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C9ZCP3

- C9ZCP3_STRSW

UniProt

C9ZCP3 - C9ZCP3_STRSW

Protein

Probable DNA ligase

Gene

lig

Organism
Streptomyces scabies (strain 87.22) (Streptomyces scabiei)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei208 – 2081ATPUniRule annotation
    Active sitei210 – 2101N6-AMP-lysine intermediateUniRule annotation
    Binding sitei215 – 2151ATPUniRule annotation
    Binding sitei230 – 2301ATPUniRule annotation
    Binding sitei259 – 2591ATPUniRule annotation
    Binding sitei299 – 2991ATPUniRule annotation
    Binding sitei374 – 3741ATPUniRule annotation
    Binding sitei380 – 3801ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSCA680198:GJ76-7705-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:SCAB_78681Imported
    OrganismiStreptomyces scabies (strain 87.22) (Streptomyces scabiei)Imported
    Taxonomic identifieri680198 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000001444: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliC9ZCP3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK01971.
    OMAiVPIVIPY.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C9ZCP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFARLARVS QEIAATSARS RKTALLADLF RDAGEEDVPI VIPYLAGRLP    50
    QGRLGIGWKV LDQRIPPAGT ATLTVREVDA RLTAIGAVTG TGSQTERRRL 100
    VGALLAAATE DEQRYLVGLL TGEVRQGALD ALAVEGLAGA TGAPAADVRR 150
    AVMLAGSLQT VARALLAEGP RALEGFRLTV GRPVQPMLAH SAPSVAEAVA 200
    KLGVCAVEEK LDGIRVQLHR DGGDVRLYTR TLDDITDRLP ELTSAALGLR 250
    GERFILDGEV IAFDGNGRPR SFQETAGRVG SRLDVATAAR QVPVSPVFFD 300
    ALSVDGQDLL DLPFTERHAV LARLVPEPMR VRRTLVTGPD DLPEAERFLT 350
    DTLERGHEGV VLKALDAPYS AGRRGASWLK VKPVHTLDLV VLAAEWGHGR 400
    RTGRLSNLHL GARTADGAFA MLGKTFKGMT DALLAWQTER LTELAVEEHR 450
    WGVTVRPELV VEIAYDGLQR STRYPAGVTL RFARVIRYRE DKTPGEADTV 500
    EALLSAHPEV TR 512
    Length:512
    Mass (Da):55,286
    Last modified:November 24, 2009 - v1
    Checksum:iEF258D84F913D2FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN554889 Genomic DNA. Translation: CBG74832.1.
    RefSeqiYP_003493363.1. NC_013929.1.

    Genome annotation databases

    EnsemblBacteriaiCBG74832; CBG74832; SCAB_78681.
    GeneIDi8844530.
    KEGGiscb:SCAB_78681.
    PATRICi35331449. VBIStrSca144334_7758.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN554889 Genomic DNA. Translation: CBG74832.1 .
    RefSeqi YP_003493363.1. NC_013929.1.

    3D structure databases

    ProteinModelPortali C9ZCP3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBG74832 ; CBG74832 ; SCAB_78681 .
    GeneIDi 8844530.
    KEGGi scb:SCAB_78681.
    PATRICi 35331449. VBIStrSca144334_7758.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K01971.
    OMAi VPIVIPY.

    Enzyme and pathway databases

    BioCyci SSCA680198:GJ76-7705-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions."
      Bignell D.R., Seipke R.F., Huguet-Tapia J.C., Chambers A.H., Parry R.J., Loria R.
      Mol. Plant Microbe Interact. 23:161-175(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 87.22Imported.

    Entry informationi

    Entry nameiC9ZCP3_STRSW
    AccessioniPrimary (citable) accession number: C9ZCP3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 24, 2009
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3