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Protein
Submitted name:

Peroxisome proliferator activator receptor gamma

Gene

Pparg

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • brown fat cell differentiation Source: MGI
  • cell fate commitment Source: MGI
  • cell maturation Source: MGI
  • cellular response to insulin stimulus Source: MGI
  • cellular response to lithium ion Source: MGI
  • cellular response to organic cyclic compound Source: MGI
  • diet induced thermogenesis Source: MGI
  • epithelial cell differentiation Source: MGI
  • fat cell differentiation Source: MGI
  • glucose homeostasis Source: MGI
  • inflammatory response Source: MGI
  • lipoprotein transport Source: MGI
  • long-chain fatty acid transport Source: MGI
  • low-density lipoprotein particle receptor biosynthetic process Source: MGI
  • monocyte differentiation Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of cholesterol storage Source: MGI
  • negative regulation of interferon-gamma-mediated signaling pathway Source: MGI
  • negative regulation of macrophage derived foam cell differentiation Source: MGI
  • negative regulation of receptor biosynthetic process Source: MGI
  • negative regulation of sequestering of triglyceride Source: MGI
  • negative regulation of smooth muscle cell proliferation Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • peroxisome proliferator activated receptor signaling pathway Source: MGI
  • placenta development Source: MGI
  • positive regulation of fat cell differentiation Source: MGI
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of blood pressure Source: MGI
  • regulation of fat cell differentiation Source: MGI
  • regulation of gene expression Source: MGI
  • response to dietary excess Source: MGI
  • response to low-density lipoprotein particle Source: MGI
  • response to retinoic acid Source: MGI
  • signal transduction Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
  • white fat cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.
REACT_309805. Transcriptional regulation of white adipocyte differentiation.

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferator activator receptor gammaImported
Gene namesi
Name:PpargImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97747. Pparg.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • nucleus Source: MGI
  • RNA polymerase II transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000450.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR022590. PPARgamma_N.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D0EPX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TVDFSSISAP HYEDIPFTRA DPMVADYKYD LKLQEYQSAI KVEPASPPYY
60 70 80 90 100
SEKTQLYNRP HEEPSNSLMA IECRVCGDKA SGFHYGVHAC EGCKGFFRRT
110 120 130 140 150
IRLKLIYDRC DLNCRIHKKS RNKCQYCRFQ KCLAVGMSHN AIRFGRMPQA
160 170 180 190 200
EKEKLLAEIS SDIDQLNPES ADLRALAKHL YDSYIKSFPL TKAKARAILT
210 220 230 240
GKTTDKSPFV IYDMNSLMMG EDKIKFKHIT PLQEQSKEVA IRIFQGCQF
Length:249
Mass (Da):28,616
Last modified:November 24, 2009 - v1
Checksum:i42B592B8858B4930
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei249 – 2491Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ868647 mRNA. Translation: ACX47078.1.
GQ868649 mRNA. Translation: ACX47080.1.
UniGeneiMm.3020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ868647 mRNA. Translation: ACX47078.1.
GQ868649 mRNA. Translation: ACX47080.1.
UniGeneiMm.3020.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97747. Pparg.

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.
REACT_309805. Transcriptional regulation of white adipocyte differentiation.

Miscellaneous databases

NextBioi35548355.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR022590. PPARgamma_N.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Susceptibility to Crohn's disease associated with alternative transcripts of Pparg."
    Spencer H.E., Kovach T.K., Hamilton J.B., Kazuhiko S., McDuffie M.
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AKR/JImported and SAMP1/YitFcsImported.

Entry informationi

Entry nameiD0EPX6_MOUSE
AccessioniPrimary (citable) accession number: D0EPX6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: July 22, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.