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D0EPX6 (D0EPX6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Pparg MGI 97747
OrganismMus musculus (Mouse) EMBL ACX47078.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length249 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377

Contains nuclear receptor DNA-binding domain. SAAS SAAS008946

Ontologies

Keywords
   Biological processTranscription
Transcription regulation SAAS SAAS008946
   Cellular componentNucleus SAAS SAAS008946
   DomainZinc-finger SAAS SAAS008946
   LigandDNA-binding SAAS SAAS008946
Metal-binding
Zinc
   Molecular functionReceptor EMBL ACX47078.1
Gene Ontology (GO)
   Biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

brown fat cell differentiation

Inferred from direct assay PubMed 18492766. Source: MGI

cell fate commitment

Inferred from genetic interaction PubMed 15687259. Source: MGI

cell maturation

Inferred from electronic annotation. Source: Ensembl

cellular response to insulin stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to lithium ion

Inferred from direct assay PubMed 15673614. Source: MGI

cellular response to organic cyclic compound

Inferred from direct assay PubMed 12055200. Source: MGI

epithelial cell differentiation

Inferred from genetic interaction PubMed 15687259. Source: MGI

fat cell differentiation

Inferred from direct assay PubMed 12037571PubMed 12502791. Source: MGI

fatty acid oxidation

Inferred from electronic annotation. Source: Ensembl

glucose homeostasis

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Traceable author statement PubMed 12163159. Source: MGI

lipoprotein transport

Inferred from electronic annotation. Source: Ensembl

long-chain fatty acid transport

Inferred from mutant phenotype PubMed 17463056. Source: MGI

low-density lipoprotein particle receptor biosynthetic process

Inferred from electronic annotation. Source: Ensembl

monocyte differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of acute inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 12370429. Source: MGI

negative regulation of cholesterol storage

Inferred from electronic annotation. Source: Ensembl

negative regulation of interferon-gamma-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of receptor biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of sequestering of triglyceride

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of telomerase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 8041794. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 15681609. Source: MGI

organ regeneration

Inferred from electronic annotation. Source: Ensembl

peroxisome proliferator activated receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

placenta development

Inferred from mutant phenotype PubMed 17463056. Source: MGI

positive regulation of fat cell differentiation

Inferred from direct assay PubMed 10937998PubMed 15175325PubMed 15728361. Source: MGI

positive regulation of fatty acid oxidation

Inferred from electronic annotation. Source: Ensembl

positive regulation of oligodendrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12037571PubMed 16099986PubMed 22226965. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 14744933PubMed 15684432. Source: MGI

regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

regulation of fat cell differentiation

Inferred from direct assay PubMed 12097321. Source: MGI

response to caffeine

Inferred from electronic annotation. Source: Ensembl

response to cold

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estrogen

Inferred from electronic annotation. Source: Ensembl

response to low-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

response to vitamin A

Inferred from electronic annotation. Source: Ensembl

white fat cell differentiation

Inferred from direct assay PubMed 18492766. Source: MGI

   Cellular_componentcytosol

Inferred from direct assay PubMed 12163159PubMed 15164767. Source: MGI

nucleus

Inferred from direct assay PubMed 12163159PubMed 15164767PubMed 21669876. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 12037571PubMed 15232616PubMed 15681609PubMed 8041794. Source: MGI

RNA polymerase II regulatory region DNA binding

Inferred from direct assay PubMed 15175325. Source: MGI

RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from direct assay PubMed 23275342. Source: MGI

chromatin binding

Inferred from direct assay PubMed 19066220PubMed 23275342PubMed 23499423. Source: MGI

drug binding

Inferred from electronic annotation. Source: Ensembl

ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

Traceable author statement PubMed 12163159. Source: MGI

ligand-dependent nuclear receptor transcription coactivator activity

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 15681609PubMed 16099986. Source: MGI

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 12037571. Source: MGI

steroid hormone receptor activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL ACX47078.1
Non-terminal residue2491 EMBL ACX47078.1

Sequences

Sequence LengthMass (Da)Tools
D0EPX6 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 42B592B8858B4930

FASTA24928,616
        10         20         30         40         50         60 
TVDFSSISAP HYEDIPFTRA DPMVADYKYD LKLQEYQSAI KVEPASPPYY SEKTQLYNRP 

        70         80         90        100        110        120 
HEEPSNSLMA IECRVCGDKA SGFHYGVHAC EGCKGFFRRT IRLKLIYDRC DLNCRIHKKS 

       130        140        150        160        170        180 
RNKCQYCRFQ KCLAVGMSHN AIRFGRMPQA EKEKLLAEIS SDIDQLNPES ADLRALAKHL 

       190        200        210        220        230        240 
YDSYIKSFPL TKAKARAILT GKTTDKSPFV IYDMNSLMMG EDKIKFKHIT PLQEQSKEVA 


IRIFQGCQF 

« Hide

References

[1]"Susceptibility to Crohn's disease associated with alternative transcripts of Pparg."
Spencer H.E., Kovach T.K., Hamilton J.B., Kazuhiko S., McDuffie M.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: AKR/J EMBL ACX47080.1 and SAMP1/YitFcs EMBL ACX47078.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GQ868647 mRNA. Translation: ACX47078.1.
GQ868649 mRNA. Translation: ACX47080.1.
UniGeneMm.3020.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97747. Pparg.

Family and domain databases

Gene3D1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProIPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR022590. PPARgamma_N.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00047. STROIDFINGER.
SMARTSM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35548355.
SOURCESearch...

Entry information

Entry nameD0EPX6_MOUSE
AccessionPrimary (citable) accession number: D0EPX6
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)