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D0CB74

- D0CB74_ACIBA

UniProt

D0CB74 - D0CB74_ACIBA

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Protein
Riboflavin biosynthesis protein RibD
Gene
ribD, F911_03682, HMPREF0010_02004
Organism
Acinetobacter baumannii ATCC 19606 = CIP 70.34
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate By similarity.UniRule annotation

Cofactori

Binds 1 zinc ion By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281Phosphate 1Imported
Binding sitei46 – 461Oxalic acid 1Imported
Metal bindingi54 – 541Zinc; via pros nitrogenImported
Binding sitei54 – 541Phosphate 1Imported
Binding sitei58 – 581Oxalic acid 1Imported
Metal bindingi79 – 791ZincImported
Binding sitei79 – 791Cacodylate; via amide nitrogenImported
Metal bindingi88 – 881ZincImported
Binding sitei154 – 1541Acetate
Binding sitei181 – 1811Phosphate 2Imported
Binding sitei188 – 1881Phosphate 2Imported
Binding sitei231 – 2311Oxalic acid 2Imported

GO - Molecular functioni

  1. 5-amino-6-(5-phosphoribosylamino)uracil reductase activity Source: InterPro
  2. NADP binding Source: InterPro
  3. diaminohydroxyphosphoribosylaminopyrimidine deaminase activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported, OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Riboflavin biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotationImported, NADPUniRule annotation, ZincUniRule annotationImported

Enzyme and pathway databases

UniPathwayiUPA00275; UER00401.
UPA00275; UER00402.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin biosynthesis protein RibDUniRule annotation
Gene namesi
Name:ribDImported
ORF Names:F911_03682Imported, HMPREF0010_02004Imported
OrganismiAcinetobacter baumannii ATCC 19606 = CIP 70.34Imported
Taxonomic identifieri575584 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZPCX-ray2.20A/B1-361[»]
3ZPGX-ray1.99A1-361[»]

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 563Cacodylate bindingImported
Regioni81 – 855Phosphate 1 bindingImported
Regioni207 – 2115Phosphate 2 bindingImported

Sequence similaritiesi

In the C-terminal section; belongs to the HTP reductase family.UniRule annotation
In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR024072. DHFR-like_dom.
IPR004794. Eubact_RibD.
IPR011549. RibD_C.
IPR002734. RibDG_C.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
PF01872. RibD_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006769. RibD. 1 hit.
SUPFAMiSSF53597. SSF53597. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00326. eubact_ribD. 1 hit.
TIGR00227. ribD_Cterm. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0CB74-1 [UniParc]FASTAAdd to Basket

« Hide

MSELKQDQYW MQQAIELAKR GLYSTKPNPN VGCVIVKDDQ LIGEGFHPKA    50
GQPHAEVFAL RQAGEQAQGA TAYVTLEPCA HYGRTPPCAE ALVKAQVKKV 100
VVACPDPNPL VAGKGVQILK NAGIEVEIGI CEDLAAKLNQ GFLKAMSTGM 150
PYVRLKVASS LDGRTAMASG ESKWITGSAA RQDVQHWRAI SGAVITGIDT 200
VIADDCQLNV RSLHNIDIET VAQPKRVILD RRGRLPLTAK ILENPETVMV 250
MGPYRQELAD LGVIQLEIQP LKTLLQTLSK QYQIYDVLIE AGATLSSAFL 300
QEGLIDEMIS YVAPTLLGQS ARAMFNADFE YMAQQLRFKL LDVIQLDQDI 350
RLRLIPTQEK V 361
Length:361
Mass (Da):39,633
Last modified:November 24, 2009 - v1
Checksum:i13F6A01D4B132ACA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704574 Genomic DNA. Translation: EEX03756.1.
APRG01000018 Genomic DNA. Translation: ENW73393.1.

Genome annotation databases

EnsemblBacteriaiEEX03756; EEX03756; HMPREF0010_02004.
ENW73393; ENW73393; F911_03682.
PATRICi24333545. VBIAciBau3967_1967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704574 Genomic DNA. Translation: EEX03756.1 .
APRG01000018 Genomic DNA. Translation: ENW73393.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZPC X-ray 2.20 A/B 1-361 [» ]
3ZPG X-ray 1.99 A 1-361 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EEX03756 ; EEX03756 ; HMPREF0010_02004 .
ENW73393 ; ENW73393 ; F911_03682 .
PATRICi 24333545. VBIAciBau3967_1967.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00401 .
UPA00275 ; UER00402 .

Family and domain databases

Gene3Di 3.40.430.10. 1 hit.
InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR024072. DHFR-like_dom.
IPR004794. Eubact_RibD.
IPR011549. RibD_C.
IPR002734. RibDG_C.
[Graphical view ]
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
PF01872. RibD_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006769. RibD. 1 hit.
SUPFAMi SSF53597. SSF53597. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00326. eubact_ribD. 1 hit.
TIGR00227. ribD_Cterm. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 19606Imported.
  2. "Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii."
    Dawson A., Trumper P., Chrysostomou G., Hunter W.N.
    Acta Crystallogr. F 69:611-617(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) IN COMPLEX WITH CACODYLATE; OXALIC ACID; PHOSPHATE AND ZINC.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CIP 70.34Imported.

Entry informationi

Entry nameiD0CB74_ACIBA
AccessioniPrimary (citable) accession number: D0CB74
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: September 3, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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