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Protein

Thymidine kinase

Gene

tdk

Organism
Streptomyces scabies (strain 87.22) (Streptomyces scabiei)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 248ATPUniRule annotation
Nucleotide bindingi94 – 974ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSCA680198:GJ76-2315-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:SCAB_24181Imported
OrganismiStreptomyces scabies (strain 87.22) (Streptomyces scabiei)Imported
Taxonomic identifieri680198 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
ProteomesiUP000001444 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi680198.SCAB_24181.

Structurei

3D structure databases

ProteinModelPortaliC9Z0I0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

C9Z0I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGAQLTMP ELVFFSGTMD CGKSTLALQI EHNRSARGLQ GMIFTRDDRA
60 70 80 90 100
GEGKLSSRLG LVTDAVEVED GQDLYAYLVD HLSQGRRADY VIADEAQFLA
110 120 130 140 150
PEQIDQLARV VDDLSLDVYA FGITTDFRSK LFPGSQRLVE LADRVEVLQV
160 170 180 190 200
EALCWCGARA THNARTIGGQ MVVEGAQVVV GDVNQPDDIG YEVLCRRHHR
210 220
RRMTAASAHA SALAPDVLPV ETV
Length:223
Mass (Da):24,428
Last modified:November 24, 2009 - v1
Checksum:i1BCE0D6D2FA23886
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554889 Genomic DNA. Translation: CBG69533.1.
RefSeqiWP_005481579.1. NC_013929.1.

Genome annotation databases

EnsemblBacteriaiCBG69533; CBG69533; SCAB_24181.
GeneIDi24314296.
KEGGiscb:SCAB_24181.
PATRICi35320498. VBIStrSca144334_2362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554889 Genomic DNA. Translation: CBG69533.1.
RefSeqiWP_005481579.1. NC_013929.1.

3D structure databases

ProteinModelPortaliC9Z0I0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi680198.SCAB_24181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBG69533; CBG69533; SCAB_24181.
GeneIDi24314296.
KEGGiscb:SCAB_24181.
PATRICi35320498. VBIStrSca144334_2362.

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.

Enzyme and pathway databases

BioCyciSSCA680198:GJ76-2315-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions."
    Bignell D.R., Seipke R.F., Huguet-Tapia J.C., Chambers A.H., Parry R.J., Loria R.
    Mol. Plant Microbe Interact. 23:161-175(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 87.22Imported.

Entry informationi

Entry nameiC9Z0I0_STRSW
AccessioniPrimary (citable) accession number: C9Z0I0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: July 22, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.