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C9Z3U1 (C9Z3U1_STRSW) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL CBG69757.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:SCAB_26531 EMBL CBG69757.1
OrganismStreptomyces scabies (strain 87.22) (Streptomyces scabiei) [Complete proteome] [HAMAP] EMBL CBG69757.1
Taxonomic identifier680198 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain165 – 375211ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding201 – 25656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3291Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3421Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3421Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3441Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C9Z3U1 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: B38C42765D882259

FASTA38541,881
        10         20         30         40         50         60 
MSTENLPQSP EQPSRKPRVA VVFGGRSSEH GISVVTAGAV LRAIDRTKYD VLPIGITREG 

        70         80         90        100        110        120 
RWFLTADEPE RMAITDRRTP SVEELAESRE GGVVLPVDPA NREVVYSEPG SVPKALGEVD 

       130        140        150        160        170        180 
VVFPVLHGPY GEDGTLQGML ELSGVPYVGS GVLASAVGQD KEYMKRVFTS FGLKVGPYVV 

       190        200        210        220        230        240 
IRPREWQLDE AAARKKIIDL AGEHGWPLFV KPARAGSSIG ITKVDDLAGL DEAIAEAQRH 

       250        260        270        280        290        300 
DPKILVEAAL RGREIECGVL EFEDGPRASV PAEIPPPETH AYYDFDAKYI DSTPGIVPAP 

       310        320        330        340        350        360 
LTPEETAEVR RLAVDAFDAA SCEGLVRADF FLTEDGEFVI NEINTLPGFT PISMYPAMWQ 

       370        380 
ASGIEYPELV DRLIQAALHR PTGLR 

« Hide

References

[1]"Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions."
Bignell D.R., Seipke R.F., Huguet-Tapia J.C., Chambers A.H., Parry R.J., Loria R.
Mol. Plant Microbe Interact. 23:161-175(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 87.22 EMBL CBG69757.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN554889 Genomic DNA. Translation: CBG69757.1.
RefSeqYP_003488316.1. NC_013929.1.

3D structure databases

ProteinModelPortalC9Z3U1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBG69757; CBG69757; SCAB_26531.
GeneID8839626.
KEGGscb:SCAB_26531.
PATRIC35320980. VBIStrSca144334_2599.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAIECGVLG.

Enzyme and pathway databases

BioCycSSCA680198:GJ76-2545-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC9Z3U1_STRSW
AccessionPrimary (citable) accession number: C9Z3U1
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)