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Protein

D-alanine--D-alanine ligase

Gene

ddlA

Organism
Streptomyces scabiei (strain 87.22)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi329Magnesium or manganese 1UniRule annotation1
Metal bindingi342Magnesium or manganese 1UniRule annotation1
Metal bindingi342Magnesium or manganese 2UniRule annotation1
Metal bindingi344Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlAImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:SCAB_26531Imported
OrganismiStreptomyces scabiei (strain 87.22)Imported
Taxonomic identifieri680198 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001444 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi680198.SCAB_26531.

Structurei

3D structure databases

ProteinModelPortaliC9Z3U1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 375ATP-graspInterPro annotationAdd BLAST211

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000011593.
KOiK01921.
OMAiYETKYTE.
OrthoDBiPOG091H06GK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C9Z3U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTENLPQSP EQPSRKPRVA VVFGGRSSEH GISVVTAGAV LRAIDRTKYD
60 70 80 90 100
VLPIGITREG RWFLTADEPE RMAITDRRTP SVEELAESRE GGVVLPVDPA
110 120 130 140 150
NREVVYSEPG SVPKALGEVD VVFPVLHGPY GEDGTLQGML ELSGVPYVGS
160 170 180 190 200
GVLASAVGQD KEYMKRVFTS FGLKVGPYVV IRPREWQLDE AAARKKIIDL
210 220 230 240 250
AGEHGWPLFV KPARAGSSIG ITKVDDLAGL DEAIAEAQRH DPKILVEAAL
260 270 280 290 300
RGREIECGVL EFEDGPRASV PAEIPPPETH AYYDFDAKYI DSTPGIVPAP
310 320 330 340 350
LTPEETAEVR RLAVDAFDAA SCEGLVRADF FLTEDGEFVI NEINTLPGFT
360 370 380
PISMYPAMWQ ASGIEYPELV DRLIQAALHR PTGLR
Length:385
Mass (Da):41,881
Last modified:November 24, 2009 - v1
Checksum:iB38C42765D882259
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554889 Genomic DNA. Translation: CBG69757.1.
RefSeqiWP_013000443.1. NC_013929.1.

Genome annotation databases

EnsemblBacteriaiCBG69757; CBG69757; SCAB_26531.
GeneIDi24305906.
KEGGiscb:SCAB_26531.

Similar proteinsi

Entry informationi

Entry nameiC9Z3U1_STRSW
AccessioniPrimary (citable) accession number: C9Z3U1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: September 27, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported