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Protein

Peroxisome proliferator-activated receptor gamma

Gene

Pparg

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi70 – 144Nuclear receptorPROSITE-ProRule annotationAdd BLAST75

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationImported
Biological processBiological rhythmsUniRule annotation, Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gammaUniRule annotation
Short name:
PPAR-gammaUniRule annotation
Alternative name(s):
Nuclear receptor subfamily 1 group C member 3UniRule annotation
Gene namesi
Name:PpargImported
Synonyms:PPARGUniRule annotation
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97747. Pparg.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusPROSITE-ProRule annotationSAAS annotation

Interactioni

Subunit structurei

Heterodimer with other nuclear receptors.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 144Nuclear receptorInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR1 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR035500. NHR_like_dom_sf.
IPR022590. PPARgamma_N.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

D0EPX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TVDFSSISAP HYEDIPFTRA DPMVADYKYD LKLQEYQSAI KVEPASPPYY
60 70 80 90 100
SEKTQLYNRP HEEPSNSLMA IECRVCGDKA SGFHYGVHAC EGCKGFFRRT
110 120 130 140 150
IRLKLIYDRC DLNCRIHKKS RNKCQYCRFQ KCLAVGMSHN AIRFGRMPQA
160 170 180 190 200
EKEKLLAEIS SDIDQLNPES ADLRALAKHL YDSYIKSFPL TKAKARAILT
210 220 230 240
GKTTDKSPFV IYDMNSLMMG EDKIKFKHIT PLQEQSKEVA IRIFQGCQF
Length:249
Mass (Da):28,616
Last modified:November 24, 2009 - v1
Checksum:i42B592B8858B4930
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei249Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ868647 mRNA. Translation: ACX47078.1.
GQ868649 mRNA. Translation: ACX47080.1.
UniGeneiMm.3020.

Similar proteinsi

Entry informationi

Entry nameiD0EPX6_MOUSE
AccessioniPrimary (citable) accession number: D0EPX6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: November 22, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)