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C9YVX5 (C9YVX5_STRSW) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase 2 HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase 2 HAMAP MF_00315
Gene names
Name:dxs2 HAMAP MF_00315
Ordered Locus Names:SCAB_20991
OrganismStreptomyces scabies (strain 87.22) (Streptomyces scabiei) [Complete proteome] [HAMAP]
Taxonomic identifier680198 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length639 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS005477

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS005477

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS005477

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS005477

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS005477

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
C9YVX5 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 17F659D0AC936B77

FASTA63968,626
        10         20         30         40         50         60 
MPLLTRIRGP RDLDRLSLEE LDQLAEEIRT FLVEAVSKTG GHLGPNLGVV ELTIAMHRVF 

        70         80         90        100        110        120 
DSPRDKVLWD TGHQSYVHKL LTGRQDFSRL KMKGGLSGYP SQAESEHDVI ENSHASTVLG 

       130        140        150        160        170        180 
WADGLAKANQ VLKRDDHVVA VIGDGALTGG MAWEALNNIA DAKDRPLVIV VNDNERSYAP 

       190        200        210        220        230        240 
TIGGLANHLA TLRTTDGYER FLARGKDLLE RTPVVGRPLY ETLHGAKKGL KDFIAPQGMF 

       250        260        270        280        290        300 
EDLGLKYVGP IDGHDIEALE SALARAKRFG GPVIVHCLTE KGRGYQPALQ DEADRFHAVG 

       310        320        330        340        350        360 
KIHPDTGLPI ASSGADWTSV FGEEMVKLGK EREDIVAITA AMLQPVGLDK FAKAFPERVY 

       370        380        390        400        410        420 
DVGIAEQHAA VSAAGLATGG LHPVFAVYAT FLNRAFDQVL MDVALHRCGV TFVLDRAGVT 

       430        440        450        460        470        480 
GTDGASHNGM WDMSILQVVP GLRLAAPRDA DQVRAQLREA VEVTDAPTVV RFSKGAVGPA 

       490        500        510        520        530        540 
VPALRRVGGM DVLREPGTDT PDVLLVSVGA LAPMCLEIAD LLDKQGITTT VVDPRWVKPV 

       550        560        570        580        590        600 
DEHMAPLADK HRVVVTVEDN SRVGGVGSAV AQALRDAGVD IPLRDFGIPP RFLDHASRAE 

       610        620        630 
VLAEIGLTAP DIARQVTGLV SKIDGRFGDT AAPVESARD

« Hide

References

[1]"Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions."
Bignell D.R., Seipke R.F., Huguet-Tapia J.C., Chambers A.H., Parry R.J., Loria R.
Mol. Plant Microbe Interact. 23:161-175(2010) [PubMed: 20064060] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 87.22 EMBL CBG69214.1.
[2]Bentley S.D.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 87.22 EMBL CBG69214.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN554889 Genomic DNA. Translation: CBG69214.1.
RefSeqYP_003487777.1. NC_013929.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8839094.
GenomeReviewsGene locus SCAB_20991 in contig FN554889_GR.
KEGGscb:SCAB_20991.
PATRIC35319886. VBIStrSca144334_2057.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMALHPTGLA.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC9YVX5_STRSW
AccessionPrimary (citable) accession number: C9YVX5
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: December 14, 2011
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info