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Protein

Kynureninase

Gene

kynU

Organism
Streptomyces scabiei (strain 87.22)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (kynU), Kynureninase (kynU)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (kynU), Kynureninase (kynU)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (nbaC)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei83Pyridoxal phosphateUniRule annotation1
Binding sitei187Pyridoxal phosphateUniRule annotation1
Binding sitei190Pyridoxal phosphateUniRule annotation1
Binding sitei212Pyridoxal phosphateUniRule annotation1
Binding sitei242Pyridoxal phosphateUniRule annotation1
Binding sitei268Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseImported, HydrolaseUniRule annotation, Transferase
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:SCAB_42121Imported
OrganismiStreptomyces scabiei (strain 87.22)Imported
Taxonomic identifieri680198 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001444 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei213N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi680198.SCAB_42121.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 286Aminotran_5InterPro annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni118 – 121Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKY. Bacteria.
COG3844. LUCA.
HOGENOMiHOG000242437.
KOiK01556.
OMAiGWYGGDK.
OrthoDBiPOG091H0D63.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase. 1 hit.
InterProiView protein in InterPro
IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiView protein in Pfam
PF00266. Aminotran_5. 1 hit.
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

C9Z429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSGLRSRFV LDDAVYLDGN SLGALPASVP GRLTDVVHRE WGEMRIRSWD
60 70 80 90 100
ESGWWTAPER IGDRIAPLVG AAPGQIVVGD STSVNVFKAV VAAVRMAEED
110 120 130 140 150
SASAGGRRDE ILVDATTFPT DGYMAESAAR MTGRTLRPVT PAEVPAALSD
160 170 180 190 200
RTAAVLLNHV DYRTGRLHDL PALTAAVHEA GAYAVWDLCH SAGALPVDLD
210 220 230 240 250
EHGVDLAIGC TYKYLNGGPG SPAYLYVRRD LQPRFDSPLP GWTSHAAPFA
260 270 280 290 300
MRPAYEAAAG APRGRVGTPD ILSMLALEAA LDVWYEGGDG GAAGAGATIA
310 320 330 340 350
AVRAKSLALT DFFLRCVAAY VPEGRVESLT PVAHAERGSQ VALRCDDAGD
360 370 380 390
VMKRLIHRGV IGDFRHPDVL RFGFTPLYVT FADVERAARV LAETLGEAG
Length:399
Mass (Da):42,415
Last modified:November 24, 2009 - v1
Checksum:iBF8D4A233A92809D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554889 Genomic DNA. Translation: CBG71283.1.

Genome annotation databases

EnsemblBacteriaiCBG71283; CBG71283; SCAB_42121.
KEGGiscb:SCAB_42121.

Similar proteinsi

Entry informationi

Entry nameiC9Z429_STRSW
AccessioniPrimary (citable) accession number: C9Z429
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: September 27, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported