D0AB36 (D0AB36_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
MHC class II antigen EMBL CBG98936.1

Gene names

Name:

HLA-DRB3 EMBL CBG98936.1

Organism

Homo sapiens (Human) EMBL CBG98936.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	183 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS003006

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC II RuleBase RU000321 SAAS SAAS003006 Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS014745
Technical term	3D-structure PDB 4H1L
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class II protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL CBG98936.1
	Non-terminal residue	183	1	EMBL CBG98936.1

Sequences

	Sequence		Length	Mass (Da)
	D0AB36 [UniParc]. Last modified November 24, 2009. Version 1. Checksum: 1D4F1E8D454E3E2E	FASTA	183	21,325
	10 20 30 40 50 60 RFLELLKSEC HFFNGTERVR FLERYFHNQE EFVRFDSDVG EYRAVTELGR PVAESWNSQK 70 80 90 100 110 120 DLLEQKRGRV DNYCRHNYGV GESFTVQRRV HPQVTVYPAK TQPLQHHNLL VCSVSGFYPG 130 140 150 160 170 180 SIEVRWFRNG QEEKTGVVST GLIHNGDWTF QTLVMLETVP RSGEVYTCQV EHPSVTSPLT VEW

References

[1]	"New sequences found during routine HLA typing, HLA-DRB3*0303 exon 2 and 3." Anholts J.D.H. Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Blood EMBL CBG98936.1.
[2]	"T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy." Yin L., Crawford F., Marrack P., Kappler J.W., Dai S. Proc. Natl. Acad. Sci. U.S.A. 109:18517-18522(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

FN556017 Genomic DNA. Translation: CBG98936.1.

IPI

IPI00553012.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4H1L	X-ray	3.30	B/E	1-183	[»]

ModBase

Search...

Proteomic databases

PRIDE

D0AB36.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Gene expression databases

ArrayExpress

D0AB36.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.10.320.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]

ProDom

PD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

35488897.

Entry information

Entry name

D0AB36_HUMAN

Accession

Primary (citable) accession number: D0AB36

Entry history

Integrated into UniProtKB/TrEMBL:	November 24, 2009
Last sequence update:	November 24, 2009
Last modified:	May 29, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.