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C9Z4D0

- PSB_STRSW

UniProt

C9Z4D0 - PSB_STRSW

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Protein

Proteasome subunit beta

Gene
prcB, SCAB_73471
Organism
Streptomyces scabies (strain 87.22) (Streptomyces scabiei)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation By similarity.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541Nucleophile By similarity

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. modification-dependent protein catabolic process Source: UniProtKB-HAMAP
  2. proteasomal protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciSSCA680198:GJ76-7194-MONOMER.
UniPathwayiUPA00997.

Protein family/group databases

MEROPSiT01.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta (EC:3.4.25.1)
Alternative name(s):
20S proteasome beta subunit
Proteasome core protein PrcB
Gene namesi
Name:prcB
Ordered Locus Names:SCAB_73471
OrganismiStreptomyces scabies (strain 87.22) (Streptomyces scabiei)
Taxonomic identifieri680198 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000001444: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. proteasome core complex, beta-subunit complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 5353Removed in mature form; by autocatalysis By similarityPRO_0000397590Add
BLAST
Chaini54 – 281228Proteasome subunit betaUniRule annotationPRO_0000397591Add
BLAST

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.

Phylogenomic databases

HOGENOMiHOG000245308.
KOiK03433.
OMAiFQVELEH.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02113_B. Proteasome_B_B.
InterProiIPR029055. Ntn_hydrolases_N.
IPR022483. Pept_T1A_Psome_suB_actinobac.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03690. 20S_bact_beta. 1 hit.
PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C9Z4D0-1 [UniParc]FASTAAdd to Basket

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MEANTRSTGR LPAAFLTPGS SSFMDFLSDH QPELLPGKRQ LPPTQGVIEA    50
PHGTTIVAVT FPGGVVLAGD RRATMGNMIA QRDIEKVFPA DEYSAVGIAG 100
TAGLAVEMVK LFQLELEHFE KVEGAQLSLE GKANRLSTMI RSNLGMAMQG 150
LAVVPLFAGY DVDRNRGRIF SYDVTGGRSE ESGYAATGSG SIFARGAMKK 200
LFRADLSEAD ATTLVVQALY DAADDDSATG GPDVARRIYP IVTVITEDGF 250
RRLTDEESSE IARSILERRL EQPDGPRAAL L 281
Length:281
Mass (Da):30,140
Last modified:November 24, 2009 - v1
Checksum:iA3D3C0548E6BDF6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN554889 Genomic DNA. Translation: CBG74332.1.
RefSeqiYP_003492866.1. NC_013929.1.

Genome annotation databases

EnsemblBacteriaiCBG74332; CBG74332; SCAB_73471.
GeneIDi8844069.
KEGGiscb:SCAB_73471.
PATRICi35330399. VBIStrSca144334_7243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN554889 Genomic DNA. Translation: CBG74332.1 .
RefSeqi YP_003492866.1. NC_013929.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi T01.005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBG74332 ; CBG74332 ; SCAB_73471 .
GeneIDi 8844069.
KEGGi scb:SCAB_73471.
PATRICi 35330399. VBIStrSca144334_7243.

Phylogenomic databases

HOGENOMi HOG000245308.
KOi K03433.
OMAi FQVELEH.

Enzyme and pathway databases

UniPathwayi UPA00997 .
BioCyci SSCA680198:GJ76-7194-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_02113_B. Proteasome_B_B.
InterProi IPR029055. Ntn_hydrolases_N.
IPR022483. Pept_T1A_Psome_suB_actinobac.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR03690. 20S_bact_beta. 1 hit.
PROSITEi PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions."
    Bignell D.R., Seipke R.F., Huguet-Tapia J.C., Chambers A.H., Parry R.J., Loria R.
    Mol. Plant Microbe Interact. 23:161-175(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 87.22.

Entry informationi

Entry nameiPSB_STRSW
AccessioniPrimary (citable) accession number: C9Z4D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi