC EGCKGFFRRT IRLKLIYDRC DLNCRIHKKS
     RNKCQYCRFQ KCLAVGMSHN AIRFGRMPQA EKEKLLAEIS SDIDQLNPES ADLRALAKHL
     YDSYIKSFPL TKAKARAILT GKTTDKSPFV IYDMNSLMMG EDKIKFKHIT PLQEQSKEVA
     IRIFQGCQF
//