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Protein

Probable DNA ligase

Gene

lig

Organism
Streptomyces scabies (strain 87.22) (Streptomyces scabiei)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081ATPUniRule annotation
Active sitei210 – 2101N6-AMP-lysine intermediateUniRule annotation
Binding sitei215 – 2151ATPUniRule annotation
Binding sitei230 – 2301ATPUniRule annotation
Binding sitei259 – 2591ATPUniRule annotation
Binding sitei299 – 2991ATPUniRule annotation
Binding sitei374 – 3741ATPUniRule annotation
Binding sitei380 – 3801ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSCA680198:GJ76-7705-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:SCAB_78681Imported
OrganismiStreptomyces scabies (strain 87.22) (Streptomyces scabiei)Imported
Taxonomic identifieri680198 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
ProteomesiUP000001444 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi680198.SCAB_78681.

Structurei

3D structure databases

ProteinModelPortaliC9ZCP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9ZCP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFARLARVS QEIAATSARS RKTALLADLF RDAGEEDVPI VIPYLAGRLP
60 70 80 90 100
QGRLGIGWKV LDQRIPPAGT ATLTVREVDA RLTAIGAVTG TGSQTERRRL
110 120 130 140 150
VGALLAAATE DEQRYLVGLL TGEVRQGALD ALAVEGLAGA TGAPAADVRR
160 170 180 190 200
AVMLAGSLQT VARALLAEGP RALEGFRLTV GRPVQPMLAH SAPSVAEAVA
210 220 230 240 250
KLGVCAVEEK LDGIRVQLHR DGGDVRLYTR TLDDITDRLP ELTSAALGLR
260 270 280 290 300
GERFILDGEV IAFDGNGRPR SFQETAGRVG SRLDVATAAR QVPVSPVFFD
310 320 330 340 350
ALSVDGQDLL DLPFTERHAV LARLVPEPMR VRRTLVTGPD DLPEAERFLT
360 370 380 390 400
DTLERGHEGV VLKALDAPYS AGRRGASWLK VKPVHTLDLV VLAAEWGHGR
410 420 430 440 450
RTGRLSNLHL GARTADGAFA MLGKTFKGMT DALLAWQTER LTELAVEEHR
460 470 480 490 500
WGVTVRPELV VEIAYDGLQR STRYPAGVTL RFARVIRYRE DKTPGEADTV
510
EALLSAHPEV TR
Length:512
Mass (Da):55,286
Last modified:November 24, 2009 - v1
Checksum:iEF258D84F913D2FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554889 Genomic DNA. Translation: CBG74832.1.
RefSeqiWP_013005283.1. NC_013929.1.
YP_003493363.1. NC_013929.1.

Genome annotation databases

EnsemblBacteriaiCBG74832; CBG74832; SCAB_78681.
KEGGiscb:SCAB_78681.
PATRICi35331449. VBIStrSca144334_7758.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554889 Genomic DNA. Translation: CBG74832.1.
RefSeqiWP_013005283.1. NC_013929.1.
YP_003493363.1. NC_013929.1.

3D structure databases

ProteinModelPortaliC9ZCP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi680198.SCAB_78681.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBG74832; CBG74832; SCAB_78681.
KEGGiscb:SCAB_78681.
PATRICi35331449. VBIStrSca144334_7758.

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Enzyme and pathway databases

BioCyciSSCA680198:GJ76-7705-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions."
    Bignell D.R., Seipke R.F., Huguet-Tapia J.C., Chambers A.H., Parry R.J., Loria R.
    Mol. Plant Microbe Interact. 23:161-175(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 87.22Imported.

Entry informationi

Entry nameiC9ZCP3_STRSW
AccessioniPrimary (citable) accession number: C9ZCP3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 24, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.