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C9Z0I0

- C9Z0I0_STRSW

UniProt

C9Z0I0 - C9Z0I0_STRSW

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Protein
Thymidine kinase
Gene
tdk, SCAB_24181
Organism
Streptomyces scabies (strain 87.22) (Streptomyces scabiei)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton acceptor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 248ATP By similarityUniRule annotation
Nucleotide bindingi94 – 974ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSCA680198:GJ76-2315-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:SCAB_24181Imported
OrganismiStreptomyces scabies (strain 87.22) (Streptomyces scabiei)Imported
Taxonomic identifieri680198 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000001444: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC9Z0I0.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

C9Z0I0-1 [UniParc]FASTAAdd to Basket

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MPKGAQLTMP ELVFFSGTMD CGKSTLALQI EHNRSARGLQ GMIFTRDDRA    50
GEGKLSSRLG LVTDAVEVED GQDLYAYLVD HLSQGRRADY VIADEAQFLA 100
PEQIDQLARV VDDLSLDVYA FGITTDFRSK LFPGSQRLVE LADRVEVLQV 150
EALCWCGARA THNARTIGGQ MVVEGAQVVV GDVNQPDDIG YEVLCRRHHR 200
RRMTAASAHA SALAPDVLPV ETV 223
Length:223
Mass (Da):24,428
Last modified:November 24, 2009 - v1
Checksum:i1BCE0D6D2FA23886
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN554889 Genomic DNA. Translation: CBG69533.1.
RefSeqiYP_003488092.1. NC_013929.1.

Genome annotation databases

EnsemblBacteriaiCBG69533; CBG69533; SCAB_24181.
GeneIDi8839429.
KEGGiscb:SCAB_24181.
PATRICi35320498. VBIStrSca144334_2362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN554889 Genomic DNA. Translation: CBG69533.1 .
RefSeqi YP_003488092.1. NC_013929.1.

3D structure databases

ProteinModelPortali C9Z0I0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBG69533 ; CBG69533 ; SCAB_24181 .
GeneIDi 8839429.
KEGGi scb:SCAB_24181.
PATRICi 35320498. VBIStrSca144334_2362.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.

Enzyme and pathway databases

BioCyci SSCA680198:GJ76-2315-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions."
    Bignell D.R., Seipke R.F., Huguet-Tapia J.C., Chambers A.H., Parry R.J., Loria R.
    Mol. Plant Microbe Interact. 23:161-175(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 87.22Imported.

Entry informationi

Entry nameiC9Z0I0_STRSW
AccessioniPrimary (citable) accession number: C9Z0I0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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