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C9Z8S2 (C9Z8S2_STRSW) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methionine--tRNA ligase HAMAP-Rule MF_00098
EC=6.1.1.10 HAMAP-Rule MF_00098
Alternative name(s):
Methionyl-tRNA synthetase HAMAP-Rule MF_00098
Gene names
Name:metG HAMAP-Rule MF_00098 EMBL CBG71547.1
Ordered Locus Names:SCAB_44841
OrganismStreptomyces scabies (strain 87.22) (Streptomyces scabiei) [Complete proteome] [HAMAP]
Taxonomic identifier680198 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces ›

Protein attributes

Sequence length577 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation By similarity. HAMAP-Rule MF_00098

Catalytic activity

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). HAMAP-Rule MF_00098 SAAS SAAS023458

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00098

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00098

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00098.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. HAMAP-Rule MF_00098

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Motif11 – 2111"HIGH" region By similarity HAMAP-Rule MF_00098
Motif347 – 3515"KMSKS" region By similarity HAMAP-Rule MF_00098

Sites

Metal binding1431Zinc By similarity HAMAP-Rule MF_00098
Metal binding1461Zinc By similarity HAMAP-Rule MF_00098
Metal binding1561Zinc By similarity HAMAP-Rule MF_00098
Metal binding1591Zinc By similarity HAMAP-Rule MF_00098
Binding site3501ATP By similarity HAMAP-Rule MF_00098

Sequences

Sequence LengthMass (Da)Tools
C9Z8S2 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 81DFFD9A6CB79EF5

FASTA57764,964
        10         20         30         40         50         60 
MARHLITSAL PYINGIKHLG NMVGSMLPAD VYSRYLRQRG HDVLYICATD EHGTPAELAA 

        70         80         90        100        110        120 
KERGLPVDEF CAQAHDAQKA VYDGFALAFD YFGRSSSPQN VEITQHFARR LKENGFIEER 

       130        140        150        160        170        180 
AIRQVYSPAD GRFLPDRYVE GTCPHCGYDK ARGDQCENCT RVLDPTDLID PRSAISGSTD 

       190        200        210        220        230        240 
LEVRETKHLF LLQSKLQHEV EAWVAAHEEE WPHLSSSIAR KWLNEGLHDR AITRDLDWGV 

       250        260        270        280        290        300 
PVPADTWPEL AAEGKVFYVW FDAPIEYIGA TKEWSDAAPD GEKRDWKSWW YEADGGDHPV 

       310        320        330        340        350        360 
RYTQFMAKDN VPFHTVMFPA TELGIREPWK KVDYVKSFNW LTYYGGKFST SQKRGVFTDQ 

       370        380        390        400        410        420 
ALEILPADYW RYFLIANAPE SDDSSFTWEH FTATVNKDLA DTLGNFVNRV LSFSRKRFGD 

       430        440        450        460        470        480 
EVPAGAAAGE AETRLGEEIA RLLAEYEAQM EALQFRKAAA ALRALWSAGN SYLEEKAPWL 

       490        500        510        520        530        540 
EIKTDQDAAA LTLRTAMNLI HLYSVVSEPF IPASSAAMRA AFALKDDTAA WVTAEEARAL 

       550        560        570 
AFVPAGTPFT VPPVLFAKLT DDDLETYKER FGGTPEQ

« Hide

References

[1]"The first genome sequence of a pathogenic streptomycete, Streptomyces scabies."
Yaxley A., Bentley S.D., Loria R.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 87.22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN554889 Genomic DNA. Translation: CBG71547.1.
RefSeqYP_003490092.1. NC_013929.1.

3D structure databases

ProteinModelPortalC9Z8S2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBG71547; CBG71547; SCAB_44841.
GeneID8841326.
KEGGscb:SCAB_44841.
PATRIC35324618. VBIStrSca144334_4400.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000200402.
KOK01874.
OMALTQHFAG.

Family and domain databases

Gene3D3.40.50.620. 2 hits.
HAMAPMF_00098. Met_tRNA_synth_type1.
InterProIPR023458. Met-tRNA_ligase_1.
IPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamPF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR01041. TRNASYNTHMET.
SUPFAMSSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMsTIGR00398. metG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC9Z8S2_STRSW
AccessionPrimary (citable) accession number: C9Z8S2
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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