D0EPX6 (D0EPX6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Peroxisome proliferator activator receptor gamma EMBL ACX47078.1

Gene names

Name:

Pparg MGI 97747

Organism

Mus musculus (Mouse) EMBL ACX47078.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	249 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS001628

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS001628
Cellular component	Nucleus SAAS SAAS001628
Domain	Zinc-finger SAAS SAAS001628
Ligand	DNA-binding SAAS SAAS001628 Metal-binding Zinc
Molecular function	Receptor EMBL ACX47078.1
Gene Ontology (GO)
Biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara brown fat cell differentiation Inferred from direct assay PubMed 18492766. Source: MGI cell fate commitment Inferred from genetic interaction PubMed 15687259. Source: MGI cell maturation Inferred from electronic annotation. Source: Compara cellular response to insulin stimulus Inferred from electronic annotation. Source: Compara cellular response to lithium ion Inferred from direct assay PubMed 15673614. Source: MGI epithelial cell differentiation Inferred from genetic interaction PubMed 15687259. Source: MGI fatty acid oxidation Inferred from electronic annotation. Source: Compara glucose homeostasis Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara induction of apoptosis Inferred from electronic annotation. Source: Compara inflammatory response Traceable author statement PubMed 12163159. Source: MGI lipoprotein transport Inferred from electronic annotation. Source: Compara long-chain fatty acid transport Inferred from mutant phenotype PubMed 17463056. Source: MGI low-density lipoprotein particle receptor biosynthetic process Inferred from electronic annotation. Source: Compara monocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of acute inflammatory response Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from mutant phenotype PubMed 12370429. Source: MGI negative regulation of cholesterol storage Inferred from electronic annotation. Source: Compara negative regulation of interferon-gamma-mediated signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of receptor biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of sequestering of triglyceride Inferred from electronic annotation. Source: Compara negative regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of telomerase activity Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 8041794. Source: MGI organ regeneration Inferred from electronic annotation. Source: Compara peroxisome proliferator activated receptor signaling pathway Inferred from electronic annotation. Source: Compara placenta development Inferred from mutant phenotype PubMed 17463056. Source: MGI positive regulation of fat cell differentiation Inferred from direct assay PubMed 10937998PubMed 15175325PubMed 15728361. Source: MGI positive regulation of fatty acid oxidation Inferred from electronic annotation. Source: Compara positive regulation of oligodendrocyte differentiation Inferred from electronic annotation. Source: Compara positive regulation of sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 12037571PubMed 16099986. Source: MGI regulation of blood pressure Inferred from electronic annotation. Source: Compara response to caffeine Inferred from electronic annotation. Source: Compara response to cold Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to estrogen stimulus Inferred from electronic annotation. Source: Compara response to low-density lipoprotein particle stimulus Inferred from electronic annotation. Source: Compara response to retinoic acid Inferred from electronic annotation. Source: Compara response to vitamin A Inferred from electronic annotation. Source: Compara steroid hormone mediated signaling pathway Inferred from electronic annotation. Source: GOC white fat cell differentiation Inferred from direct assay PubMed 18492766. Source: MGI
Cellular_component	cytosol Inferred from direct assay PubMed 12163159PubMed 15164767. Source: MGI nucleus Inferred from direct assay PubMed 12163159PubMed 15164767PubMed 21669876. Source: MGI
Molecular_function	RNA polymerase II regulatory region DNA binding Inferred from direct assay PubMed 15175325. Source: MGI chromatin binding Inferred from direct assay PubMed 19066220. Source: MGI drug binding Inferred from electronic annotation. Source: Compara ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Traceable author statement PubMed 12163159. Source: MGI ligand-dependent nuclear receptor transcription coactivator activity Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL ACX47078.1
	Non-terminal residue	249	1	EMBL ACX47078.1

Sequences

	Sequence		Length	Mass (Da)
	D0EPX6 [UniParc]. Last modified November 24, 2009. Version 1. Checksum: 42B592B8858B4930	FASTA	249	28,616
	10 20 30 40 50 60 TVDFSSISAP HYEDIPFTRA DPMVADYKYD LKLQEYQSAI KVEPASPPYY SEKTQLYNRP 70 80 90 100 110 120 HEEPSNSLMA IECRVCGDKA SGFHYGVHAC EGCKGFFRRT IRLKLIYDRC DLNCRIHKKS 130 140 150 160 170 180 RNKCQYCRFQ KCLAVGMSHN AIRFGRMPQA EKEKLLAEIS SDIDQLNPES ADLRALAKHL 190 200 210 220 230 240 YDSYIKSFPL TKAKARAILT GKTTDKSPFV IYDMNSLMMG EDKIKFKHIT PLQEQSKEVA IRIFQGCQF

References

[1]	"Susceptibility to Crohn's disease associated with alternative transcripts of Pparg." Spencer H.E., Kovach T.K., Hamilton J.B., Kazuhiko S., McDuffie M. Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: AKR/J EMBL ACX47080.1 and SAMP1/YitFcs EMBL ACX47078.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GQ868647 mRNA. Translation: ACX47078.1. GQ868649 mRNA. Translation: ACX47080.1.
IPI	IPI00896034.
UniGene	Mm.3020.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:97747. Pparg.
Family and domain databases
Gene3D	1.10.565.10. 2 hits. 3.30.50.10. 1 hit.
InterPro	IPR003074. 1Cnucl_rcpt. IPR003077. 1Cnucl_rcpt_G. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR022590. PPARgamma_N. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF12577. PPARgamma_N. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR01288. PROXISOMEPAR. PR01291. PROXISOMPAGR. PR00047. STROIDFINGER.
SMART	SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35548355.
SOURCE	Search...

Entry information

Entry name

D0EPX6_MOUSE

Accession

Primary (citable) accession number: D0EPX6

Entry history

Integrated into UniProtKB/TrEMBL:	November 24, 2009
Last sequence update:	November 24, 2009
Last modified:	May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)