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D0B2M2

- D0B2M2_BRUME

UniProt

D0B2M2 - D0B2M2_BRUME

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Protein
NADH-quinone oxidoreductase subunit B
Gene
nuoB, BAWG_1052
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Iron-sulfur (4Fe-4S) By similarityUniRule annotation
Metal bindingi80 – 801Iron-sulfur (4Fe-4S) By similarityUniRule annotation
Metal bindingi144 – 1441Iron-sulfur (4Fe-4S) By similarityUniRule annotation
Metal bindingi174 – 1741Iron-sulfur (4Fe-4S) By similarityUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  3. iron ion binding Source: UniProtKB-HAMAP
  4. quinone binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

TransportUniRule annotation

Keywords - Ligandi

4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, NADUniRule annotation, UbiquinoneUniRule annotation

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-1192-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit BUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit B
NDH-1 subunit B
Gene namesi
Name:nuoBUniRule annotation
ORF Names:BAWG_1052Imported
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

PTM / Processingi

Keywords - PTMi

QuinoneUniRule annotation

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD0B2M2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0377.
KOiK00331.
OMAiNNSAEYV.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
HAMAPiMF_01356. NDH1_NuoB.
InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view]
PfamiPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
PROSITEiPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0B2M2-1 [UniParc]FASTAAdd to Basket

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MEEGGAGMGL TGTNTTLVAP QPKGILDPRT GKPVGSDDAF FNDLNGELSD    50
KGFIVTSADA LITWARTGSL MWMTFGLACC AVEMMHISMP RYDAERFGIA 100
PRASPRQSDV MIVAGTLTNK MAPALRKVYD QMPEPRYVIS MGSCANGGGY 150
YHYSYSVVRG CDRVVPVDIY VPGCPPTAEA LLYGILLLQK KIRRTGTIER 200
Length:200
Mass (Da):21,664
Last modified:November 24, 2009 - v1
Checksum:i65410FA2F51B8DC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG703778 Genomic DNA. Translation: EEW88944.1.
RefSeqiNP_540074.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiEEW88944; EEW88944; BAWG_1052.
GeneIDi1196868.
KEGGibme:BMEI1157.
PATRICi17797704. VBIBruMel146950_0667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG703778 Genomic DNA. Translation: EEW88944.1 .
RefSeqi NP_540074.1. NC_003317.1.

3D structure databases

ProteinModelPortali D0B2M2.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EEW88944 ; EEW88944 ; BAWG_1052 .
GeneIDi 1196868.
KEGGi bme:BMEI1157.
PATRICi 17797704. VBIBruMel146950_0667.

Phylogenomic databases

eggNOGi COG0377.
KOi K00331.
OMAi NNSAEYV.

Enzyme and pathway databases

BioCyci BMEL224914:GCJ0-1192-MONOMER.

Family and domain databases

Gene3Di 3.40.50.700. 1 hit.
HAMAPi MF_01356. NDH1_NuoB.
InterProi IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view ]
Pfami PF01058. Oxidored_q6. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01957. nuoB_fam. 1 hit.
PROSITEi PS01150. COMPLEX1_20K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 16MImported.

Entry informationi

Entry nameiD0B2M2_BRUME
AccessioniPrimary (citable) accession number: D0B2M2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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