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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Streptomyces scabies (strain 87.22) (Streptomyces scabiei)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. aspartate carbamoyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  3. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciSSCA680198:GJ76-7368-MONOMER.
UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotationImported
Ordered Locus Names:SCAB_75191Imported
OrganismiStreptomyces scabies (strain 87.22) (Streptomyces scabiei)Imported
Taxonomic identifieri680198 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000001444: Chromosome

Structurei

3D structure databases

ProteinModelPortaliC9Z7J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000022685.
KOiK00609.
OMAiHEHPSQG.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9Z7J9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRHLISAAD LTRDDAVLIL DTAEEMARVA DRPIKKLPTL RGRTIVNLFF
60 70 80 90 100
EDSTRTRISF EAAEKRLSAD VINFTAKGSS VSKGESLKDT AQTLEAMGVD
110 120 130 140 150
AVVIRHGASG APYRLATSGW IDAAVINAGD GTHQHPTQAL LDAFTMRRRL
160 170 180 190 200
VGRDAGLGQD LSGKRITLVG DVLHSRVARS NVDLLHTLGA QVTLVAPPTL
210 220 230 240 250
VPVGVHTWPC EVSYDLDSTL AKSDAVMMLR VQRERMNAAF FPTEREYSRR
260 270 280 290 300
YGLDGDRMAR MPEHAIVMHP GPMVRGMEIT AEVADSDRCT VVEQVANGVS
310 320
IRMAVLYLLL GGNEPAVTHT RTTEEK
Length:326
Mass (Da):35,623
Last modified:November 24, 2009 - v1
Checksum:i7C9CF3AA3D4FD41A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554889 Genomic DNA. Translation: CBG74499.1.
RefSeqiWP_013005033.1. NC_013929.1.
YP_003493033.1. NC_013929.1.

Genome annotation databases

EnsemblBacteriaiCBG74499; CBG74499; SCAB_75191.
GeneIDi8846495.
KEGGiscb:SCAB_75191.
PATRICi35330755. VBIStrSca144334_7414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554889 Genomic DNA. Translation: CBG74499.1.
RefSeqiWP_013005033.1. NC_013929.1.
YP_003493033.1. NC_013929.1.

3D structure databases

ProteinModelPortaliC9Z7J9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBG74499; CBG74499; SCAB_75191.
GeneIDi8846495.
KEGGiscb:SCAB_75191.
PATRICi35330755. VBIStrSca144334_7414.

Phylogenomic databases

HOGENOMiHOG000022685.
KOiK00609.
OMAiHEHPSQG.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116.
BioCyciSSCA680198:GJ76-7368-MONOMER.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions."
    Bignell D.R., Seipke R.F., Huguet-Tapia J.C., Chambers A.H., Parry R.J., Loria R.
    Mol. Plant Microbe Interact. 23:161-175(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 87.22Imported.

Entry informationi

Entry nameiC9Z7J9_STRSW
AccessioniPrimary (citable) accession number: C9Z7J9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: February 4, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.