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Protein

C-C motif chemokine

Gene

CCL5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotation

Keywords - Biological processi

ChemotaxisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokineUniRule annotation
Gene namesi
Name:CCL5Imported
ORF Names:hCG_32592Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_500845040524 – 91C-C motif chemokineUniRule annotationAdd BLAST68

Expressioni

Gene expression databases

BgeeiENSG00000161570.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000293272.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 88SCYInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the intercrine beta (chemokine CC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J0XH. Eukaryota.
ENOG410ZUYI. LUCA.
KOiK12499.
OrthoDBiEOG091G0QTP.

Family and domain databases

InterProiIPR030595. CCL5.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF82. PTHR12015:SF82. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0EI67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAAALAV ILIATALCAP ASASPYSSDT TPCCFAYIAR PLPRAHIKEY
60 70 80 90
FYTSGKCSNP AVVFVTRKNR QVCANPEKKW VREYINSLEM S
Length:91
Mass (Da):9,990
Last modified:November 24, 2009 - v1
Checksum:iFB0BFAF9A87C620F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ504011 Genomic DNA. Translation: ACW84342.1.
CH471147 Genomic DNA. Translation: EAW80120.1.
RefSeqiNP_002976.2. NM_002985.2.
UniGeneiHs.514821.

Genome annotation databases

GeneIDi6352.
KEGGihsa:6352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ504011 Genomic DNA. Translation: ACW84342.1.
CH471147 Genomic DNA. Translation: EAW80120.1.
RefSeqiNP_002976.2. NM_002985.2.
UniGeneiHs.514821.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000293272.

Protocols and materials databases

DNASUi6352.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6352.
KEGGihsa:6352.

Organism-specific databases

CTDi6352.
PharmGKBiPA35564.

Phylogenomic databases

eggNOGiENOG410J0XH. Eukaryota.
ENOG410ZUYI. LUCA.
KOiK12499.
OrthoDBiEOG091G0QTP.

Miscellaneous databases

GenomeRNAii6352.

Gene expression databases

BgeeiENSG00000161570.

Family and domain databases

InterProiIPR030595. CCL5.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF82. PTHR12015:SF82. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD0EI67_HUMAN
AccessioniPrimary (citable) accession number: D0EI67
Secondary accession number(s): A0A0G2JQ43
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.