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D0EPX6

- D0EPX6_MOUSE

UniProt

D0EPX6 - D0EPX6_MOUSE

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Protein
Submitted name: Peroxisome proliferator activator receptor gamma
Gene
Pparg
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II regulatory region DNA binding Source: MGI
  3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  4. chromatin binding Source: MGI
  5. drug binding Source: Ensembl
  6. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  7. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
  8. protein binding Source: MGI
  9. sequence-specific DNA binding Source: InterPro
  10. sequence-specific DNA binding transcription factor activity Source: MGI
  11. steroid hormone receptor activity Source: InterPro
  12. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. brown fat cell differentiation Source: MGI
  3. cell fate commitment Source: MGI
  4. cell maturation Source: Ensembl
  5. cellular response to insulin stimulus Source: Ensembl
  6. cellular response to lithium ion Source: MGI
  7. cellular response to organic cyclic compound Source: MGI
  8. epithelial cell differentiation Source: MGI
  9. fat cell differentiation Source: MGI
  10. fatty acid oxidation Source: Ensembl
  11. glucose homeostasis Source: Ensembl
  12. heart development Source: Ensembl
  13. inflammatory response Source: MGI
  14. lipoprotein transport Source: Ensembl
  15. long-chain fatty acid transport Source: MGI
  16. low-density lipoprotein particle receptor biosynthetic process Source: Ensembl
  17. monocyte differentiation Source: Ensembl
  18. negative regulation of acute inflammatory response Source: Ensembl
  19. negative regulation of cell growth Source: Ensembl
  20. negative regulation of cell proliferation Source: MGI
  21. negative regulation of cholesterol storage Source: Ensembl
  22. negative regulation of interferon-gamma-mediated signaling pathway Source: Ensembl
  23. negative regulation of receptor biosynthetic process Source: Ensembl
  24. negative regulation of sequestering of triglyceride Source: Ensembl
  25. negative regulation of smooth muscle cell proliferation Source: Ensembl
  26. negative regulation of telomerase activity Source: Ensembl
  27. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  28. negative regulation of transcription, DNA-templated Source: MGI
  29. organ regeneration Source: Ensembl
  30. peroxisome proliferator activated receptor signaling pathway Source: Ensembl
  31. placenta development Source: MGI
  32. positive regulation of fat cell differentiation Source: MGI
  33. positive regulation of fatty acid oxidation Source: Ensembl
  34. positive regulation of oligodendrocyte differentiation Source: Ensembl
  35. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  36. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  37. positive regulation of transcription, DNA-templated Source: MGI
  38. regulation of blood pressure Source: Ensembl
  39. regulation of fat cell differentiation Source: MGI
  40. response to caffeine Source: Ensembl
  41. response to cold Source: Ensembl
  42. response to drug Source: Ensembl
  43. response to estrogen Source: Ensembl
  44. response to low-density lipoprotein particle Source: Ensembl
  45. response to retinoic acid Source: Ensembl
  46. response to vitamin A Source: Ensembl
  47. white fat cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Keywords - Ligandi

DNA-bindingSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferator activator receptor gammaImported
Gene namesi
Name:PpargImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97747. Pparg.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR022590. PPARgamma_N.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D0EPX6-1 [UniParc]FASTAAdd to Basket

« Hide

TVDFSSISAP HYEDIPFTRA DPMVADYKYD LKLQEYQSAI KVEPASPPYY    50
SEKTQLYNRP HEEPSNSLMA IECRVCGDKA SGFHYGVHAC EGCKGFFRRT 100
IRLKLIYDRC DLNCRIHKKS RNKCQYCRFQ KCLAVGMSHN AIRFGRMPQA 150
EKEKLLAEIS SDIDQLNPES ADLRALAKHL YDSYIKSFPL TKAKARAILT 200
GKTTDKSPFV IYDMNSLMMG EDKIKFKHIT PLQEQSKEVA IRIFQGCQF 249
Length:249
Mass (Da):28,616
Last modified:November 24, 2009 - v1
Checksum:i42B592B8858B4930
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei249 – 2491Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ868647 mRNA. Translation: ACX47078.1.
GQ868649 mRNA. Translation: ACX47080.1.
UniGeneiMm.3020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ868647 mRNA. Translation: ACX47078.1 .
GQ868649 mRNA. Translation: ACX47080.1 .
UniGenei Mm.3020.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:97747. Pparg.

Miscellaneous databases

NextBioi 35548355.
SOURCEi Search...

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR022590. PPARgamma_N.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00047. STROIDFINGER.
SMARTi SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Susceptibility to Crohn's disease associated with alternative transcripts of Pparg."
    Spencer H.E., Kovach T.K., Hamilton J.B., Kazuhiko S., McDuffie M.
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AKR/JImported and SAMP1/YitFcsImported.

Entry informationi

Entry nameiD0EPX6_MOUSE
AccessioniPrimary (citable) accession number: D0EPX6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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