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Protein

Ribonuclease 3

Gene

rnc

Organism
Streptomyces scabiei (strain 87.22)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60MagnesiumUniRule annotation1
Active sitei64UniRule annotation1
Metal bindingi133MagnesiumUniRule annotation1
Active sitei136UniRule annotation1
Metal bindingi136MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease, RNA-binding, rRNA-bindingUniRule annotationSAAS annotation
Biological processmRNA processingUniRule annotationSAAS annotation, rRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotationImported
Ordered Locus Names:SCAB_26391Imported
OrganismiStreptomyces scabiei (strain 87.22)Imported
Taxonomic identifieri680198 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001444 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi680198.SCAB_26391

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 147RNase IIIInterPro annotationAdd BLAST120
Domaini174 – 242DRBMInterPro annotationAdd BLAST69

Sequence similaritiesi

Belongs to the ribonuclease III family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246808
KOiK03685
OMAiLTHKSCK
OrthoDBiPOG091H00R1

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

C9Z3S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAKAETNA KKKAENTASS HTLLEGRLGY KLESALLVRA LTHRSYAYEN
60 70 80 90 100
GGLPTNERLE FLGDSVLGLV VTDTLYRTHP DLPEGQLAKL RAAVVNSRAL
110 120 130 140 150
AEVGRGLDLG SFIRLGRGEE GTGGRDKASI LADTLEAVIG AVYLDQGLDS
160 170 180 190 200
AAELVHRLFD PLIEKSSNLG AGLDWKTSLQ ELTATEGLGV PEYLVTETGP
210 220 230 240 250
DHEKTFTAAA RVGGVSYGTG TGRSKKEAEQ QAAESAWRAI RSAADERAKA
260 270
AAEAAALVPD DSAETPSDAA PA
Length:272
Mass (Da):28,631
Last modified:November 24, 2009 - v1
Checksum:i4E4D9BCFE61A4FA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554889 Genomic DNA Translation: CBG69743.1
RefSeqiWP_013000429.1, NC_013929.1

Genome annotation databases

EnsemblBacteriaiCBG69743; CBG69743; SCAB_26391
GeneIDi24312894
KEGGiscb:SCAB_26391

Similar proteinsi

Entry informationi

Entry nameiC9Z3S7_STRSW
AccessioniPrimary (citable) accession number: C9Z3S7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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