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UniProtKB - D0E0C2 (SCNA1_PERAM)

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Protein

Sodium channel protein PaFPC1

Gene
N/A
Organism
Periplaneta americana (American cockroach) (Blatta americana)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywordsi

Molecular functionIon channel, Sodium channel, Voltage-gated channel
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein PaFPC11 Publication
Short name:
PaFPC11 Publication
Alternative name(s):
NavPaS1 Publication
OrganismiPeriplaneta americana (American cockroach) (Blatta americana)Imported
Taxonomic identifieri6978 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Polyneoptera › Dictyoptera › Blattodea › Blattoidea › Blattoidae › Blattidae › Blattinae › Periplaneta

Subcellular locationi

  • Cell membrane UniRule annotation1 Publication; Multi-pass membrane protein UniRule annotation1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 140CytoplasmicCombined sources1 PublicationAdd BLAST140
Transmembranei141 – 159Helical; Name=S1 of repeat ICombined sources1 PublicationAdd BLAST19
Topological domaini160 – 165ExtracellularCombined sources1 Publication6
Transmembranei166 – 186Helical; Name=S2 of repeat ICombined sources1 PublicationAdd BLAST21
Topological domaini187 – 200CytoplasmicCombined sources1 PublicationAdd BLAST14
Transmembranei201 – 218Helical; Name=S3 of repeat ICombined sources1 PublicationAdd BLAST18
Topological domaini219 – 224ExtracellularCombined sources1 Publication6
Transmembranei225 – 241Helical; Name=S4 of repeat ICombined sources1 PublicationAdd BLAST17
Topological domaini242 – 260CytoplasmicCombined sources1 PublicationAdd BLAST19
Transmembranei261 – 280Helical; Name=S5 of repeat ICombined sources1 PublicationAdd BLAST20
Topological domaini281 – 360ExtracellularCombined sources1 PublicationAdd BLAST80
Intramembranei361 – 385Pore-formingCombined sources1 PublicationAdd BLAST25
Topological domaini386 – 392ExtracellularCombined sources1 Publication7
Transmembranei393 – 413Helical; Name=S6 of repeat ICombined sources1 PublicationAdd BLAST21
Topological domaini414 – 519CytoplasmicCombined sources1 PublicationAdd BLAST106
Transmembranei520 – 538Helical; Name=S1 of repeat IICombined sources1 PublicationAdd BLAST19
Topological domaini539 – 549ExtracellularCombined sources1 PublicationAdd BLAST11
Transmembranei550 – 569Helical; Name=S2 of repeat IICombined sources1 PublicationAdd BLAST20
Topological domaini570 – 583CytoplasmicCombined sources1 PublicationAdd BLAST14
Transmembranei584 – 603Helical; Name=S3 of repeat IICombined sources1 PublicationAdd BLAST20
Topological domaini604 – 605ExtracellularCombined sources1 Publication2
Transmembranei606 – 623Helical; Name=S4 of repeat IICombined sources1 PublicationAdd BLAST18
Topological domaini624 – 639CytoplasmicCombined sources1 PublicationAdd BLAST16
Transmembranei640 – 658Helical; Name=S5 of repeat IICombined sources1 PublicationAdd BLAST19
Topological domaini659 – 686ExtracellularCombined sources1 PublicationAdd BLAST28
Intramembranei687 – 707Pore-formingCombined sources1 PublicationAdd BLAST21
Topological domaini708 – 719ExtracellularCombined sources1 PublicationAdd BLAST12
Transmembranei720 – 740Helical; Name=S6 of repeat IICombined sources1 PublicationAdd BLAST21
Topological domaini741 – 857CytoplasmicCombined sources1 PublicationAdd BLAST117
Transmembranei858 – 875Helical; Name=S1 of repeat IIICombined sources1 PublicationAdd BLAST18
Topological domaini876 – 888ExtracellularCombined sources1 PublicationAdd BLAST13
Transmembranei889 – 907Helical; Name=S2 of repeat IIICombined sources1 PublicationAdd BLAST19
Topological domaini908 – 921CytoplasmicCombined sources1 PublicationAdd BLAST14
Transmembranei922 – 940Helical; Name=S3 of repeat IIICombined sources1 PublicationAdd BLAST19
Topological domaini941 – 945ExtracellularCombined sources1 Publication5
Transmembranei946 – 964Helical; Name=S4 of repeat IIICombined sources1 PublicationAdd BLAST19
Topological domaini965 – 981CytoplasmicCombined sources1 PublicationAdd BLAST17
Transmembranei982 – 1001Helical; Name=S5 of repeat IIICombined sources1 PublicationAdd BLAST20
Topological domaini1002 – 1047ExtracellularCombined sources1 PublicationAdd BLAST46
Intramembranei1048 – 1069Pore-formingCombined sources1 PublicationAdd BLAST22
Topological domaini1070 – 1086ExtracellularCombined sources1 PublicationAdd BLAST17
Transmembranei1087 – 1108Helical; Name=S6 of repeat IIICombined sources1 PublicationAdd BLAST22
Topological domaini1109 – 1171CytoplasmicCombined sources1 PublicationAdd BLAST63
Transmembranei1172 – 1189Helical; Name=S1 of repeat IVCombined sources1 PublicationAdd BLAST18
Topological domaini1190 – 1200ExtracellularCombined sources1 PublicationAdd BLAST11
Transmembranei1201 – 1219Helical; Name=S2 of repeat IVCombined sources1 PublicationAdd BLAST19
Topological domaini1220 – 1231CytoplasmicCombined sources1 PublicationAdd BLAST12
Transmembranei1232 – 1249Helical; Name=S3 of repeat IVCombined sources1 PublicationAdd BLAST18
Topological domaini1250 – 1262ExtracellularCombined sources1 PublicationAdd BLAST13
Transmembranei1263 – 1279Helical; Name=S4 of repeat IVCombined sources1 PublicationAdd BLAST17
Topological domaini1280 – 1298CytoplasmicCombined sources1 PublicationAdd BLAST19
Transmembranei1299 – 1316Helical; Name=S5 of repeat IVCombined sources1 PublicationAdd BLAST18
Topological domaini1317 – 1338ExtracellularCombined sources1 PublicationAdd BLAST22
Intramembranei1339 – 1361Pore-formingCombined sources1 PublicationAdd BLAST23
Topological domaini1362 – 1387ExtracellularCombined sources1 PublicationAdd BLAST26
Transmembranei1388 – 1410Helical; Name=S6 of repeat IVCombined sources1 PublicationAdd BLAST23
Topological domaini1411 – 1553CytoplasmicCombined sources1 PublicationAdd BLAST143

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004397621 – 1553Sodium channel protein PaFPC1Add BLAST1553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi288 ↔ 337Combined sources1 Publication
Glycosylationi300N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi308N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi312N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi330N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi683N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi709 ↔ 717Combined sources1 Publication
Disulfide bondi1011 ↔ 1030Combined sources1 Publication
Glycosylationi1015N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi1028N-linked (GlcNAc...) asparagine; atypicalCombined sources1 Publication1
Glycosylationi1034N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi1301N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1368 ↔ 1381Combined sources1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Detected in adult nerve cord, muscle, gut and mushroom-shaped accessory glands.1 Publication

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5X0Melectron microscopy3.80A1-1553[»]
SMRiD0E0C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1133 – 1146Linker region that may regulate channel inactivation1 PublicationAdd BLAST14

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.1 Publication

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR001696. Na_channel_asu.
PfamiView protein in Pfam
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
PRINTSiPR00170. NACHANNEL.

Sequencei

Sequence statusi: Complete.

D0E0C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNSPLIRE ERQRLFRPYT RAMLTAPSAQ PAKENGKTEE NKDNSRDKGR 
        60         70         80         90        100
GANKDRDGSA HPDQALEQGS RLPARMRNIF PAELASTPLE DFDPFYKNKK 
       110        120        130        140        150
TFVVVTKAGD IFRFSGEKSL WMLDPFTPIR RVAISTMVQP IFSYFIMITI 
       160        170        180        190        200
LIHCIFMIMP ATQTTYILEL VFLSIYTIEV VVKVLARGFI LHPFAYLRDP 
       210        220        230        240        250
WNWLDFLVTL IGYITLVVDL GHLYALRAFR VLRSWRTVTI VPGWRTIVDA 
       260        270        280        290        300
LSLSITSLKD LVLLLLFSLF VFAVLGLQIY MGVLTQKCVK HFPADGSWGN 
       310        320        330        340        350
FTDERWFNYT SNSSHWYIPD DWIEYPLCGN SSGAGMCPPG YTCLQGYGGN 
       360        370        380        390        400
PNYGYTSFDT FGWAFLSVFR LVTLDYWEDL YQLALRSAGP WHILFFIIVV 
       410        420        430        440        450
FYGTFCFLNF ILAVVVMSYT HMVKRADEEK AAERELKKEK KAASVANNTA 
       460        470        480        490        500
NGQEQTTIEM NGDEAVVIDN NDQAARQQSD PETPAPSVTQ RLTDFLCVWD 
       510        520        530        540        550
CCVPWQKLQG AIGAVVLSPF FELFIAVIIV LNITFMALDH HDMNIEFERI 
       560        570        580        590        600
LRTGNYIFTS IYIVEAVLKI IALSPKFYFK DSWNVFDFII VVFAILELGL 
       610        620        630        640        650
EGVQGLSVFR SFRLLRVFRL AKFWPTLNNF MSVMTKSYGA FVNVMYVMFL 
       660        670        680        690        700
LLFIFAIIGM QLFGMNYIDN MERFPDGDLP RWNFTDFLHS FMIVFRALCG 
       710        720        730        740        750
EWIESMWDCM LVGDWSCIPF FVAVFFVGNL VILNLLIALL LNNYGSFCTS 
       760        770        780        790        800
PTSDEEDSKD EDALAQIVRI FKRFKPNLNA VKLSPMKPDS EDIVESQEIQ 
       810        820        830        840        850
GNNIADAEDV LAGEFPPDCC CNAFYKCFPS RPARDSSVQR MWSNIRRVCF 
       860        870        880        890        900
LLAKNKYFQK FVTAVLVITS VLLALEDIYL PQRPVLVNIT LYVDYVLTAF 
       910        920        930        940        950
FVIEMIIMLF AVGFKKYFTS KWYWLDFIVV VAYLLNFVLM CAGIEALQTL 
       960        970        980        990       1000
RLLRVFRLFR PLSKVNGMQV VTSTLVEAVP HIFNVILVGI FFWLVFAIMG 
      1010       1020       1030       1040       1050
VQLFAGKFYK CVDENSTVLS HEITMDRNDC LHENYTWENS PMNFDHVGNA 
      1060       1070       1080       1090       1100
YLSLLQVATF KGWLQIMNDA IDSREVHKQP IRETNIYMYL YFIFFIVFGS 
      1110       1120       1130       1140       1150
FFILKLFVCI LIDIFRQQRR KAEGLSATDS RTQLIYRRAV MRTMSAKPVK 
      1160       1170       1180       1190       1200
RIPKPTCHPQ SLMYDISVNR KFEYTMMILI ILNVAVMAID HYGQSMEFSE 
      1210       1220       1230       1240       1250
VLDYLNLIFI IIFFVECVIK VSGLRHHYFK DPWNIIDFLY VVLAIAGLML 
      1260       1270       1280       1290       1300
SDVIEKYFIS PTLLRILRIL RVGRLLRYFQ SARGMRLLLL ALRKALRTLF 
      1310       1320       1330       1340       1350
NVSFLLFVIM FVYAVFGMEF FMHIRDAGAI DDVYNFKTFG QSIILLFQLA 
      1360       1370       1380       1390       1400
TSAGWDGVYF AIANEEDCRA PDHELGYPGN CGSRALGIAY LVSYLIITCL 
      1410       1420       1430       1440       1450
VVINMYAAVI LDYVLEVYED SKEGLTDDDY DMFFEVWQQF DPEATQYIRY 
      1460       1470       1480       1490       1500
DQLSELLEAL QPPLQVQKPN KYKILSMNIP ICKDDHIFYK DVLEALVKDV 
      1510       1520       1530       1540       1550
FSRRGSPVEA GDVQAPNVDE AEYKPVSSTL QRQREEYCVR LIQNAWRKHK 

QQN
Length:1,553
Mass (Da):179,116
Last modified:November 24, 2009 - v1
Checksum:i62CBCDA0A59D61D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ132120 mRNA. Translation: ACX44802.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSCNA1_PERAM
AccessioniPrimary (citable) accession number: D0E0C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: November 24, 2009
Last modified: July 5, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families