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Protein

Sodium channel protein PaFPC1

Gene
N/A
Organism
Periplaneta americana (American cockroach) (Blatta americana)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channel, Voltage-gated channel
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein PaFPC11 Publication
Short name:
PaFPC11 Publication
Alternative name(s):
NavPaS1 Publication
OrganismiPeriplaneta americana (American cockroach) (Blatta americana)Imported
Taxonomic identifieri6978 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraPolyneopteraDictyopteraBlattodeaBlattoideaBlattoidaeBlattidaeBlattinaePeriplaneta

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 140CytoplasmicCombined sources1 PublicationAdd BLAST140
Transmembranei141 – 159Helical; Name=S1 of repeat ICombined sources1 PublicationAdd BLAST19
Topological domaini160 – 165ExtracellularCombined sources1 Publication6
Transmembranei166 – 186Helical; Name=S2 of repeat ICombined sources1 PublicationAdd BLAST21
Topological domaini187 – 200CytoplasmicCombined sources1 PublicationAdd BLAST14
Transmembranei201 – 218Helical; Name=S3 of repeat ICombined sources1 PublicationAdd BLAST18
Topological domaini219 – 224ExtracellularCombined sources1 Publication6
Transmembranei225 – 241Helical; Name=S4 of repeat ICombined sources1 PublicationAdd BLAST17
Topological domaini242 – 260CytoplasmicCombined sources1 PublicationAdd BLAST19
Transmembranei261 – 280Helical; Name=S5 of repeat ICombined sources1 PublicationAdd BLAST20
Topological domaini281 – 360ExtracellularCombined sources1 PublicationAdd BLAST80
Intramembranei361 – 385Pore-formingCombined sources1 PublicationAdd BLAST25
Topological domaini386 – 392ExtracellularCombined sources1 Publication7
Transmembranei393 – 413Helical; Name=S6 of repeat ICombined sources1 PublicationAdd BLAST21
Topological domaini414 – 519CytoplasmicCombined sources1 PublicationAdd BLAST106
Transmembranei520 – 538Helical; Name=S1 of repeat IICombined sources1 PublicationAdd BLAST19
Topological domaini539 – 549ExtracellularCombined sources1 PublicationAdd BLAST11
Transmembranei550 – 569Helical; Name=S2 of repeat IICombined sources1 PublicationAdd BLAST20
Topological domaini570 – 583CytoplasmicCombined sources1 PublicationAdd BLAST14
Transmembranei584 – 603Helical; Name=S3 of repeat IICombined sources1 PublicationAdd BLAST20
Topological domaini604 – 605ExtracellularCombined sources1 Publication2
Transmembranei606 – 623Helical; Name=S4 of repeat IICombined sources1 PublicationAdd BLAST18
Topological domaini624 – 639CytoplasmicCombined sources1 PublicationAdd BLAST16
Transmembranei640 – 658Helical; Name=S5 of repeat IICombined sources1 PublicationAdd BLAST19
Topological domaini659 – 686ExtracellularCombined sources1 PublicationAdd BLAST28
Intramembranei687 – 707Pore-formingCombined sources1 PublicationAdd BLAST21
Topological domaini708 – 719ExtracellularCombined sources1 PublicationAdd BLAST12
Transmembranei720 – 740Helical; Name=S6 of repeat IICombined sources1 PublicationAdd BLAST21
Topological domaini741 – 857CytoplasmicCombined sources1 PublicationAdd BLAST117
Transmembranei858 – 875Helical; Name=S1 of repeat IIICombined sources1 PublicationAdd BLAST18
Topological domaini876 – 888ExtracellularCombined sources1 PublicationAdd BLAST13
Transmembranei889 – 907Helical; Name=S2 of repeat IIICombined sources1 PublicationAdd BLAST19
Topological domaini908 – 921CytoplasmicCombined sources1 PublicationAdd BLAST14
Transmembranei922 – 940Helical; Name=S3 of repeat IIICombined sources1 PublicationAdd BLAST19
Topological domaini941 – 945ExtracellularCombined sources1 Publication5
Transmembranei946 – 964Helical; Name=S4 of repeat IIICombined sources1 PublicationAdd BLAST19
Topological domaini965 – 981CytoplasmicCombined sources1 PublicationAdd BLAST17
Transmembranei982 – 1001Helical; Name=S5 of repeat IIICombined sources1 PublicationAdd BLAST20
Topological domaini1002 – 1047ExtracellularCombined sources1 PublicationAdd BLAST46
Intramembranei1048 – 1069Pore-formingCombined sources1 PublicationAdd BLAST22
Topological domaini1070 – 1086ExtracellularCombined sources1 PublicationAdd BLAST17
Transmembranei1087 – 1108Helical; Name=S6 of repeat IIICombined sources1 PublicationAdd BLAST22
Topological domaini1109 – 1171CytoplasmicCombined sources1 PublicationAdd BLAST63
Transmembranei1172 – 1189Helical; Name=S1 of repeat IVCombined sources1 PublicationAdd BLAST18
Topological domaini1190 – 1200ExtracellularCombined sources1 PublicationAdd BLAST11
Transmembranei1201 – 1219Helical; Name=S2 of repeat IVCombined sources1 PublicationAdd BLAST19
Topological domaini1220 – 1231CytoplasmicCombined sources1 PublicationAdd BLAST12
Transmembranei1232 – 1249Helical; Name=S3 of repeat IVCombined sources1 PublicationAdd BLAST18
Topological domaini1250 – 1262ExtracellularCombined sources1 PublicationAdd BLAST13
Transmembranei1263 – 1279Helical; Name=S4 of repeat IVCombined sources1 PublicationAdd BLAST17
Topological domaini1280 – 1298CytoplasmicCombined sources1 PublicationAdd BLAST19
Transmembranei1299 – 1316Helical; Name=S5 of repeat IVCombined sources1 PublicationAdd BLAST18
Topological domaini1317 – 1338ExtracellularCombined sources1 PublicationAdd BLAST22
Intramembranei1339 – 1361Pore-formingCombined sources1 PublicationAdd BLAST23
Topological domaini1362 – 1387ExtracellularCombined sources1 PublicationAdd BLAST26
Transmembranei1388 – 1410Helical; Name=S6 of repeat IVCombined sources1 PublicationAdd BLAST23
Topological domaini1411 – 1553CytoplasmicCombined sources1 PublicationAdd BLAST143

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004397621 – 1553Sodium channel protein PaFPC1Add BLAST1553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi288 ↔ 337Combined sources1 Publication
Glycosylationi300N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi308N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi312N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi330N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi683N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi709 ↔ 717Combined sources1 Publication
Disulfide bondi1011 ↔ 1030Combined sources1 Publication
Glycosylationi1015N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi1028N-linked (GlcNAc...) asparagine; atypicalCombined sources1 Publication1
Glycosylationi1034N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi1301N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1368 ↔ 1381Combined sources1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

iPTMnetiD0E0C2.

Expressioni

Tissue specificityi

Detected in adult nerve cord, muscle, gut and mushroom-shaped accessory glands.1 Publication

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5X0Melectron microscopy3.80A1-1553[»]
SMRiD0E0C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1133 – 1146Linker region that may regulate channel inactivation1 PublicationAdd BLAST14

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.1 Publication

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiView protein in InterPro
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR001696. Na_channel_asu.
IPR027359. Volt_channel_dom_sf.
PfamiView protein in Pfam
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
PRINTSiPR00170. NACHANNEL.

Sequencei

Sequence statusi: Complete.

D0E0C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNSPLIRE ERQRLFRPYT RAMLTAPSAQ PAKENGKTEE NKDNSRDKGR
60 70 80 90 100
GANKDRDGSA HPDQALEQGS RLPARMRNIF PAELASTPLE DFDPFYKNKK
110 120 130 140 150
TFVVVTKAGD IFRFSGEKSL WMLDPFTPIR RVAISTMVQP IFSYFIMITI
160 170 180 190 200
LIHCIFMIMP ATQTTYILEL VFLSIYTIEV VVKVLARGFI LHPFAYLRDP
210 220 230 240 250
WNWLDFLVTL IGYITLVVDL GHLYALRAFR VLRSWRTVTI VPGWRTIVDA
260 270 280 290 300
LSLSITSLKD LVLLLLFSLF VFAVLGLQIY MGVLTQKCVK HFPADGSWGN
310 320 330 340 350
FTDERWFNYT SNSSHWYIPD DWIEYPLCGN SSGAGMCPPG YTCLQGYGGN
360 370 380 390 400
PNYGYTSFDT FGWAFLSVFR LVTLDYWEDL YQLALRSAGP WHILFFIIVV
410 420 430 440 450
FYGTFCFLNF ILAVVVMSYT HMVKRADEEK AAERELKKEK KAASVANNTA
460 470 480 490 500
NGQEQTTIEM NGDEAVVIDN NDQAARQQSD PETPAPSVTQ RLTDFLCVWD
510 520 530 540 550
CCVPWQKLQG AIGAVVLSPF FELFIAVIIV LNITFMALDH HDMNIEFERI
560 570 580 590 600
LRTGNYIFTS IYIVEAVLKI IALSPKFYFK DSWNVFDFII VVFAILELGL
610 620 630 640 650
EGVQGLSVFR SFRLLRVFRL AKFWPTLNNF MSVMTKSYGA FVNVMYVMFL
660 670 680 690 700
LLFIFAIIGM QLFGMNYIDN MERFPDGDLP RWNFTDFLHS FMIVFRALCG
710 720 730 740 750
EWIESMWDCM LVGDWSCIPF FVAVFFVGNL VILNLLIALL LNNYGSFCTS
760 770 780 790 800
PTSDEEDSKD EDALAQIVRI FKRFKPNLNA VKLSPMKPDS EDIVESQEIQ
810 820 830 840 850
GNNIADAEDV LAGEFPPDCC CNAFYKCFPS RPARDSSVQR MWSNIRRVCF
860 870 880 890 900
LLAKNKYFQK FVTAVLVITS VLLALEDIYL PQRPVLVNIT LYVDYVLTAF
910 920 930 940 950
FVIEMIIMLF AVGFKKYFTS KWYWLDFIVV VAYLLNFVLM CAGIEALQTL
960 970 980 990 1000
RLLRVFRLFR PLSKVNGMQV VTSTLVEAVP HIFNVILVGI FFWLVFAIMG
1010 1020 1030 1040 1050
VQLFAGKFYK CVDENSTVLS HEITMDRNDC LHENYTWENS PMNFDHVGNA
1060 1070 1080 1090 1100
YLSLLQVATF KGWLQIMNDA IDSREVHKQP IRETNIYMYL YFIFFIVFGS
1110 1120 1130 1140 1150
FFILKLFVCI LIDIFRQQRR KAEGLSATDS RTQLIYRRAV MRTMSAKPVK
1160 1170 1180 1190 1200
RIPKPTCHPQ SLMYDISVNR KFEYTMMILI ILNVAVMAID HYGQSMEFSE
1210 1220 1230 1240 1250
VLDYLNLIFI IIFFVECVIK VSGLRHHYFK DPWNIIDFLY VVLAIAGLML
1260 1270 1280 1290 1300
SDVIEKYFIS PTLLRILRIL RVGRLLRYFQ SARGMRLLLL ALRKALRTLF
1310 1320 1330 1340 1350
NVSFLLFVIM FVYAVFGMEF FMHIRDAGAI DDVYNFKTFG QSIILLFQLA
1360 1370 1380 1390 1400
TSAGWDGVYF AIANEEDCRA PDHELGYPGN CGSRALGIAY LVSYLIITCL
1410 1420 1430 1440 1450
VVINMYAAVI LDYVLEVYED SKEGLTDDDY DMFFEVWQQF DPEATQYIRY
1460 1470 1480 1490 1500
DQLSELLEAL QPPLQVQKPN KYKILSMNIP ICKDDHIFYK DVLEALVKDV
1510 1520 1530 1540 1550
FSRRGSPVEA GDVQAPNVDE AEYKPVSSTL QRQREEYCVR LIQNAWRKHK

QQN
Length:1,553
Mass (Da):179,116
Last modified:November 24, 2009 - v1
Checksum:i62CBCDA0A59D61D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ132120 mRNA. Translation: ACX44802.1.

Similar proteinsi

Entry informationi

Entry nameiSCNA1_PERAM
AccessioniPrimary (citable) accession number: D0E0C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: November 24, 2009
Last modified: February 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure