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Protein

C-C motif chemokine

Gene

CCL5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation
Biological processChemotaxisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokineUniRule annotation
Gene namesi
Name:CCL5Imported
ORF Names:hCG_32592Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_500845040524 – 91C-C motif chemokineUniRule annotationAdd BLAST68

Expressioni

Gene expression databases

BgeeiENSG00000161570.
ExpressionAtlasiD0EI67. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000293272.

Structurei

3D structure databases

ProteinModelPortaliD0EI67.
SMRiD0EI67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 88SCYInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the intercrine beta (chemokine CC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J0XH. Eukaryota.
ENOG410ZUYI. LUCA.
KOiK12499.
OrthoDBiEOG091G0QTP.
PhylomeDBiD0EI67.

Family and domain databases

InterProiView protein in InterPro
IPR030595. CCL5.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PANTHERiPTHR12015:SF136. PTHR12015:SF136. 1 hit.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Complete.

D0EI67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAAALAV ILIATALCAP ASASPYSSDT TPCCFAYIAR PLPRAHIKEY
60 70 80 90
FYTSGKCSNP AVVFVTRKNR QVCANPEKKW VREYINSLEM S
Length:91
Mass (Da):9,990
Last modified:November 24, 2009 - v1
Checksum:iFB0BFAF9A87C620F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ504011 Genomic DNA. Translation: ACW84342.1.
CH471147 Genomic DNA. Translation: EAW80120.1.
RefSeqiNP_002976.2. NM_002985.2.
UniGeneiHs.514821.

Genome annotation databases

GeneIDi6352.
KEGGihsa:6352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ504011 Genomic DNA. Translation: ACW84342.1.
CH471147 Genomic DNA. Translation: EAW80120.1.
RefSeqiNP_002976.2. NM_002985.2.
UniGeneiHs.514821.

3D structure databases

ProteinModelPortaliD0EI67.
SMRiD0EI67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000293272.

Protocols and materials databases

DNASUi6352.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6352.
KEGGihsa:6352.

Organism-specific databases

CTDi6352.
PharmGKBiPA35564.

Phylogenomic databases

eggNOGiENOG410J0XH. Eukaryota.
ENOG410ZUYI. LUCA.
KOiK12499.
OrthoDBiEOG091G0QTP.
PhylomeDBiD0EI67.

Miscellaneous databases

GenomeRNAii6352.

Gene expression databases

BgeeiENSG00000161570.
ExpressionAtlasiD0EI67. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR030595. CCL5.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PANTHERiPTHR12015:SF136. PTHR12015:SF136. 1 hit.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD0EI67_HUMAN
AccessioniPrimary (citable) accession number: D0EI67
Secondary accession number(s): A0A0G2JQ43
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: April 12, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.