Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Zinc finger protein 423

Gene

znf423

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • Notch signaling pathway Source: UniProtKB
  • positive regulation of BMP signaling pathway Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Zinc finger protein 423Imported
Gene namesi
Name:znf423Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6457352. znf423.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliD0E8G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 9123C2H2-typeInterPro annotationAdd
BLAST
Domaini140 – 16728C2H2-typeInterPro annotationAdd
BLAST
Domaini168 – 19528C2H2-typeInterPro annotationAdd
BLAST
Domaini196 – 22328C2H2-typeInterPro annotationAdd
BLAST
Domaini224 – 25128C2H2-typeInterPro annotationAdd
BLAST
Domaini265 – 29329C2H2-typeInterPro annotationAdd
BLAST
Domaini297 – 32529C2H2-typeInterPro annotationAdd
BLAST
Domaini486 – 51429C2H2-typeInterPro annotationAdd
BLAST
Domaini523 – 54624C2H2-typeInterPro annotationAdd
BLAST
Domaini638 – 66023C2H2-typeInterPro annotationAdd
BLAST
Domaini668 – 69023C2H2-typeInterPro annotationAdd
BLAST
Domaini698 – 72225C2H2-typeInterPro annotationAdd
BLAST
Domaini726 – 75429C2H2-typeInterPro annotationAdd
BLAST
Domaini756 – 78429C2H2-typeInterPro annotationAdd
BLAST
Domaini787 – 81428C2H2-typeInterPro annotationAdd
BLAST
Domaini813 – 83624C2H2-typeInterPro annotationAdd
BLAST
Domaini891 – 91828C2H2-typeInterPro annotationAdd
BLAST
Domaini935 – 96228C2H2-typeInterPro annotationAdd
BLAST
Domaini964 – 99128C2H2-typeInterPro annotationAdd
BLAST
Domaini1125 – 115834C2H2-typeInterPro annotationAdd
BLAST
Domaini1173 – 120028C2H2-typeInterPro annotationAdd
BLAST
Domaini1203 – 123028C2H2-typeInterPro annotationAdd
BLAST
Domaini1234 – 126229C2H2-typeInterPro annotationAdd
BLAST
Domaini1264 – 128926C2H2-typeInterPro annotationAdd
BLAST

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 30 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 28 hits.
PS50157. ZINC_FINGER_C2H2_2. 24 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0E8G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRKQAKPR SVKVEDAEDF GLNWESTVNQ TGGLDRETDG EGQTLEDGNS
60 70 80 90 100
MTSQEERIEE EELEDESIYT CDNCQQDFDS LAELTEHRTQ HCLGDGDDDP
110 120 130 140 150
QFSWVPSSPS SKDVASPTPI IGDGCDLGIG EEEGGSGLPY PCQFCDKSFS
160 170 180 190 200
RLSYLKRHEQ IHSDKLPFKC TYCSRLFKHK RSRDRHIKLH TGDKKYHCHE
210 220 230 240 250
CEAAFSRSDH LKIHLKTHSS SKPFKCTVCK RGFSSTSSLQ SHMQAHRKNK
260 270 280 290 300
EYMTKSDKEM KKDDFMCDYC EETFSQTEEL EKHVMTRHPQ LSEKADLQCI
310 320 330 340 350
HCPEVFADES SLLTHIDQVH ANKKHKCPMC PEQFSSVEEV YCHLDSHRQP
360 370 380 390 400
DSSNHSISPD PVLGSVASMS SATPDSSASL ERASTPDSTL KPIRGHKQTG
410 420 430 440 450
SLEREEGQNW PKIAYSCPYC SKRDFNSLAV LEIHLKTIHV DKPQQNHTCQ
460 470 480 490 500
ICLDSLPTLY NLNEHVRKVH KNHAYPMVQF SNITAFHCNY CPEMFADINS
510 520 530 540 550
LQEHIRITHC GPNATPQEGN NAFFCNQCSM GFLTESSLTE HIQQTHCNVG
560 570 580 590 600
SSKLESPVIQ PTQSFMEVYS CPYCTNSPIF GSILKLTKHI KENHKNIPLA
610 620 630 640 650
NHKKSKSEQS PVSSDVEVSS PKRQRLCASL NSVSNGEYPC NQCDLKFSNF
660 670 680 690 700
DTFQTHLKSH LELLLRKQSC PQCKEDFDSQ ESLLQHLTIH YMTTSTHYVC
710 720 730 740 750
ESCDKQFSSV DDLQKHLLDM HTFVLYHCTL CQEVFDSKVS IQVHLAVKHS
760 770 780 790 800
NEKKMYRCTA CNWDFRREVD LQLHVKHSHL GNPSKSHKCI FCGETFSTEV
810 820 830 840 850
ELQCHITTHS KKYNCKFCSK AFHAIILLEK HLREKHCVFD TNNQNGTANG
860 870 880 890 900
MVPSNKKSES VEAQSGLMKN PDVTNSHDAS EDDVEASEPM YGCDICGAAY
910 920 930 940 950
TMEVLLQNHR LRDHNIRPGE DDGSRKKAEF IKGTHKCNIC SRTFFSENGL
960 970 980 990 1000
REHMQTHRGP AKHYMCPICG ERFPSLLTLT EHKVTHSKSL DTGTCRICKM
1010 1020 1030 1040 1050
PLQSEEEFIE HCQMHPDLRN SLTGFRCVVC MQTVTSTLEL KIHGTFHMQK
1060 1070 1080 1090 1100
LAGNSAASSP NGQTLQKMYK CAICLKEFRN KQDLVKLDVN GLPYGLCAGC
1110 1120 1130 1140 1150
LSRSTNGQPS NPTPQEACDR LCTSLRCSEC SVKFESTEDL ETHIQIDHRD
1160 1170 1180 1190 1200
LAHDGSGQRK VAQSSPVPRK KTYQCIKCQM TFENEREIQI HVANHMIEEG
1210 1220 1230 1240 1250
INHECKLCNQ MFDSPAKLLC HLIEHSFEGM GGTFKCPVCF TVFVQANKLQ
1260 1270 1280
QHIFAVHGQE DKIYDCSQCP QKFFFQTELQ NHTLSQHAQ
Length:1,289
Mass (Da):146,447
Last modified:November 24, 2009 - v1
Checksum:iFB18ECE34A9A8091
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ421283 mRNA. Translation: ACX34053.1.
RefSeqiNP_001159911.1. NM_001166439.1.
UniGeneiXl.47897.

Genome annotation databases

GeneIDi100310816.
KEGGixla:100310816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ421283 mRNA. Translation: ACX34053.1.
RefSeqiNP_001159911.1. NM_001166439.1.
UniGeneiXl.47897.

3D structure databases

ProteinModelPortaliD0E8G8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100310816.
KEGGixla:100310816.

Organism-specific databases

CTDi23090.
XenbaseiXB-GENE-6457352. znf423.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 30 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 28 hits.
PS50157. ZINC_FINGER_C2H2_2. 24 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression."
    Masserdotti G., Badaloni A., Green Y.S., Croci L., Barili V., Bergamini G., Vetter M.L., Consalez G.G.
    J. Biol. Chem. 285:30814-30824(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiD0E8G8_XENLA
AccessioniPrimary (citable) accession number: D0E8G8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: December 9, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.