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Protein

Phosphoglycerate kinase

Gene

TbgDal_I140

Organism
Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (TbgDal_VI4080), Glyceraldehyde-3-phosphate dehydrogenase (TbgDal_X8410)
  2. Phosphoglycerate kinase (TbgDal_I140), Phosphoglycerate kinase (TbgDal_I150), Phosphoglycerate kinase (TbgDal_XI2630), Phosphoglycerate kinase (TbgDal_I160)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Pyruvate kinase (TbgDal_X16510), Pyruvate kinase (TbgDal_X16520)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Binding sitei172SubstrateUniRule annotation1
Binding sitei223ATPUniRule annotation1
Binding sitei345ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 378ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
ORF Names:TbgDal_I140Imported
OrganismiTrypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)Imported
Taxonomic identifieri679716 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
Proteomesi
  • UP000002316 Componenti: Chromosome 1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingUniRule annotation3
Regioni62 – 65Substrate bindingUniRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili258 – 278Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 2 hits.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiView protein in InterPro
IPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
IPR036043. Phosphoglycerate_kinase_sf.
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiView protein in Pfam
PF00162. PGK. 1 hit.
PIRSFiPIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiView protein in PROSITE
PS00111. PGLYCERATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

C9ZHU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNEKKSIN ECDLKGKKVL IRVDFNVPVK NGKITNDYRI RSALPTLKKV
60 70 80 90 100
LTEGGSCVLM SHLGRPKGIP MAQADKIRST GGVPGFQQKA TLKPVAKRLS
110 120 130 140 150
ELLLRPVTFA PDCLNAADVV SKMSPGDVVL LENVRFYKEE GSKKAKDREA
160 170 180 190 200
MAKILASYGD VYISDAFGTA HRDSATMTGI PKILGNGAAG YLMEKEISYF
210 220 230 240 250
AKVLGNPPRP LVAIVGGAKV SDKIQLLDNM LQRIDYLLIG GAMAYTFLKA
260 270 280 290 300
QGYSIGKSKC EESKLEFARS LLKKAEDRKV QIILPIDHVC HTEFKAVDSP
310 320 330 340 350
LITEDQNIPE GHMALDIGPK TIEKYVQTIG KCKSAIWNGP MGVFEMVPYS
360 370 380 390 400
KGTFAIAKAM GRGTHEHGLM SIIGGGDSAS AAELSGEAKR MSHVSTGGGA
410 420 430 440
SLELLEGKTL PGVAVLDEKS AVVSYASAGT GTLSNRWSSL
Length:440
Mass (Da):47,246
Last modified:November 24, 2009 - v1
Checksum:i602AC07F503FBDB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554964 Genomic DNA. Translation: CBH08819.1.
RefSeqiXP_011771260.1. XM_011772958.1.

Genome annotation databases

GeneIDi23858193.

Similar proteinsi

Entry informationi

Entry nameiC9ZHU8_TRYB9
AccessioniPrimary (citable) accession number: C9ZHU8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: December 20, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported