Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

D0EPX6

- D0EPX6_MOUSE

UniProt

D0EPX6 - D0EPX6_MOUSE

Protein
Submitted name:

Peroxisome proliferator activator receptor gamma

Gene

Pparg

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (24 Nov 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. drug binding Source: Ensembl
    4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    5. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
    6. protein binding Source: MGI
    7. RNA polymerase II regulatory region DNA binding Source: MGI
    8. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
    9. sequence-specific DNA binding Source: InterPro
    10. sequence-specific DNA binding transcription factor activity Source: MGI
    11. steroid hormone receptor activity Source: InterPro
    12. zinc ion binding Source: InterPro

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. brown fat cell differentiation Source: MGI
    3. cell fate commitment Source: MGI
    4. cell maturation Source: Ensembl
    5. cellular response to insulin stimulus Source: Ensembl
    6. cellular response to lithium ion Source: MGI
    7. cellular response to organic cyclic compound Source: MGI
    8. epithelial cell differentiation Source: MGI
    9. fat cell differentiation Source: MGI
    10. fatty acid oxidation Source: Ensembl
    11. glucose homeostasis Source: Ensembl
    12. heart development Source: Ensembl
    13. inflammatory response Source: MGI
    14. lipoprotein transport Source: Ensembl
    15. long-chain fatty acid transport Source: MGI
    16. low-density lipoprotein particle receptor biosynthetic process Source: Ensembl
    17. monocyte differentiation Source: Ensembl
    18. negative regulation of acute inflammatory response Source: Ensembl
    19. negative regulation of cell growth Source: Ensembl
    20. negative regulation of cell proliferation Source: MGI
    21. negative regulation of cholesterol storage Source: Ensembl
    22. negative regulation of interferon-gamma-mediated signaling pathway Source: Ensembl
    23. negative regulation of receptor biosynthetic process Source: Ensembl
    24. negative regulation of sequestering of triglyceride Source: Ensembl
    25. negative regulation of smooth muscle cell proliferation Source: Ensembl
    26. negative regulation of telomerase activity Source: Ensembl
    27. negative regulation of transcription, DNA-templated Source: MGI
    28. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    29. organ regeneration Source: Ensembl
    30. peroxisome proliferator activated receptor signaling pathway Source: Ensembl
    31. placenta development Source: MGI
    32. positive regulation of fat cell differentiation Source: MGI
    33. positive regulation of fatty acid oxidation Source: Ensembl
    34. positive regulation of oligodendrocyte differentiation Source: Ensembl
    35. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    36. positive regulation of transcription, DNA-templated Source: MGI
    37. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    38. regulation of blood pressure Source: Ensembl
    39. regulation of fat cell differentiation Source: MGI
    40. response to caffeine Source: Ensembl
    41. response to cold Source: Ensembl
    42. response to drug Source: Ensembl
    43. response to estrogen Source: Ensembl
    44. response to low-density lipoprotein particle Source: Ensembl
    45. response to retinoic acid Source: Ensembl
    46. response to vitamin A Source: Ensembl
    47. white fat cell differentiation Source: MGI

    Keywords - Molecular functioni

    ReceptorImported

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Peroxisome proliferator activator receptor gammaImported
    Gene namesi
    Name:PpargImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97747. Pparg.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR003074. 1Cnucl_rcpt.
    IPR003077. 1Cnucl_rcpt_G.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR022590. PPARgamma_N.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF12577. PPARgamma_N. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01288. PROXISOMEPAR.
    PR01291. PROXISOMPAGR.
    PR00047. STROIDFINGER.
    SMARTiSM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    D0EPX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    TVDFSSISAP HYEDIPFTRA DPMVADYKYD LKLQEYQSAI KVEPASPPYY    50
    SEKTQLYNRP HEEPSNSLMA IECRVCGDKA SGFHYGVHAC EGCKGFFRRT 100
    IRLKLIYDRC DLNCRIHKKS RNKCQYCRFQ KCLAVGMSHN AIRFGRMPQA 150
    EKEKLLAEIS SDIDQLNPES ADLRALAKHL YDSYIKSFPL TKAKARAILT 200
    GKTTDKSPFV IYDMNSLMMG EDKIKFKHIT PLQEQSKEVA IRIFQGCQF 249
    Length:249
    Mass (Da):28,616
    Last modified:November 24, 2009 - v1
    Checksum:i42B592B8858B4930
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei249 – 2491Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ868647 mRNA. Translation: ACX47078.1.
    GQ868649 mRNA. Translation: ACX47080.1.
    UniGeneiMm.3020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ868647 mRNA. Translation: ACX47078.1 .
    GQ868649 mRNA. Translation: ACX47080.1 .
    UniGenei Mm.3020.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97747. Pparg.

    Miscellaneous databases

    NextBioi 35548355.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR003074. 1Cnucl_rcpt.
    IPR003077. 1Cnucl_rcpt_G.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR022590. PPARgamma_N.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF12577. PPARgamma_N. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01288. PROXISOMEPAR.
    PR01291. PROXISOMPAGR.
    PR00047. STROIDFINGER.
    SMARTi SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Susceptibility to Crohn's disease associated with alternative transcripts of Pparg."
      Spencer H.E., Kovach T.K., Hamilton J.B., Kazuhiko S., McDuffie M.
      Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: AKR/JImported and SAMP1/YitFcsImported.

    Entry informationi

    Entry nameiD0EPX6_MOUSE
    AccessioniPrimary (citable) accession number: D0EPX6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 24, 2009
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)