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C9ZCP3

- C9ZCP3_STRSW

UniProt

C9ZCP3 - C9ZCP3_STRSW

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Protein

Probable DNA ligase

Gene
lig, SCAB_78681
Organism
Streptomyces scabies (strain 87.22) (Streptomyces scabiei)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081ATP By similarityUniRule annotation
Active sitei210 – 2101N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei215 – 2151ATP By similarityUniRule annotation
Binding sitei230 – 2301ATP By similarityUniRule annotation
Binding sitei259 – 2591ATP By similarityUniRule annotation
Binding sitei299 – 2991ATP By similarityUniRule annotation
Binding sitei374 – 3741ATP By similarityUniRule annotation
Binding sitei380 – 3801ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSCA680198:GJ76-7705-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:SCAB_78681Imported
OrganismiStreptomyces scabies (strain 87.22) (Streptomyces scabiei)Imported
Taxonomic identifieri680198 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000001444: Chromosome

Structurei

3D structure databases

ProteinModelPortaliC9ZCP3.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK01971.
OMAiVPIVIPY.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9ZCP3-1 [UniParc]FASTAAdd to Basket

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MLFARLARVS QEIAATSARS RKTALLADLF RDAGEEDVPI VIPYLAGRLP    50
QGRLGIGWKV LDQRIPPAGT ATLTVREVDA RLTAIGAVTG TGSQTERRRL 100
VGALLAAATE DEQRYLVGLL TGEVRQGALD ALAVEGLAGA TGAPAADVRR 150
AVMLAGSLQT VARALLAEGP RALEGFRLTV GRPVQPMLAH SAPSVAEAVA 200
KLGVCAVEEK LDGIRVQLHR DGGDVRLYTR TLDDITDRLP ELTSAALGLR 250
GERFILDGEV IAFDGNGRPR SFQETAGRVG SRLDVATAAR QVPVSPVFFD 300
ALSVDGQDLL DLPFTERHAV LARLVPEPMR VRRTLVTGPD DLPEAERFLT 350
DTLERGHEGV VLKALDAPYS AGRRGASWLK VKPVHTLDLV VLAAEWGHGR 400
RTGRLSNLHL GARTADGAFA MLGKTFKGMT DALLAWQTER LTELAVEEHR 450
WGVTVRPELV VEIAYDGLQR STRYPAGVTL RFARVIRYRE DKTPGEADTV 500
EALLSAHPEV TR 512
Length:512
Mass (Da):55,286
Last modified:November 24, 2009 - v1
Checksum:iEF258D84F913D2FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN554889 Genomic DNA. Translation: CBG74832.1.
RefSeqiYP_003493363.1. NC_013929.1.

Genome annotation databases

EnsemblBacteriaiCBG74832; CBG74832; SCAB_78681.
GeneIDi8844530.
KEGGiscb:SCAB_78681.
PATRICi35331449. VBIStrSca144334_7758.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN554889 Genomic DNA. Translation: CBG74832.1 .
RefSeqi YP_003493363.1. NC_013929.1.

3D structure databases

ProteinModelPortali C9ZCP3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBG74832 ; CBG74832 ; SCAB_78681 .
GeneIDi 8844530.
KEGGi scb:SCAB_78681.
PATRICi 35331449. VBIStrSca144334_7758.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K01971.
OMAi VPIVIPY.

Enzyme and pathway databases

BioCyci SSCA680198:GJ76-7705-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions."
    Bignell D.R., Seipke R.F., Huguet-Tapia J.C., Chambers A.H., Parry R.J., Loria R.
    Mol. Plant Microbe Interact. 23:161-175(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 87.22Imported.

Entry informationi

Entry nameiC9ZCP3_STRSW
AccessioniPrimary (citable) accession number: C9ZCP3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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