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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Streptomyces scabiei (strain 87.22)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:SCAB_26561
OrganismiStreptomyces scabiei (strain 87.22)
Taxonomic identifieri680198 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001444 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987171 – 2162-phospho-L-lactate guanylyltransferaseAdd BLAST216

Interactioni

Protein-protein interaction databases

STRINGi680198.SCAB_26561.

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ME0. Bacteria.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OMAiAMLVDTI.
OrthoDBiPOG091H0B3J.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiIPR002835. Coenzyme_F420_CofC.
IPR025877. MobA-like_NTP_Trfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF12804. NTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

C9Z3U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWTLVVPVK PLARAKSRLS DTAADAVRPG LALAFAQDTV AAALAATAVR
60 70 80 90 100
GVVVVTDDPL AARELTALGA RAVPEDPGGG PGDGLNAALR HGAALVRDVR
110 120 130 140 150
PQSPVAALNA DLPALRPGEL TRVLGAAAAF PRAFLADAAG TGTTLLAAAP
160 170 180 190 200
GHGLSPAFGP GSRTRHRRSG AVELDLTAVD SVRQDVDTGD DLRAALGLGV
210
GPRTAAAAAR LLIPGQ
Length:216
Mass (Da):21,607
Last modified:November 24, 2009 - v1
Checksum:i5235A43D8E5DE2F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554889 Genomic DNA. Translation: CBG69760.1.
RefSeqiWP_013000446.1. NC_013929.1.

Genome annotation databases

EnsemblBacteriaiCBG69760; CBG69760; SCAB_26561.
GeneIDi24313109.
KEGGiscb:SCAB_26561.
PATRICi35320986. VBIStrSca144334_2602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554889 Genomic DNA. Translation: CBG69760.1.
RefSeqiWP_013000446.1. NC_013929.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi680198.SCAB_26561.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBG69760; CBG69760; SCAB_26561.
GeneIDi24313109.
KEGGiscb:SCAB_26561.
PATRICi35320986. VBIStrSca144334_2602.

Phylogenomic databases

eggNOGiENOG4105ME0. Bacteria.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OMAiAMLVDTI.
OrthoDBiPOG091H0B3J.

Enzyme and pathway databases

UniPathwayiUPA00071.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiIPR002835. Coenzyme_F420_CofC.
IPR025877. MobA-like_NTP_Trfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF12804. NTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOFC_STRSW
AccessioniPrimary (citable) accession number: C9Z3U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: November 24, 2009
Last modified: November 2, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.