Skip Header

Contribute Send feedback
Read comments (?) or add your own

C9ZBH3 (C9ZBH3_STRSW) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800
Gene names
Ordered Locus Names:SCAB_15241
OrganismStreptomyces scabies (strain 87.22) (Streptomyces scabiei) [Complete proteome] [HAMAP]
Taxonomic identifier680198 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces ›

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
C9ZBH3 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 72647377DB02A4E1

FASTA42947,140
        10         20         30         40         50         60 
MLARSTASEA EAHQLDEALP GLRELFHIPP ADGGRYTETA YLAGNSLGLQ PKATLAELTE 

        70         80         90        100        110        120 
DLSDWSRFGV EGHHDAVRPW FGYHRLLTEP AARLVGALPE ETVVMNSLTV NLHLLMVSFY 

       130        140        150        160        170        180 
RPQGERTQIV IEDSAFPSDS YAVRSHVRFR GLDPDQAVTR LRPRPGEDCL RTEDVVDFLD 

       190        200        210        220        230        240 
RHGHTVALML LGGVNYLTGE LMDVPAITAA GHAAGATVGW DLAHAAGNVP LHLHNWDVDF 

       250        260        270        280        290        300 
AAWCSYKYLN SGPGALSGVF IHQRHVTDRG LQRLEGWWST DAATRFRMEP VSQPPATADA 

       310        320        330        340        350        360 
WAISNPPILA MGPVRTSLEL FDAVGMAALR ARSEKLTGYL EGLLDAITHT RPLTVITPRD 

       370        380        390        400        410        420 
TQRRGAQLSL RVGRTSAAAL ARKLRHEHGV VADAREPDII RLAPVPLYST FHDCWRAADA 


LAHCVPEER

« Hide

References

[1]"The first genome sequence of a pathogenic streptomycete, Streptomyces scabies."
Yaxley A., Bentley S.D., Loria R.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 87.22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN554889 Genomic DNA. Translation: CBG68668.1.
RefSeqYP_003487233.1. NC_013929.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBG68668; CBG68668; SCAB_15241.
GeneID8838532.
KEGGscb:SCAB_15241.
PATRIC35318748. VBIStrSca144334_1489.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000242438.
KOK01556.
OMAMVSFYRP.

Enzyme and pathway databases

UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC9ZBH3_STRSW
AccessionPrimary (citable) accession number: C9ZBH3
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info