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D0CB74

- D0CB74_ACIBA

UniProt

D0CB74 - D0CB74_ACIBA

Protein

Riboflavin biosynthesis protein RibD

Gene

ribD

Organism
Acinetobacter baumannii ATCC 19606 = CIP 70.34
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.UniRule annotation

    Cofactori

    Binds 1 zinc ion.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541Zinc; via pros nitrogenImported
    Metal bindingi79 – 791ZincImported
    Metal bindingi88 – 881ZincImported
    Binding sitei154 – 1541Acetate

    GO - Molecular functioni

    1. 5-amino-6-(5-phosphoribosylamino)uracil reductase activity Source: InterPro
    2. diaminohydroxyphosphoribosylaminopyrimidine deaminase activity Source: InterPro
    3. NADP binding Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported, OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Riboflavin biosynthesisUniRule annotation

    Keywords - Ligandi

    Metal-bindingUniRule annotationImported, NADPUniRule annotation, ZincUniRule annotationImported

    Enzyme and pathway databases

    UniPathwayiUPA00275; UER00401.
    UPA00275; UER00402.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Riboflavin biosynthesis protein RibDUniRule annotation
    Gene namesi
    Name:ribDImported
    ORF Names:F911_03682Imported, HMPREF0010_02004Imported
    OrganismiAcinetobacter baumannii ATCC 19606 = CIP 70.34Imported
    Taxonomic identifieri575584 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZPCX-ray2.20A/B1-361[»]
    3ZPGX-ray1.99A1-361[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    In the C-terminal section; belongs to the HTP reductase family.UniRule annotation
    In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation

    Family and domain databases

    Gene3Di3.40.430.10. 1 hit.
    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR024072. DHFR-like_dom.
    IPR004794. Eubact_RibD.
    IPR011549. RibD_C.
    IPR002734. RibDG_C.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    PF01872. RibD_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006769. RibD. 1 hit.
    SUPFAMiSSF53597. SSF53597. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00326. eubact_ribD. 1 hit.
    TIGR00227. ribD_Cterm. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D0CB74-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSELKQDQYW MQQAIELAKR GLYSTKPNPN VGCVIVKDDQ LIGEGFHPKA    50
    GQPHAEVFAL RQAGEQAQGA TAYVTLEPCA HYGRTPPCAE ALVKAQVKKV 100
    VVACPDPNPL VAGKGVQILK NAGIEVEIGI CEDLAAKLNQ GFLKAMSTGM 150
    PYVRLKVASS LDGRTAMASG ESKWITGSAA RQDVQHWRAI SGAVITGIDT 200
    VIADDCQLNV RSLHNIDIET VAQPKRVILD RRGRLPLTAK ILENPETVMV 250
    MGPYRQELAD LGVIQLEIQP LKTLLQTLSK QYQIYDVLIE AGATLSSAFL 300
    QEGLIDEMIS YVAPTLLGQS ARAMFNADFE YMAQQLRFKL LDVIQLDQDI 350
    RLRLIPTQEK V 361
    Length:361
    Mass (Da):39,633
    Last modified:November 24, 2009 - v1
    Checksum:i13F6A01D4B132ACA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704574 Genomic DNA. Translation: EEX03756.1.
    APRG01000018 Genomic DNA. Translation: ENW73393.1.

    Genome annotation databases

    EnsemblBacteriaiEEX03756; EEX03756; HMPREF0010_02004.
    ENW73393; ENW73393; F911_03682.
    PATRICi24333545. VBIAciBau3967_1967.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704574 Genomic DNA. Translation: EEX03756.1 .
    APRG01000018 Genomic DNA. Translation: ENW73393.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZPC X-ray 2.20 A/B 1-361 [» ]
    3ZPG X-ray 1.99 A 1-361 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EEX03756 ; EEX03756 ; HMPREF0010_02004 .
    ENW73393 ; ENW73393 ; F911_03682 .
    PATRICi 24333545. VBIAciBau3967_1967.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00401 .
    UPA00275 ; UER00402 .

    Family and domain databases

    Gene3Di 3.40.430.10. 1 hit.
    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR024072. DHFR-like_dom.
    IPR004794. Eubact_RibD.
    IPR011549. RibD_C.
    IPR002734. RibDG_C.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    PF01872. RibD_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006769. RibD. 1 hit.
    SUPFAMi SSF53597. SSF53597. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00326. eubact_ribD. 1 hit.
    TIGR00227. ribD_Cterm. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC 19606Imported.
    2. "Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii."
      Dawson A., Trumper P., Chrysostomou G., Hunter W.N.
      Acta Crystallogr. F 69:611-617(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) IN COMPLEX WITH ZINC.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CIP 70.34Imported.

    Entry informationi

    Entry nameiD0CB74_ACIBA
    AccessioniPrimary (citable) accession number: D0CB74
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 24, 2009
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3